Ph.D. in Oncology from the Fundação Antônio Prudente - AC Camargo Cancer Center (2014), MSc in Genetics from the Graduate Program in Genetics, Federal University of Paraná (2009) and a degree in Biological Sciences from the Federal University of Paraná (2006). Has experience in the area of genetics, with an emphasis in Human Genetics and Oncogenetics, and the area of genomics. (Source: Lattes Curriculum)
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The genetic diagnosis of individuals at risk for hereditary cancer predisposition syndromes is performed through next-generation sequencing (NGS) of panels containing ten to hundreds cancer predisposition genes (CPGs). A significant part of genetic tests present uncertain results, with the identification of variants of unknown clinical significance (VUS), a finding that represents a major…
Recent advances in genomics have enabled the recognition of several novel cancer predisposing genes. Although genetic screening is currently well established for more common hereditary cancers, there is a number of rare tumors (annual incidence of less than 6 per 100,000 individuals) that are highly associated with cancer syndromes, but are often neglected due to its infrequency. The iden…
Recent advances in genomics have enabled the recognition of several novel cancer predisposing genes. Although genetic screening is currently well established for more common hereditary cancers, there are a number of very rare tumors (annual incidence of less than 6 per 100,000 individuals) that are highly associated with cancer syndromes, but are often neglected due to its infrequency. Th…
MUTYH-Associated Polyposis (MAP) is an autosomal recessive disease caused by alterations in the MUTYH gene, accounting for 0.7% of all colorectal cancers (CRC) and 13% of colorectal polyposis. The MUTYH gene is part of the DNA base excision repair system and, when mutated, leads to G:C - T:A transversions in several genes, including KRAS, often generating the somatic mutation c.34G>T; G12…
Currently, the genetic diagnosis of individuals at risk for hereditary cancer predisposition syndromes (HCPS) is carried out through the sequencing of a new generation of multigenic panels containing from ten to a hundred cancer predisposition genes (GPC). Recent studies in the literature and in our group show that a small portion of patients with SPHC has pathogenic / probably pathogenic…
Recently, a study of our group evaluated the occurrence of sarcomas in a suspected Lynch Syndrome (LS) cohort and identified three patients in whom the tumor etiology was associated with this syndrome. In this study, we identified another eleven patients as having sarcomas and colorectal tumors in the same individual or in individuals from the same family. Thus, the present study aims to …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 5 / 5 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
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CV Lattes
ORCID