Joel Claudio Heimann

• Abstract

  Barker and colleagues found an association between unfavorable environment, particularly inadequate maternal nutrition during the perinatal period with a predisposition to cardiovascular disease, metabolic and endocrine diseases in adulthood. Several epidemiological studies have found that the nutritional prenatal and early postnatal may be associated with glucose intolerance, insulin res…

  Low salt intake during gestation: evaluation of the epigenetic mechanisms responsible for the low birth weight and insulin resistance in adult offspring, AP.R

• Abstract

  Several epidemiological studies show that hypertension in adulthood is associated with the mother's diet during pregnancy. In humans, the reduced number of glomeruli is related to hypertension, cardiovascular disease and kidney disease in adulthood. In our laboratory, Alves-Rodrigues Jr. et.al studied the adult male offspring from Wistar rats which were fed a low salt diet (HO- 0,15% NaCl…

  Sodium chloride overload or restriction during pregnancy: cardiac and renal structural alterations in the neonate, AP.R

• Abstract

  To identify possible epigenetic alterations caused by the consumption of food with high levels of NaCl (salt), and if these alterations could affect germ cell lineage leading to next generation transmission, configuring transgenerational epigenetic alteration, Wistar female rats, on gestational phase, will be submitted to high-sodium concentration diet. The offspring will receive normosod…

  Transgenerational epigenetic effect of high-sodium intake in Wistar rats, AP.R

(Only some records are available in English at this moment)

• Abstract

  Hypertension (AH) is a well-established risk factor for the development of cardiovascular and renal diseases (CVR). The collaborative study group recently proposed a contributor to the aetiology of HA mediated by salt overload: Lysine Specific Demethylase-1 (LSD1). The candidate worked with this same group of studies and demonstrated that in mice, LSD1 deficiency accelerates the increase …

  Mechanisms for the key role of the LSD1 gene in cardiovascular and renal effects associated with a high salt diet, BP.IC

• Abstract

  Hypertension (HTN) is a well known risk factor for the development of cardiovascular and renal (CVR) diseases. The collaborating group recently proposed a novel contributor to the etiology of HTN mediated by salt: Lysine Specific Demethylase 1 (LSD1). The candidate worked with this group and demonstrated that in mice, the deficiency of LSD1 accelerates the increase of blood pressure (BP) …

  New concepts for the fundamental role of LSD1 gene in cardiovascular and renal effects associated to salt dietary, BP.PD

• Abstract

  The cardiac hypertrophy is an apparition that follow hypertension, having one of the highlight motive the high salt intake, where it is observed a increased of structural and contract proteins of myocytes, being together with the enhanced of interstitial collagen.The high salt intake changes the running of the Renin-Angiotensin System (RAS), which is a homeostatic system that controls the…

  Evaluation of cardiac structural changes induced by salt overload in male Wistar rats, BP.IC

(Only some records are available in English at this moment)