Gilberto de Castro Junior in research grants and scholarships supported by FAPESP.
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Chronic inflammation modulates the tumor microenvironment interaction with the immune system and plays a critical role in tumor progression and immune system evasion. NLRP3 inflammasome complex activation is central to the inflammatory response and drives the interleukin-1beta pathway with downstream activation of IL-1beta, IL-6 and IL-18. An important proof of concept of the effects of i…
Head and neck squamous cell carcinoma (HNSCC) is a major cause of morbidity and mortality in cancer patients worldwide. Most patients with HNSCC are diagnosed with locally advanced disease, and treated with cisplatin-based chemoradiation, but long-term disease control is still a challenge. The incorporation of epigenetic regulation into standard treatment could improve results of definit…
Salivary glands Carcinomas are rare malignant tumors from major and minor salivary glands, corresponding to 0.28% of all globally estimated cancers in 2020. They are classified into 22 histologically different subtypes (WHO, 2017); this is due to salivary glands' complex histology, composed of diverse cell types. Among the most common subtypes are mucoepidermoid carcinoma, adenoid cystic …
The prognosis of patients with oral squamous cell Carcinoma (OSCC) is dependent on several factors. The TNM classification (AJCC) in its eighth edition improved its prognostic accuracy by incorporating new variables. More recently, the detrimental impact of inflammation and the presence of sarcopenia on the clinical outcome of OSCC patients treated with curative intent have been well reco…
Thymomas are tumors of the epithelial cells of the thymus and are the most common type of tumor of the anterior mediastinum. It is a rare tumor (0.13 per 100,000 inhabitants)(10) that is frequently associated with autoimmune disorders, such as myasthenia gravis. Several classifications have been described, with different accuracy in terms of impact on clinical practice. Currently, the cla…
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Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer and the leading cause of cancer-related deaths worldwide. Patients are frequently diagnosed in advanced stages and about half of all NSCLC patients present cancer cachexia, a syndrome characterized by skeletal muscle wasting, lower response to anticancer treatments and poor prognosis. Preliminary Data: We set to det…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 10 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 13 | All research grants and scholarships |
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