CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Associate Professor at the Department of Pharmacology, ICB, USP. Holds a Ph.D. in Science (Pharmacology) from the University of São Paulo (2005) with Ph.D. Internships at Complutense University of Madrid, Spain (2002) and Stanford University, Palo Alto, CA-USA. Graduated in Pharmacy-Biochemistry from the São Paulo State University (UNESP - 1999) and was a post-doc fellow at the Department of Pharmacology ICB/USP (2006) and at Stanford University (2006-2009). My scientific focus is in Pharmacology, with the emphasis in Neurosciences, Neuroendocrinology, Neuroinflammation, and Biochemical and Molecular Pharmacology. (Source: Lattes Curriculum)
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With the demonstration of the protective and antioxidant effects of estrogen (E2), the female sex hormone, in several pathologies, including the central nervous system (CNS), it has become mandatory to better comprehend its actions in the body, including in males. Clinical and experimental studies show such actions of E2 in stroke, the second leading cause of death and disability worldwid…
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer, Multiple Sclerosis and Parkinson Disease. On the other side, the spread of pa…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies focusing on stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating stress-related disorder. The amygdala is a fundamental brain structure essential for beh…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies devoted to stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating anxiety-related disorder. The amygdala is a key brain structure essential for behavioral …
Multiple sclerosis (MS) is a debilitating neurological and autoimmune disease, characterized by inflammation, demielinization, and neurodegeneration. Neuroinflammation is an important finding in MS pathogenesis, contributing for the progression of the disease. Glial cells (microglia and astrocytes) also have a key role in the progression of MS. Systemic corticosteroids, such as dexamethas…
Given the increase in the occurence of stressful factors on everyday life, mainly on large cities, the incidence of depression and anxiety disorders, such as generalized anxiety and Post Traumatic Stress Disorder (PTSD), also increases and has raised the attention of the World Health Organization (WHO). Therefore, the demand for studies concerning the neurobiological mechanisms involved o…
Stress-related disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD), are recurrent causes of occupational absence in Brazil. Both acute restraint stress and transient elevation of glucocorticoid (GC) levels induce anxiety behaviors as well as dendritic branching within the basolateral complex of the amygdala (BLA) of rodents. The BLA is one fundamental structu…
According to recent studies, mood disorders such as depression, anxiety, and post-traumatic stress disorder comprise a health problem in the modern world, affecting 15% of the population. In addition, less than half of the patients treated with antidepressants show an improvement in symptoms. Furthermore, patients diagnosed with depression have high levels of circulating pro-inflammatory …
Anxiety disorders generate a range of behavioral responses to danger triggered by innocuous and unpredictable stimuli. Both acute stress and elevated concentrations of glucocorticoid hormones (GCs) promote persistent anxiety-related behavior as well as increased density of dendritic spines in the basolateral amygdala complex (BLA) in rats. BLA is a key structure for fear behavior and anxi…
Much has been known in recent decades about the effects of estrogen on the body, in addition to its classic effects on reproduction. Its role on the central nervous system (CNS) proved to be extremely important, especially in pathological conditions where neuroprotective effects have been demonstrated. Intracellularly, estrogen interacts not only with its classical nuclear receptors (ERa …
(Only some records are available in English at this moment)
The exposure to environmental factors during the perinatal period of development is associated with long-term changes in the organism. Exposure to stress and glucocorticoids (GCs) during this period can lead to several pathologies and systems malfunction. To accelerate lung maturation and reduce neonatal respiratory distress syndrome (RDS), synthetic GC receptor (GR) agonists (sGCs), as d…
Asthma, a chronic inflammatory disease affecting the airways, represents a major cost for public healthcare systems worldwide. Diverse lines of evidence, including data from our group, shows that the airway neuronal network in asthma is changed and contributes to airway hyperresponsiveness and inflammation This plasticity might, therefore, represent a potential druggable target.For a long…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies devoted to stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating anxiety-related disorder. Several approaches have been focusing on environmental influenc…
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 16 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 27 / 19 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 138 |
| Cit./Article | 10.6 |
| Data from Web of Science | |
