CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor at the Department of Pharmacology, ICB, USP. Holds a Ph.D. in Science (Pharmacology) from the University of São Paulo (2005) with Ph.D. Internships at Complutense University of Madrid, Spain (2002) and Stanford University, Palo Alto, CA-USA. Graduated in Pharmacy-Biochemistry from the São Paulo State University (UNESP - 1999) and was a post-doc fellow at the Department of Pharmacology ICB/USP (2006) and at Stanford University (2006-2009). My scientific focus is in Pharmacology, with the emphasis in Neurosciences, Neuroendocrinology, Neuroinflammation, and Biochemical and Molecular Pharmacology. (Source: Lattes Curriculum)
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Leaky gut syndrome, characterized by increased intestinal permeability, has been linked to a myriad of health issues, including autoimmune diseases, metabolic disorders, and neurological conditions. Emerging evidence suggests that stress-induced dysbiosis, alterations in the composition of the gut microbiota, plays a crucial role in exacerbating gut permeability. However, the precise mech…
With the demonstration of the protective and antioxidant effects of estrogen (E2), the female sex hormone, in several pathologies, including the central nervous system (CNS), it has become mandatory to better comprehend its actions in the body, including in males. Clinical and experimental studies show such actions of E2 in stroke, the second leading cause of death and disability worldwid…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies focusing on stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating stress-related disorder. The amygdala is a fundamental brain structure essential for beh…
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer's, Multiple Sclerosis and Parkinson's Disease. On the other side, the spread o…
(Only some records are available in English at this moment)
Glucocorticoids (GCs), like cortisol in humans, are steroid hormones essential for endocrine regulation and adaptation to stress. They interact with specific receptors, such as glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs), affecting processes ranging from neuronal differentiation to mood control and cognition. Prenatal exposure to synthetic glucocorticoids, such as…
Throughout life, it is inevitable to experience stressful situations; in some cases, brain structures such as the hypothalamus, amygdala, and hippocampus (HP) are affected, which can trigger or worsen anxiety disorders and impair memory processing and learning. Glucocorticoid hormones (GCs), released by activation of the hypothalamic-pituitary-adrenal axis (HPA axis), are the main mediato…
Prolonged periods of stress may cause or potentiate pathologies. Stress activates the hypothalamic-pituitary-adrenal axis (HPA axis), ultimately releasing glucocorticoid hormones (GCs) which activate mineralocorticoid (MR) and glucocorticoid (GR) receptors. These receptors will mediate rapid and delayed responses to stress and the formation and maintenance of aversive memories. MR and GR …
(Only some records are available in English at this moment)
Stress is critical in developing neuropsychiatric disorders such as post-traumatic stress disorder (PTSD). This relationship is mediated by changes in brain structures, such as the basolateral amygdala complex (BLA), whose activity is increased in the face of stressful experiences and is associated with the manifestation of fear and anxiety, in addition to mediating the extinction of aver…
(Only some records are available in English at this moment)
Stress constitutes a significant risk factor for psychiatric disorder development, such as post-traumatic stress disorder (PTSD). Some of PTSD's characteristic symptoms are impaired fear extinction and avoidance. The neurobiological mechanisms governing the fear extinction deficit and avoidance are extensively studied in rodent models through Pavlovian and instrumental conditioning. The m…
Neuroinflammation is a crucial factor in the development of neurologic diseases such as Alzheimer's disease (AD). Microglia play an essential role in the neuroinflammatory process since they can produce pro-inflammatory cytokines and are also responsible for amyloid beta clearance in AD patients. Mitochondrial dysfunction can trigger the release of mitochondrial damage-associated molecula…
The bidirectional communication between the gastrointestinal tract (GI) and the brain has gained attention as a therapeutic target for psychiatric disorders, such as depression, anxiety, and stress-related disorders. The vagus nerve is a critical component of the autonomic nervous system implicated in the gut-to-brain communication. Subcutaneously vagal stimulation has been increasingly u…
The exposure to environmental factors during the perinatal period of development is associated with long-term changes in the organism. Exposure to stress and glucocorticoids (GCs) during this period can lead to several pathologies and systems malfunction. To accelerate lung maturation and reduce neonatal respiratory distress syndrome (RDS), synthetic GC receptor (GR) agonists (sGCs), as d…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 6 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 25 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 43 / 35 | All research grants and scholarships |
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