Carolina Demarchi Munhoz
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Assistant Professor at the Department of Pharmacology, ICB, USP. Holds a Ph.D. in Science (Pharmacology) from the University of São Paulo (2005) with Ph.D. Internships at Complutense University of Madrid, Spain (2002) and Stanford University, Palo Alto, CA-USA. Graduated in Pharmacy-Biochemistry from the São Paulo State University (UNESP - 1999) and was a post-doc fellow at the Department of Pharmacology ? ICB/USP (2006) and at Stanford University (2006-2009). My scientific focus is in Pharmacology, with the emphasis in Neurosciences, Neuroendocrinology, Neuroinflammation, and Biochemical and Molecular Pharmacology. (Source: Lattes Curriculum)
- Stress-induced anxiety-like behaviors: glucocorticoid signaling in neuronal hyperexcitability and mitochondrial dysfunction within the basolateral amygdala complex, AP.R
Abstract
Anxiety-related disorders are common among psychiatric patients and are widely present in studies focusing on stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating stress-related disorder. The amygdala is a fundamental brain structure essential for b...
- Neuroimmunology in experimental models of Autoimmune Encephalomyelitis and Congenital Zika Syndrome: physiopathogenesis, susceptibility, cellular therapy, vaccination, AP.TEM
Abstract
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer, Multiple Sclerosis and Parkinson Disease. On the other side, the spread of ...
- The relationship between glucocorticoid receptor activation and the neuronal hyperexcitability in the basolateral amygdala in the restraint stress-induced long-lasting anxiety and their implications in the impaired contextual fear extinction, AP.R
Abstract
Anxiety-related disorders are common among psychiatric patients and are widely present in studies devoted to stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating anxiety-related disorder. The amygdala is a key brain structure essential for behaviora...
- Comparison of the therapeutical effects of dexamethasone (a synthetic glucocorticoid analogue), and G1 (a G-coupled estrogen receptor, GPER agonist) on the EAE-induced neuroinflammation, AP.R
Abstract
Multiple sclerosis (MS) is a debilitating neurological and autoimmune disease, characterized by inflammation, demielinization, and neurodegeneration. Neuroinflammation is an important finding in MS pathogenesis, contributing for the progression of the disease. Glial cells (microglia and astrocytes) also have a key role in the progression of MS. Systemic corticosteroids, such as dexameth...
- The role of microglia in the mitochondrial damage and mood disorders promoted by chronic restraint stress in C57BL/6 mice, BP.PD
Abstract
According to recent studies, mood disorders such as depression, anxiety, and post-traumatic stress disorder comprise a health problem in the modern world, affecting 15% of the population. In addition, less than half of the patients treated with antidepressants show an improvement in symptoms. Furthermore, patients diagnosed with depression have high levels of circulating pro-inflammator...
- The role of glucocorticoids and the vagus nerve afferences on the neuronal activity and plasticity of central circuits and their implications for stress-induced anxiety in rats, BP.PD
Abstract
Stress-related disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD), are recurrent causes of occupational absence in Brazil. Both acute restraint stress and transient elevation of glucocorticoid (GC) levels induce anxiety behaviors as well as dendritic branching within the basolateral complex of the amygdala (BLA) of rodents. The BLA is one fundamental struc...
- The persistence of acute restraint stress-induced anxiety-like behavior in rats: the glucocorticoids as modulators of the dendritic plasticity and the neuronal activity in the basolateral amygdala complex, BP.IC
Abstract
Anxiety disorders generate a range of behavioral responses to danger triggered by innocuous and unpredictable stimuli. Both acute stress and elevated concentrations of glucocorticoid hormones (GCs) promote persistent anxiety-related behavior as well as increased density of dendritic spines in the basolateral amygdala complex (BLA) in rats. BLA is a key structure for fear behavior and an...
(Only some records are available in English at this moment)
- The importance of glucocorticoid receptors in late anxiety and dendritic remodeling in BLA induced by acute stress in rats, BP.IC
Abstract
Anxiety-related disorders are common among the psychiatric patients and are widely present in studies devoted to stress, which use different approaches to investigate the neurobiological mechanisms underlying the persistence of anxiety symptoms caused by a stressful event. It is well known that acute restraint stress or increased serum levels of glucocorticoid (GC) stress hormones induc...
