Abstract
Fever is a highly complex response in mammalian host defense systems that results in a temporary rise of basal temperature and seems to be mediated by action of endogenous pyrogens including interleukin (IL)-1± and -1beta, IL-6, tumor necrosis factor-± (TNF-±), IL-8, C-C-ligands/macrophage inflammatory protein-1± and beta (CCL3 /MIP-1± and CCL4/MIP-1beta) and pre-formed pyrogenic factor (…