CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo (ICB/USP). Holds a degree in Biochemistry-Pharmacy from São Paulo State University (UNESP, 1999) and a PhD in Sciences (Pharmacology) from the University of São Paulo (2005), including sandwich training at Complutense University of Madrid (2002) and Stanford University (2004). Completed postdoctoral training at the University of São Paulo (2006) and Stanford University (20062009). Research focuses on Pharmacology, with emphasis on Neuroscience, Neuroendocrinology, Neuroinflammation, and Biochemical and Molecular Pharmacology. (Source: Lattes Curriculum)
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Recent global events, such as the COVID-19 pandemic, social crises, and increasing inequality, have heightened exposure to stress across populations, leading to a troubling rise in psychiatric conditions like anxiety, depression, and PTSD. These disorders are already the leading causes of disability in Brazil and worldwide. Glucocorticoids (GCs), vital mediators of the stress response, si…
Leaky gut syndrome, characterized by increased intestinal permeability, has been linked to a myriad of health issues, including autoimmune diseases, metabolic disorders, and neurological conditions. Emerging evidence suggests that stress-induced dysbiosis, alterations in the composition of the gut microbiota, plays a crucial role in exacerbating gut permeability. However, the precise mech…
With the demonstration of the protective and antioxidant effects of estrogen (E2), the female sex hormone, in several pathologies, including the central nervous system (CNS), it has become mandatory to better comprehend its actions in the body, including in males. Clinical and experimental studies show such actions of E2 in stroke, the second leading cause of death and disability worldwid…
Anxiety-related disorders are common among psychiatric patients and are widely present in studies focusing on stress. In addition to the long-lasting anxiety behavior, impaired extinction of learned fear is associated with the development of post-traumatic stress disorder, one of the most debilitating stress-related disorder. The amygdala is a fundamental brain structure essential for beh…
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer's, Multiple Sclerosis and Parkinson's Disease. On the other side, the spread o…
(Only some records are available in English at this moment)
Adolescence represents a critical neurodevelopmental window characterized by intense synaptic plasticity and functional remodeling of corticolimbic circuits involved in emotional, cognitive, and neuroendocrine regulation. During this period, the proper integration between the medial prefrontal cortex, hippocampus, amygdala, and the hypothalamic-pituitary-adrenal (HPA) axis is essential fo…
Prolonged periods of stress may cause or potentiate pathologies. Stress activates the hypothalamic-pituitary-adrenal axis (HPA axis), ultimately releasing glucocorticoid hormones (GCs) which activate mineralocorticoid (MR) and glucocorticoid (GR) receptors. These receptors will mediate rapid and delayed responses to stress and the formation and maintenance of aversive memories. MR and GR …
Cardiovascular diseases are the leading cause of death in the world and include cerebrovascular diseases such as cerebrovascular accident (CVA). Most of the risk factors for stroke are modifiable, but non-modifiable factors, such as the individual's sex and age, interfere with their predisposition to suffer the accident. Epidemiological studies suggest that estrogen (mainly 17²-estradiol)…
(Only some records are available in English at this moment)
Glucocorticoids (GCs), like cortisol in humans, are steroid hormones essential for endocrine regulation and adaptation to stress. They interact with specific receptors, such as glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs), affecting processes ranging from neuronal differentiation to mood control and cognition. Prenatal exposure to synthetic glucocorticoids, such as…
Throughout life, it is inevitable to experience stressful situations; in some cases, brain structures such as the hypothalamus, amygdala, and hippocampus (HP) are affected, which can trigger or worsen anxiety disorders and impair memory processing and learning. Glucocorticoid hormones (GCs), released by activation of the hypothalamic-pituitary-adrenal axis (HPA axis), are the main mediato…
Nas últimas décadas, os vetores baseados em vírus recombinantes adeno-associados (AAV) têm sido muito usados como ferramenta para a transferência de genes em terapias, algumas já aprovadas, para o tratamento de doenças, incluindo o sistema nervoso central. Isto se dá pela capacidade desses vetores infectar células que não estão em processo de replicação, como os neurônios, astrócitos e mi…
(Only some records are available in English at this moment)
Stress is a vital physiological response for survival, but excessive exposure can increase the risk of developing psychiatric disorders. The hypothalamic-pituitary-adrenal (HPA) axis plays a crucial role in the stress response, mediating the release of glucocorticoid hormones (GCs) that modulate gene expression and influence cognition, emotion, mood, and immunity. During offspring neurode…
Stress constitutes a significant risk factor for psychiatric disorder development, such as post-traumatic stress disorder (PTSD). Some of PTSD's characteristic symptoms are impaired fear extinction and avoidance. The neurobiological mechanisms governing the fear extinction deficit and avoidance are extensively studied in rodent models through Pavlovian and instrumental conditioning. The m…
Neuroinflammation is a crucial factor in the development of neurologic diseases such as Alzheimer's disease (AD). Microglia play an essential role in the neuroinflammatory process since they can produce pro-inflammatory cytokines and are also responsible for amyloid beta clearance in AD patients. Mitochondrial dysfunction can trigger the release of mitochondrial damage-associated molecula…
The bidirectional communication between the gastrointestinal tract (GI) and the brain has gained attention as a therapeutic target for psychiatric disorders, such as depression, anxiety, and stress-related disorders. The vagus nerve is a critical component of the autonomic nervous system implicated in the gut-to-brain communication. Subcutaneously vagal stimulation has been increasingly u…
(Only some records are available in English at this moment)