- Effects of environmental enrichment in long-lasting anxiety symptoms triggered by acute stress: implications in the emotional memory acquisition, BP.DR
Abstract
The consequences of stressful events on human health, especially related to psychiatric disorders, has gained notoriety in recent years due to the increasing number of comorbidities associated to stress registered in large cities. Emotional disorders related to anxiety symptoms are common among the psychiatric patients and have increasing in importance in scientific papers devoted to st...
- Protection conferred by environmental enrichment on stress-induced anxiety: the importance of GR, ERK, and CREB pathways in the rat basolateral amygdala, BP.MS
Abstract
Environmental enrichment (EE) is an experimental model that enhances the opportunity of animals to interact with sensory, motor, and social stimuli compared to the standard conditions. Among the benefits of EE are the improvements in learning and memory, as well as reduction in stress-induced behaviors, including anxiety. Overall, the most conclusive findings on the latter issue show a ...
(Only some records are available in English at this moment)
- Stressing the lungs: neuronal plasticity in allergic airway inflammation, BE.EP.DD
Abstract
Asthma, a chronic inflammatory disease affecting the airways, represents a major cost for public healthcare systems worldwide. Diverse lines of evidence, including data from our group, shows that the airway neuronal network in asthma is changed and contributes to airway hyperresponsiveness and inflammation This plasticity might, therefore, represent a potential druggable target.For a lo...
- Restraint stress-induced long-lasting anxiety and contextual fear extinction impairment in rats: role of glucocorticoid and ghrelin receptors on BLA neuronal excitability, BE.EP.DR
Abstract
Anxiety-related disorders are common among psychiatric patients and are widely present in studies devoted to stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating anxiety-related disorder. Several approaches have been focusing on environmental influe...
| 2 / 2 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 12 / 5 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 24 / 16 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 305 |
| Cit./Article | 25.4 |
| Data from Web of Science | |
MUNHOZ, C. D.; GARCIA-BUENO, B.; MADRIGAL, J. L. M.; LEPSCH, L. B.; SCAVONE, C.; LEZA, J. C.. Stress-induced neuroinflammation: mechanisms and new pharmacological targets. Brazilian Journal of Medical and Biological Research, v. 41, n. 12, p. 1037-1046, DEC 2008. Web of Science Citations: 120.
KAWAMOTO, E. M.; LIMA, L. S.; MUNHOZ, C. D.; YSHII, L. M.; KINOSHITA, P. F.; AMARAL, F. G.; PESTANA, R. R. F.; ORELLANA, A. M. M.; CIPOLLA-NETO, J.; BRITTO, L. R. G.; et al. Influence of N-methyl-D-aspartate receptors on ouabain activation of nuclear factor-kappa B in the rat hippocampus. Journal of Neuroscience Research, v. 90, n. 1, p. 213-228, JAN 2012. Web of Science Citations: 25.
KAWAMOTO, ELISA MITIKO; MUNHOZ, CAROLINA DEMARCHI; LEPSCH, LUCILIA BROCHADO; LIMA, LARISSA DE SA; GLEZER, ISAIAS; MARKUS, REGINA PEKELMANN; MARTINS DE SILVA, CLAUDIA LUCIA; CAMARINI, ROSANA; MARCOURAKIS, TANIA; SCAVONE, CRISTOFORO. Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity. NEUROBIOLOGY OF AGING, v. 29, n. 11, p. 1712-1720, NOV 2008. Web of Science Citations: 7.
DEGASPARI, SABRINA; TZANNO-MARTINS, CARMEN BRANCO; FUJIHARA, CLARICE KAZUE; ZATZ, ROBERTO; BRANCO-MARTINS, JOAO PAULO; VIEL, TANIA ARAUJO; BUCK, HUDSON DE SOUZA; MARQUES ORELLANA, ANA MARIA; BOEHMER, ANA ELISA; LIMA, LARISSA DE SA; et al. Altered KLOTHO and NF-kappa B-TNF-alpha Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats. PLoS One, v. 10, n. 5, MAY 11 2015. Web of Science Citations: 22.