NOVAES, LEONARDO S.; DOS SANTOS, NILTON BARRETO; BATALHOTE, RAFAELA F. P.; MALTA, MARILIA BRINATI; CAMARINI, ROSANA; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala. Neuropharmacology, v. 113, n. A, p. 457-466, FEB 2017. Web of Science Citations: 22. (12/24727-4, 10/13843-8, 16/03572-3)
VASCONCELOS, ANDREA RODRIGUES; DOS SANTOS, NILTON BARRETO; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders. FRONTIERS IN PHARMACOLOGY, v. 10, FEB 4 2019. Web of Science Citations: 4. (12/24727-4, 16/07427-8)
DUQUE, ERICA DE ALMEIDA; MUNHOZ, CAROLINA DEMARCHI. The Pro-inflammatory Effects of Glucocorticoids in the Brain. FRONTIERS IN ENDOCRINOLOGY, v. 7, JUN 28 2016. Web of Science Citations: 17. (10/13932-0, 12/24727-4)
MALTA, MARILIA B.; MARTINS, JOELCIMAR; NOVAES, LEONARDO S.; DOS SANTOS, NILTON B.; SITA, LUCIANE; CAMARINI, ROSANA; SCAVONE, CRISTOFORO; BITTENCOURT, JACKSON; MUNHOZ, CAROLINA D.. Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation. Molecular Neurobiology, v. 58, n. 10, JUL 2021. Web of Science Citations: 1. (16/02224-1, 12/24727-4, 10/52068-0, 10/13843-8, 12/24002-0, 16/03572-3)
NOVAES, LEONARDO SANTANA; BUENO-DE-CAMARGO, LETICIA MORAIS; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation. TRANSLATIONAL PSYCHIATRY, v. 11, n. 1, JAN 5 2021. Web of Science Citations: 0. (18/19599-3, 18/15982-7, 12/24002-0, 19/00908-9, 16/03572-3)
DOS SANTOS, NILTON; NOVAES, LEONARDO S.; DRAGUNAS, GUILHERME; RODRIGUES, JENNIFER R.; BRANDAO, WESLEY; CAMARINI, ROSANA; SCHATZMANN PERON, JEAN PIERRE; DEMARCHI MUNHOZ, CAROLINA. High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice. SCIENTIFIC REPORTS, v. 9, APR 30 2019. Web of Science Citations: 1. (12/24727-4, 12/24002-0, 11/18703-2, 16/03572-3)
GLEZER‚ I.; MUNHOZ‚ C.D.; KAWAMOTO‚ E.M.; MARCOURAKIS‚ T.; AVELLAR‚ M.C.W.; SCAVONE‚ C.. MK-801 and 7-Ni attenuate the activation of brain NF-[kappa] B induced by LPS. Neuropharmacology, v. 45, n. 8, p. 1120-1129, 2003. (02/03506-8)
MUNHOZ, CAROLINA DEMARCHI; SORRELLS, SHAWN F.; CASO, JAVIER R.; SCAVONE, CRISTOFORO; SAPOLSKY, ROBERT M.. Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner. JOURNAL OF NEUROSCIENCE, v. 30, n. 41, p. 13690-13698, OCT 13 2010. Web of Science Citations: 77.
RUSSELL, ASHLEY L.; TASKER, JEFFREY G.; LUCION, ALDO B.; FIEDLER, JENNY; MUNHOZ, CAROLINA D.; WU, TAO-YIAO JOHN; DEAK, TERRENCE. Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease. Journal of Neuroendocrinology, v. 30, n. 10, SI, OCT 2018. Web of Science Citations: 7. (12/24727-4, 16/03572-3)
NOVAES, LEONARDO SANTANA; DOS SANTOS, NILTON BARRETO; PERFETTO, JULIANO GENARO; GOOSENS, KI ANN; MUNHOZ, CAROLINA DEMARCHI. Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density. PSYCHONEUROENDOCRINOLOGY, v. 98, p. 6-10, DEC 2018. Web of Science Citations: 2. (12/24727-4, 12/24002-0, 16/03572-3)
NOVAES, LEONARDO SANTANA; DOS SANTOS, NILTON BARRETO; DRAGUNAS, GUILHERME; PERFETTO, JULIANO GENARO; CARLOS LEZA, JUAN; SCAVONE, CRISTOFORO; MUNHOZ, CAROLINA DEMARCHI. Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats. Neuroscience, v. 393, p. 273-283, NOV 21 2018. Web of Science Citations: 5. (12/24727-4, 10/13843-8, 16/03572-3, 12/24002-0)
FALQUETTO, BARBARA; THIEME, KARINA; MALTA, MARILIA B.; ROCHA, KARINA C. E.; TUPPY, MARINA; POTJE, SIMONE R.; ANTONIALI, CRISTINA; RODRIGUES, ALICE C.; MUNHOZ, CAROLINA D.; MOREIRA, THIAGO S.; et al. Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson's disease. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 22, SEP 2020. Web of Science Citations: 0. (19/01236-4, 18/05426-0, 19/00065-1, 18/07087-8, 16/03572-3, 15/23376-1, 15/11268-0)
BATTAGELLO, DANIELLA S.; DRAGUNAS, GUILHERME; KLEIN, MARIANNE O.; AYUB, ANA L. P.; VELLOSO, FERNANDO J.; CORREA, RICARDO G.. Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission. Clinical Science, v. 134, n. 16, p. 2137-2160, AUG 2020. Web of Science Citations: 2. (17/16549-2, 17/17998-5, 19/05641-0)
DRAGUNAS, GUILHERME; WOEST, MANON E.; NIJBOER, SUSAN; BOS, SOPHIE T.; VAN ASSELT, JANET; DE GROOT, ANNE P.; VOHLIDALOVA, EVA; VERMEULEN, CORNEEL J.; DITZ, BENEDIKT; VONK, JUDITH M.; et al. Cholinergic neuroplasticity in asthma driven by TrkB signaling. FASEB JOURNAL, v. 34, n. 6, p. 7703-7717, JUN 2020. Web of Science Citations: 0. (18/18762-8)
(References retrieved automatically from State of São Paulo Research Institutions)
LOPES, Dielly Catrina Favacho. Participação do receptor GPER-1 na neuroproteção mediada por estrógeno em modelo de isquemia por privação de glicose/oxigênio em células corticais cerebrais.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/51409-8)
NOVAES, Leonardo Santana. Proteção conferida pelo enriquecimento ambiental na ansiedade induzida por estresse: a importância da sinalização via GR, ERK e CREB no complexo amigdalóide basolateral de ratos.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/13843-8)
DUQUE, Erica de Almeida. Efeito dos glicocorticóides na resposta inflamatória induzida por LPS em cultura de células primárias fronto-corticais de ratos neonatos.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/13932-0)
BATALHOTE, Rafaela Florindo Pestana Ferrão. Estudos da transmissão neuromuscular e do músculo esquelético em um modelo experimental de Esclerose Múltipla em camundongos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/50119-9)