CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Universidade Federal do Paraná (1979), master's at Clinical Medicine from Universidade Federal de São Paulo (1986) and doctorate at Clinical Medicine from Universidade Federal de São Paulo (1989). Has experience in Medicine, acting on the following subjects: cabeça e pescoço, câncer, boca, carcinoma and tratamento. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Las nuevas caras del cáncer |
| The new faces of cancer |
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| News published in Agência FAPESP Newsletter about the researcher |
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| TITULO |
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Oral cavity and oropharynx cancers develop in sites with visual access; despite that, most patients are diagnosed with advanced disease. Finding an ideal biomarker for disease early diagnosis may be challenging, due to the molecular complexity of head and neck carcinomas, in which carcinogenesis may be influenced by diverse risk factors, such as tobacco, alcohol consumption and HPV infect…
Although there have been several advances in research and improvements in oral squamous cell carcinoma (OSCC) treatments, the survival rate at 5 years from diagnosis is still about 50%. The excessive consumption of alcohol is prominent risk factor in oral cancer. The cancer progression does not depend solely on cancer cell-autonomous defects, but also on the dynamic crosstalk among the co…
Worldwide, more than 550,000 new cases of head and neck cancer (HNC) occur each year, resulting in approximately 300,000 deaths annually. It is the 6th most common cancer in both Europe and South America. A major reason for the high mortality rate for this cancer is the late stage of diagnosis for many patients. Accurate assessment of the prognosis of HNC cases also allows for appropriate…
INCiTO-INOTE will continue to support the scientific program previously created by the INCiTO, exploring bench-to-bedside-to-bench concepts, in order to face the challenges that are still limiting cancer prevention, diagnosis and treatment. The Institute will explore its large experience in genetics, epigenetics “comics”, bioinformatics and biomarkers to focus in areas where it can be wor…
Mucoepidermoid carcinoma of salivary gland (CMGS) have a great variability in thebiological behavior and its treatment depends both clinical and pathological prognosticfactors. One the most well-established prognostic factors for CMGS is the histological gradeof malignancy, which represents the morphological grading of tumor biologicalcharacteristics, despite its subjectivity, has proved …
The development of breast cancer metastasis is the main responsible for the observed high mortality rate in patients with breast cancer. The presence of tumor cells in the axillary lymph nodes, the first metastatic site in the breast, is the most effective prognostic factor of tumor recurrence. Genomic and gene expression studies have showed evidences that the molecular alterations that c…
(Only some records are available in English at this moment)
In 2020, approximately 1.5 million people were diagnosed with head and neck cancer, resulting in around 500,000 deaths. Although immutable patient characteristics contribute significantly to this mortality, high-quality medical treatment, particularly the surgeon's role, can considerably reduce the number of deaths. Evidence indicates that the surgeon's experience and adherence to best su…
The length of hospital stay is an important indicator in the context of health, both for patientsand for the health system. This length of stay is defined as the duration of hospitalizationfrom the moment of admission to hospital discharge. Thus, it is a fundamental indicator fordetermining different treatment policies and resource allocation, demonstrating the relevanceof this informatio…
The digitization of histological slides favors the migration of diagnostic practice to a fully digital environment. In this context, computer-aided diagnosis (CAD), with a focus on quantitative analysis, opens paths for diagnosis through artificial intelligence (AI) driven by technological development that favors strategies based on neural networks that uses images in this process. This s…
Introduction: Oral Squamous Cell Carcinoma (OSCC) is the fifth malignant neoplasia most common worldwide and affects mostly men between the fifth and sixth decade of life. However, a higher occurrence among young people has recently been reported in different countries of the world, and the clinical and biological behavior of these tumors is still a matter of discussion. Aim: To compare t…
Thyroid nodules are common in adult population, being detected in up to 70% of cases by ultrasound tests. However, current diagnostic methods have limitations in distinguishing malignant from benign follicular lesions, resulting in a significant number of potentially preventable surgeries. Thus, molecular diagnostic and prognostic tools of thyroid cancer are of great interest. In a previo…
Mucoepidermoid carcinoma of salivary gland ( CMGS ) has a great variability in the biological behavior and its treatment depends on both clinical and pathological prognostic factors. One the most well-established prognostic factors for CMGS is the histological grade of malignancy, which represents the morphological grading of tumor biological characteristics, despite its subjectivity, has…
(Only some records are available in English at this moment)
The differential diagnosis of thyroid nodules is challenging, and many patients are submitted to unnecessary surgical procedures. During the post-doctoral period, we developed a diagnostic algorithm based on DNA methylation (bisulfite pyrosequencing) and tested an mRNA-based tool (RT-qPCR) in biopsies of thyroid lesions. Additionally, we characterized microRNAs (miRNAs) potentially regula…
Although the prevalence of oral squamous cell carcinoma (OSCC) has increased worldwide in young patients, there is no consensus regarding its etiological factors. Nevertheless, previous studies have proposed that high-risk human papillomavirus (HR-HPV) may be a promoting agent of oral carcinogenesis in this age group. Preliminary results: Laser-capture microdissection followed by liquid c…
| 3 / 3 | Ongoing grants |
| 20 / 13 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 13 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 41 / 27 | All research grants and scholarships |
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