CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the Federal University of Ceará (1991), Master of Sciences in Medicine (Nephrology) from the Federal University of São Paulo (1997), specialization in Transplantation Immunology at the University of Tours (Diplome des Etudes Appronfodies, France, 1997-1999), PhD in Medicine (Nephrology) by the Federal University of São Paulo (2000), postdoc at Imperial College London (2000-2003) and habilitation (Livre Docencia) at the Federal University of São Paulo (Medicine) in 2006. He is currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). He was Visiting Professor at the University of Tours, France in 2006. The laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity and allo. Full member of São Paulo Research Academy.Full member of Brazilian Academy of Sciences. CNPq 1A grantee award. Deputy Provost at the USP Graduate Office (2022-2023). (Source: Lattes Curriculum)
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Infectious diseases continue to be a major global public health problem, causing high levels of morbidity and mortality, despite the development of treatments and vaccines that has been achieved. In addition to diseases caused by reemerging agents, which cause problems even after their apparent eradication, more than 50 new infectious diseases have recently been identified worldwide, many…
The project focuses on investigating the immunological and inflammatory mechanisms that connect the skin, intestine, and other peripheral organs, with particular emphasis on the cellular and molecular pathways involved in chronic inflammatory and tumor-related diseases.The interconnection between the skin, intestine, and kidneys in inflammatory contexts highlights the skin's ability to in…
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
(Only some records are available in English at this moment)
O evento já está no 11 edição. tem 4 linhas temáticas: A: Resilience and Adaptation for Sustainable Agri-Food Systems; B: Strenghening Resilience by Drug Development and Innovative Medical Treatments; C: Green Innovation and Circular Economy forLife and Food e D: Human Resilience and Climate Justice (AU)
Saudemos as vozes e as memórias dos mais de 5 mil povos indígenas do mundo! No Brasil, um dos países mais multilíngues do planeta, existem mais de 175 línguas originárias, que resistem a um longo processo de apagamento e constituem um imenso patrimônio a ser conhecido e fortalecido para que não desapareça.Ao longo de milênios, os povos originários de todos os continentes desenvolveram uma…
Cisplatin is a potent antitumoral drug for diverse tumor types. However, its nephrotoxic adverse effects limit its clinical use in cancer therapy. Faced with this, several non-pharmacological approaches have been studied to minimize cisplatin-induced renal inflammation. One of these non-pharmacological approaches is caloric restriction, which several studies have demonstrated to be effici…
(Only some records are available in English at this moment)
The growing pollution caused by nanoplastics has become a global environmental threat, with direct impacts on ecosystems, living organisms, and potential risks to human health. Recent evidence indicates that these particles are capable of crossing biological barriers, accumulating in sensitive cellular microenvironments, and inducing toxic and inflammatory effects, thereby compromising es…
Plastic pollution is an emerging global health challenge, with nanoplastics (NPs) - plastic fragments smaller than one micrometer - increasingly detected in air, water, and human tissues. Due to their small size and chemical reactivity, NPs can cross biological barriers, accumulate inside cells, and interfere with fundamental processes such as metabolism, oxidative balance, and inflammati…
Acute kidney injury (AKI) is a serious clinical condition associated with high mortality and morbidity, developing in approximately 15% of patients admitted to intensive care units. It is characterized by the abrupt loss of renal function and currently lacks effective therapeutic interventions. At the cellular level, several organelles such as mitochondria, endoplasmic reticulum (ER), and…
(Only some records are available in English at this moment)
Diabetic kidney disease (DKD) is a serious microvascular complication that develops in patients with type 1 (T1D) or type 2 (T2D) diabetes and may be related to the prevalence of end-stage renal disease, which requires dialysis or renal replacement therapy. In DKD, the proximal tubular epithelial cells (PTECs), due to excess sodium and glucose in the filtrate, present a more pronounced O2…
The hypoxic response in cells and tissues is mediated by hypoxia-inducible transcription factors (HIF), among which HIF-1¿ plays a key role in metabolic changes in response to oxygen availability. Macrophages, cells of the immune system, are present in all tissues of the body and accumulate in ischemic/hypoxic areas, worsening tissue injury by producing reactive oxygen species and other t…
MAIT cells are T lymphocytes V±7.2+CD161hiMR1+CD4-CD3+ that present semi-invariant chains in the TCR receptors and were initially described in mucosal regions. From this description, they were termed Mucosal-Associated Invariant T cells (MAIT cells). In these regions, under homeostatic conditions, they respond to metabolites from the riboflavin biosynthesis pathway (5-OP-RU) produced by c…
(Only some records are available in English at this moment)
IgA nephropathy (IgAN) is the most common primary glomerulopathy worldwide and a major cause of chronic kidney disease, driven by the production of undergalactosylated IgA1 (Gd-IgA1), formation of anti-Gd-IgA1 autoantibodies, and mesangial immune complex deposition. Increasing evidence implicates the gut-kidney axis in IgAN pathogenesis, suggesting that dysbiosis and altered mucosal immun…
O vírus linfotrópico de células T humanas tipo 1 (HTLV-1) é um retrovírus responsável por infectar milhões de pessoas em todo o mundo. Indivíduos infectados podem desenvolver doenças inflamatórias ou neoplásicas, como a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a leucemia/linfoma de células T do adulto (ATLL), respectivamente. Após a infecção, o vírus pode …
CD8¿ T cells are essential for immune recognition of foreign antigens and rely on glycolysis, fueled by NAD, to support their activation and proliferation. SARM1, a TLR adaptor protein known to degrade NAD, shows a dynamic expression depending on the activation state of CD8¿ T cells. We reasoned that SARM1 may regulate CD8¿ T cell function through NAD metabolism. Therefore, we will invest…
(Only some records are available in English at this moment)
Initially described for their role in taste and their abundant presence in oral cavity cells, taste receptors are chemoreceptors activated by environmental molecules that generate a response in the form of an electrical impulse, which is processed by the nervous system and creates the perception of taste. With the advance of studies on taste receptors, their presence in ectopic regions wa…
Cutaneous melanoma is the leading cause of death from skin cancer worldwide and shows high resistance to radiotherapy and chemotherapy, indicating the need for alternative treatments. Tumor cells consume methionine avidly, and restricting this amino acid has been effective in hindering tumor growth in various models. Methionine is an essential amino acid involved in several metabolic path…
The gut microbiota has several immunoregulatory mechanisms that induce the host's immune tolerance against the microbiome throughout life. These organisms use fibers from the diet as nutrients for their metabolic fermentation, generating different types of shortchain fatty acids (SCFAs) as metabolic by-products. Among them, butyrate has been shown to induce Tregs, and its oral administrat…
(Only some records are available in English at this moment)