Graduated in Dentistry from the Bauru School of Dentistry (FOB), USP (1992), Master in Dentistry, area of Periodontics, FOB-USP (1995) and Ph.D. in Functional and Molecular Biology from UNICAMP (1999) and Specialist in Orofacial Harmonization (2021). She was (2011-2014) Member of the Awards Review Committee of the International Association for Dental Research (IADR) and Member of the Board of the European Organization for Research in Caries (ORCA). She was Chair of the IADR Cariology group (2019-2020) and coordinator of the Health Area II (Dentistry) at FAPESP (2018-2022. He was Head of the Department of Biological Sciences (2006-2010) and President of the Research Committee (2014-2018) at FOB-USP. She was Associate Editor of the Journal of Applied Oral Sciences and the International Journal of Dentistry. She is currently Full Professor at the Department of Biological Sciences and Dean of FOB-USP, 1A researcher at CNPq and Editor of the Monographs in Oral Science series (Karger). She has expertise in Dentistry, with emphasis on Cariology, Oral Biochemistry and Orofacial Harmonization, acting on the following topics: fluorides, dental fluorosis, dental caries, dental erosion, bacterial biofilm, acquired film, toxicology, proteomics and autologous platelets aggregates. Member of the Brazilian Academy of Dentistry (chair 69) since 2021. Received more than 70 awards, highlighting the Basil Bibby Young Investigator Award in Cariology (IADR, 2008) and the IADR Distinguished Scientist Award H. Trendley Dean Memorial Award (2014). She has published 5 books and more than 400 articles in journals with a selective editorial policy. She presents h factor = 41, with 7050 citations (WOS). She is among the most influent researchers of the world (Stanford University ranking; Ioannidis et al., Plos Biol, 2020) and of São Paulo University (position 31/164 (https://jornal.usp.br/universidade/pesquisadores-da-usp-estao-entre-os-mais-influentes-da-ciencia-mundial/). (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| White smile |
| Por una blanca sonrisa |
| News published in Agência FAPESP Newsletter about the researcher |
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Dentistry and speech therapy clinics, as well as research laboratories, have several high-cost equipment, many of which are available on the multi-user platform, used in the development of clinical research activities and in the laboratory environment of this university. With several cases of power supply interruptions, these equipment are vulnerable and susceptible to electrical damage. …
The presence of the acquired enamel pellicle (AEP) is one of the protective factors against erosive tooth wear (ETW) and dental caries. Among the AEP proteins with enamel binding potential and acid-resistant properties, cystatin, hemoglobin (Hb) and statherin have been recently identified by our group. Modification of the protein profile of the AEP by the incorporation of some proteins ca…
The presence of the acquired enamel pellicle (AEP) is one of the protective factors against erosive tooth wear (ETW) and dental caries. Among the AEP proteins with enamel binding potential and acid-resistant properties, cystatin, hemoglobin (Hb) and statherin have been recently identified by our group. Modification of the protein profile of the AEP by the incorporation of some proteins ca…
(Only some records are available in English at this moment)
Resveratrol is a polyphenol naturally produced by 72 different species of plants, with emphasis on grapes, vegetables, peanuts, soybeans and pomegranates. It has been widely studied for its different beneficial health effects, since it has antioxidant, anti-inflammatory, immunomodulatory and neuroprotective properties, which means that its consumption is associated with a reduction in cho…
Cystatins are reversible inhibitors of cysteine peptidases present in all forms of life. Human cystatin B has recently been identified in the acquired dental enamel film as an acid-resistant protein, which demonstrates its potential to be used in dental products for protection against caries and tooth erosion. However, the cost of this cystatin is expansive, which makes its inclusion in c…
Recently, procedures involving "Acquired Pellicle Engineering" have been proposed by our group as a new strategy to control dental erosion. The incorporation of active substances in rinse solutions or gels for topical application could favor the ability of the acquired enamel pellicle to protect against erosion. Preliminary experiments of our group revealed that CaneCPI-5, a protein clone…
(Only some records are available in English at this moment)
