Patricia Santos Lopes
CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy and Biochemistry - Faculty Oswaldo Cruz (1992), Master Degree, University of São Paulo (1999) and a PhD Degree, University of São Paulo (2003). Currently I am an assistant professor at the Federal University of São Paulo, Pharmacy Course, Campus Diadema and I am an effetive member of the Pos-graduation Course in Pharmaceutical Sciences UNIFESP. I have experience in Pharmacy, with emphasis on Analysis and Control of Medicines, acting on the following topics: papain - different pharmaceutical forms, maintenance of stability and enzyme activity; microbiological analysis of drugs and synthetic or natural active substances, mainly extracts with potential antimicrobial activity; Cell culture of human keratinocytes; evaluation of cytotoxicity, phototoxicity, genotoxicity of active substances, drugs and nanoparticles; evaluation of cytotoxicity using phototoxicity and cosmetic dermal-epidermal or epidermal equivalent; development of scaffolds for the production of dermal-epidermal equivalent; development and evaluation of wound healings by physical, chemical and biological techniques. (Source: Lattes Curriculum)
- In vitro evaluation of lipogenics and anti-adipogenics substances using three-dimensional model of adipocytes, AP.R
Abstract
The hyperplasia and hypertrophy of the adipocytes, generates a lot of dissatisfaction, especially in women, so research that reorganize the adipose tissue are frequent and necessary. Currently there is no in vitro model to test formulations for the treatment of cellulite and adipocyte dysfunctions, described in literature, even with the implementation of international and national laws ...
- Papain oral products for intestinal treatment evaluation using triple co-culture of Caco-2, HT29-MTX and Raji cells as an in vitro model, AP.R
Abstract
Currently the production of medicines containing enzymes have been promising due to the magnitude of their therapeutic potential. Papain is a proteolytic enzyme isolated from the latex of leaves and green fruit of papaya (Carica papaya Linnaeus) widely used as a debridant agent in the processes of healing and treatment of wounds mainly due to its ability to promote tissue growth in addi...
- 9th world Congress on alternatives and animal use in the Life Sciences, AR.EXT
- 8th world congress on alternatives and animal use in the Life Sciences, AR.EXT
(Only some records are available in English at this moment)
- Papain permeability evaluation in oral pharmaceuticals formulations for treatment of intestinal diseases triple co-culture of Caco-2, HT29-MTX and Raji cells as in vitro model, BP.MS
Abstract
Currently the production of medicines containing enzymes have been promising due to the magnitude of their therapeutic potential. Papain is a proteolytic enzyme isolated from the latex of leaves and green fruit of papaya adult (Carica papaya Linné) widely used as a debridement agent in the processes of healing and treatment of wounds mainly due to its ability to promote tissue growth in...
- Isolation and use of mesenchymal cells in chitosan and epichlorohydrin nano-structured scaffolds to be used as dermo-epidermic equivalents or as biodressing, BP.IC
Abstract
The development of scaffolds made of biocompatible, biodegradable and bioactive materials, has a great potential in bioengineering. Chitosan is a biomaterial with different biological properties that allows the development of a scaffold with satisfactory qualities. With the introduction of mesenchymal cells from adipose tissue and deciduous tooth, in these scaffolds, you can observe the...
- Biological and physic-chemical evaluations of scaffolds of chitosan and sodium tripolyphosphate: possible use with mesenchymal cells, BP.IC
Abstract
Tissue regeneration is a process that involves the proliferation of cells within a pre-determined area. In order to create a three-dimensional structure that play such a role, were developed in a previous project (started from the program young talent for science, CAPES) spongy membranes, called scaffold, obtained from Chitosan and sodium tripolyphosphate. Chitosan is a polysaccharide o...
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 4 / 3 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORAZZA, FULVIO G.; ERNESTO, V, JULIA; NAMBU, FELIPE A. N.; DE CARVALHO, LUMA R.; LEITE-SILVA, VANIA R.; VARCA, GUSTAVO H. C.; CALIXTO, LEANDRO A.; VIEIRA, DANIEL P.; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S.. Papain-cyclodextrin complexes as an intestinal permeation enhancer: Permeability and in vitro safety evaluation. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 55, FEB 2020. Web of Science Citations: 0. (15/19212-3, 10/10935-9, 16/22916-5, 15/19213-0)