graduation at Odontologia from Universidade Estadual de Campinas (1990), master's at Odontology from Universidade Estadual de Campinas (1993) and doctorate at Odontology from Universidade Estadual de Campinas (1996). Has experience in Odontology, acting on the following subjects: fatty acid synthase, patologia bucal, ácido graxo sintase, câncer bucal and melanoma. (Source: Lattes Curriculum)
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Fatty acid synthase (FASN) is the anabolic enzyme responsible for the endogenous synthesis of fatty acids. Its expression and activity is abnormally high in several human malignancies, including oral squamous cell carcinomas (OSCC). It has been consistently demonstrated that the expression of FASN is associated with higher rates of recurrence, metastatic dissemination, and poor prognosis …
Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis 01 the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers including cutaneous melanoma, in which its levels of expression are associated with poor prognosis and depth o…
Oral squamous cell carcinoma (OSCC) is the most common head and neck neoplasia and usually affects male patients, over 50 years of age, smokers and alcoholics, with a predilection for the lateral border region of the tongue, mouth floor and lower lip. Despite of all the advance in the knowledge of the OSCC's biology, the survival rates remain around 55% in 5 years, mainly due to high rate…
Fatty acid synthase (FASN) is the main enzyme involved in neoplastic lipogenesis and recently suggested as a metabolic oncoprotein by promoting the growth and survival of tumor cells, where its expression is generally high. Several malignancies have elevated expression and activity of FASN, including oral squamous cell carcinoma (SCC), where FASN is associated with tumor aggressiveness, m…
Oral squamous cell carcinoma (SCC) represents more than 90% of malignant neoplasms affecting the oral cavity and, despite recent advances in treatment strategies, remains a challenging health problem around the world. The treatment of oral SCC is usually based on surgery or radiotherapy, with or without concomitant chemotherapy, and the survival rates are around 50% in 5 years, largely du…
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| 6 / 3 | Completed research grants |
| 20 / 6 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 27 / 9 | All research grants and scholarships |
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CV Lattes
ORCID