NOVAES, LEONARDO S.; DOS SANTOS, NILTON BARRETO; BATALHOTE, RAFAELA F. P.; MALTA, MARILIA BRINATI; CAMARINI, ROSANA; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala. Neuropharmacology, v. 113, n. A, p. 457-466, FEB 2017. Web of Science Citations: 20. (10/13843-8, 12/24727-4, 16/03572-3)
DUQUE, ERICA DE ALMEIDA; MUNHOZ, CAROLINA DEMARCHI. The Pro-inflammatory Effects of Glucocorticoids in the Brain. FRONTIERS IN ENDOCRINOLOGY, v. 7, JUN 28 2016. Web of Science Citations: 17. (12/24727-4, 10/13932-0)
MUNHOZ, CAROLINA DEMARCHI; SORRELLS, SHAWN F.; CASO, JAVIER R.; SCAVONE, CRISTOFORO; SAPOLSKY, ROBERT M.. Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner. JOURNAL OF NEUROSCIENCE, v. 30, n. 41, p. 13690-13698, OCT 13 2010. Web of Science Citations: 81.
GLEZER‚ I.; MUNHOZ‚ C.D.; KAWAMOTO‚ E.M.; MARCOURAKIS‚ T.; AVELLAR‚ M.C.W.; SCAVONE‚ C.. MK-801 and 7-Ni attenuate the activation of brain NF-[kappa] B induced by LPS. Neuropharmacology, v. 45, n. 8, p. 1120-1129, 2003. (02/03506-8)
NOVAES, LEONARDO SANTANA; DOS SANTOS, NILTON BARRETO; PERFETTO, JULIANO GENARO; GOOSENS, KI ANN; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density. PSYCHONEUROENDOCRINOLOGY, v. 98, p. 6-10, DEC 2018. Web of Science Citations: 2. (12/24727-4, 16/03572-3, 12/24002-0)
NOVAES, LEONARDO SANTANA; DOS SANTOS, NILTON BARRETO; DRAGUNAS, GUILHERME; PERFETTO, JULIANO GENARO; CARLOS LEZA, JUAN; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats. Neuroscience, v. 393, p. 273-283, NOV 21 2018. Web of Science Citations: 3. (10/13843-8, 12/24727-4, 16/03572-3, 12/24002-0)
RUSSELL, ASHLEY L.; TASKER, JEFFREY G.; LUCION, ALDO B.; FIEDLER, JENNY; MUNHOZ, CAROLINA D.; WU, TAO-YIAO JOHN; DEAK, TERRENCE. Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease. Journal of Neuroendocrinology, v. 30, n. 10, SI, OCT 2018. Web of Science Citations: 6. (12/24727-4, 16/03572-3)
DOS SANTOS, NILTON; NOVAES, LEONARDO S.; DRAGUNAS, GUILHERME; RODRIGUES, JENNIFER R.; BRANDAO, WESLEY; CAMARINI, ROSANA; SCHATZMANN PERON, JEAN PIERRE; DEMARCHI MUNHOZ, CAROLINA. High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice. SCIENTIFIC REPORTS, v. 9, APR 30 2019. Web of Science Citations: 1. (12/24727-4, 12/24002-0, 16/03572-3, 11/18703-2)
VASCONCELOS, ANDREA RODRIGUES; DOS SANTOS, NILTON BARRETO; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders. FRONTIERS IN PHARMACOLOGY, v. 10, FEB 4 2019. Web of Science Citations: 1. (12/24727-4, 16/07427-8)
(References retrieved automatically from State of São Paulo Research Institutions)
DUQUE, Erica de Almeida. Efeito dos glicocorticóides na resposta inflamatória induzida por LPS em cultura de células primárias fronto-corticais de ratos neonatos.. 2013. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/13932-0)
LOPES, Dielly Catrina Favacho. Participação do receptor GPER-1 na neuroproteção mediada por estrógeno em modelo de isquemia por privação de glicose/oxigênio em células corticais cerebrais.. 2014. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/51409-8)
BATALHOTE, Rafaela Florindo Pestana Ferrão. Estudos da transmissão neuromuscular e do músculo esquelético em um modelo experimental de Esclerose Múltipla em camundongos.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/50119-9)
NOVAES, Leonardo Santana. Proteção conferida pelo enriquecimento ambiental na ansiedade induzida por estresse: a importância da sinalização via GR, ERK e CREB no complexo amigdalóide basolateral de ratos.. 2013. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/13843-8)