Sodium trimetaphosphate (TMP) has been studied for its incorporation into fluoride vehicles for topical use. It is known that it promotes a significant increase in the preventive and therapeutic potential of fluoride. The incorporation of proteins (eg, CaneCPI-5) into the acquired enamel pellicle (AEP) has favored its ability to protect against erosion. In this context, associating CaneCP…
The presence of acquired enamel pellicle (AEP) is one of the protective factors against erosive tooth wear (ETW) and dental caries. With the advancement of omics techniques, acid-resistant proteins have been identified in the AEP, which has stimulated "acquired pellicle engineering" procedures, focused on enriching this integument with proteins with high capacity to bind to hydroxyapatite…
In the first part of the project, carried out at the University of Toronto (BEPE), the design, characterization and evaluation of new resins functionalized with methacrylate-DNA conjugates hybridized with CaneCPI-5-, Stn15pSpS- or Hb-DNA will be carried out. DNA strands will be covalently linked to commercially available methacrylate and to CaneCPI-5, Stn15pSpS or Hb, using standard bioco…
(Only some records are available in English at this moment)
This research aims to evaluate the dose-response effect of xylitol, associated or not to fluoride (F), in reducing the demineralization of enamel in vitro. For such, 120 bovine enamel specimens will be prepared (4 mm x 4 mm x 3 mm), polished, and selected by surface hardness (initial SH). The specimens will be submitted to a pH cycling model for 7 days. The experimental groups to be evalu…
White spot lesion (LMB) can be defined as the primary clinical manifestation of tooth decay, whose milky white, dull clinical appearance is the result of a loss of subsurface mineral structure. Based on the results of previous studies supported by FAPESP, (Process 2018/21944-0 and Process 2018/24904-0) and continuing these studies, the objective of this work will be to develop an in vitro…
The presence of acquired enamel pellicle (AEP) is one of the protective factors against erosion and tooth decay. The alteration of the PAE protein profile, through the incorporation of certain proteins, can increase the protection against acid attacks and alter the initial bacterial colonization of the biofilm, modifying its structure. Statherin is an important salivary protein, which, du…
(Only some records are available in English at this moment)
The formation of a white spot lesion (WSL) around orthodontic accessories is considered a reversible iatrogenesis, with a high frequency of occurrence. The presence of different bacteria and their degrees of pathogenicity in dysbiotic biofilm related to dental caries is recent. In addition, no studies relate the action of a high fluoride concentration on the cariogenic biofilm in vivo. Id…
Resveratrol is a polyphenol naturally produced by different plant species, which has been widely studied for its different beneficial health effects, since it has antioxidant, anti-inflammatory, immunomodulatory and neuroprotective properties. Its consumption is associated with a reduction in cholesterol levels, obesity, cardiovascular risk and prevention of diabetes, in addition to havin…
Recent studies have shown that the use of DNA goes beyond its biological role. It has recently been used as a building block for materials due to its high specific molecular recognition properties. The desirable molecular properties of DNA, such as base pairing, precise sequence control, repair capability, ease of modification and functionalization, and biocompatibility allow for applicat…
The use of DNA as a building block for the development of polymeric biomaterials represents a major advance in the field of nanomedicine. The desirable molecular properties of DNA, such as base pairing, precise sequence control, repair capability, ease of modification and functionalization, and biocompatibility allow for applications in drug delivery and as scaffolds. DNA nanostructures c…
The acquired pellicle (AP) is a film that results from selective adsorption of proteins, glycoproteins and lipids on the tooth surface. The AP forms a protective interface on the tooth surface that reduces the demineralizing effects of acids. Recently, a statherin-derived peptide (Stn15pSpS) was shown to protect against initial enamel erosion in vitro and in vivo. However, the exact mecha…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 43 / 30 | Completed research grants |
| 12 / 12 | Ongoing scholarships in Brazil |
| 129 / 95 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 15 / 15 | Completed scholarships abroad |
| 205 / 158 | All research grants and scholarships |
| Associated processes | |
CV Lattes
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