Isis Do Carmo Kettelhut
CV Lattes
ResearcherID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences (Graduation Degree) by Júlio de Mesquita Filho São Paulo State University (1973), Degree in Biological Sciences (Bachelor Modality) by Júlio de Mesquita Filho São Paulo State University (1974), MA in Physiology from Ribeirão Preto Medical School - University of São Paulo (1976), PhD in Physiology, Ribeirão Preto Medical School - University of São Paulo (1980) and post doctorate at Harvard Medical School, Boston, USA (1985-1988). She is currently professor at the Department of Biochemistry and Immunology, Ribeirão Preto Medical School. She has experience in the areas of Biochemistry and Physiology, with emphasis on Endocrinology and Metabolism Control, acting on the following topics: hormonal control, neural nutrition and metabolism of proteins, lipids and carbohydrates. (Source: Lattes Curriculum)
- Neural, hormonal and nutritional control of autophagy, AP.TEM
Abstract
Autophagy is a ubiquitous catabolic process that causes intracellular degradation through vesicular engulfment of dysfunctional, damaged, or harmful cytoplasmic components. Although it is well established that autophagy and the Ub-proteasome system regulate cellular homeostasis, the exacerbation of these processes leads to muscle atrophy and several pathologies. Previous work from our l...
- Role and mechanism of action of anabolic stimuli on neuromuscular trophicity, AP.R
Abstract
Accumulating evidence suggests that the synapse between motoneurons and skeletal muscle fibers, the neuromuscular junction (NMJ), plays an integral role not only for muscle contraction but also for superior, metabolic muscle functions. This might be of particular relevance under a series of severe atrophic conditions, including age-related muscle loss (sarcopenia). The principal postsyn...
- Control of muscle mass by cAMP signaling pathway, AP.TEM
Abstract
In our previous thematic project, we have shown that the sympathetic nervous system through the beta 2-adrenoceptors activation inhibits the activity of ubiquitin-proteasome system (UPS), the major proteolytic system involved in muscle wasting. This effect is due to the suppression of "atrophy program" (atrophy-related genes or atrogenes) and involves the cAMP signaling pathway. However...
- Role of insulin and sympathetic nervous system in the control of glycerol-3-phosphate generation in white adipose tissue of rats, AP.R
(Only some records are available in English at this moment)
- Neural, hormonal and nutritional control of autophagy, BP.PD
Abstract
Urocortin 2 (Ucn2) is a peptide of 38 amino acids, member of the corticotrophin releasing factor (CRF) neuropeptide family. The skeletal muscle express both Ucn2 and its specific receptor CRF2R² (corticotrophin releasing factor 2² receptor), although this notary autocrine/paracrine action of this peptide, practically, nothing is known about its skeletal muscles actions (Reyes et al., 20...
- The role of the beta-arrestin signaling pathway in the control of cardiac muscle mass and cardiomyocytes culture of rodents, BP.PD
Abstract
The heart failure is one of the most prevalent cardiovascular disease in the world which could explain the great interest in the knowledge of the cardiac mass regulation. Our previous studies revealed the role of SNS in the regulation of protein metabolism in the heart through the inhibition of the Ub-proteasome and lysosomal /autophagic proteolytic activities, which are primarily invol...
- FOXO hyperacetylation as a mechanism of suppression of atrophy gene program induced by beta2-adrenergic signaling in rodent skeletal muscle, BP.PD
Abstract
The knowledge of therapeutic strategies able to counteract skeletal muscle atrophy is an important issue for human health. In previous studies, we have showed that b2-adrenoceptors (AR) activation regulates muscle protein metabolism through the suppression of the activity of ubiquitin (Ub)-proteasome system, the major proteolytic system involved in muscle wasting, and the expression of ...
- Intracellular mechanisms involved in anticatabolic effect of the epinephrine in skeletal muscle of fasted rats, BP.DR
(Only some records are available in English at this moment)
- FOXO hyperacetylation as a mechanism of suppression of atrophy gene program induced by beta2-adrenergic signaling in rodent skeletal muscle, BE.EP.PD
Abstract
The development of therapeutic strategies capable of inhibiting protein breakdown and preserving muscle mass is an important issue for human health. In previous studies, we have showed that beta2-adrenoceptors (AR) activation mitigates muscle atrophy through the suppression of the activity of ubiquitin (Ub)-proteasome (UPS) and autophagy-lysosomal (ALS) systems, the major proteolytic sy...
- The role of PDE4D5 in the beta-arrestin signaling pathway in the control of cardiac muscle mass and cardiomyocytes culture of rodents, BE.EP.PD
Abstract
The knowledge of mechanisms that regulate cardiac mass is of great relevancedue to the fact that nowadays many people suffer from cardiovascular diseases that leadto heart failure.Our previous results demonstrated that the sympathetic nervous system (SNS)regulates the metabolism of heart proteins through the inhibition of Ub-proteasome andlysosomal/autophagic proteolytic systems activit...
| 1 / 1 | Ongoing research grants |
| 14 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 4 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 22 |
| Citations | 369 |
| Cit./Article | 16.8 |
| Data from Web of Science | |
MANFREDI, L. H.; PAULA-GOMES, S.; ZANON, N. M.; KETTELHUT, I. C.. Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents. Brazilian Journal of Medical and Biological Research, v. 50, n. 12, 2017. Web of Science Citations: 3. (08/06694-6, 12/24524-6)
PEREIRA, MARCELO G.; SILVA, MEIRICRIS T.; CARLASSARA, EDUARDO O. C.; GONCALVES, DAWIT A.; ABRAHAMSOHN, PAULO A.; KETTELHUT, ISIS C.; MORISCOT, ANSELMO S.; AOKI, MARCELO S.; MIYABARA, ELEN H.. Leucine Supplementation Accelerates Connective Tissue Repair of Injured Tibialis Anterior Muscle. NUTRIENTS, v. 6, n. 10, p. 3981-4001, OCT 2014. Web of Science Citations: 16. (10/18287-6, 12/24524-6, 09/17667-2, 12/15276-9, 12/18861-0)
CASSOLLA, PRISCILA; UCHOA, ERNANE TORRES; MANSUR MACHADO, FREDERICO SANDER; GUIMARAES, JULIANA BOHNEN; RISSATO GAROFALO, MARIA ANTONIETA; BRITO, NILTON DE ALMEIDA; KAGOHARA ELIAS, LUCILA LEICO; COIMBRA, CANDIDO CELSO; KETTELHUT, ISIS DO CARMO; CARVALHO NAVEGANTES, LUIZ CARLOS. The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 465, n. 12, p. 1687-1699, DEC 2013. Web of Science Citations: 3. (10/11083-6, 08/06694-6, 10/11015-0, 09/07584-2)
PRZYGODDA, FRANCIELE; MANFREDI, LEANDRO HENRIQUE; MACHADO, JULIANO; GONCALVES, DAWIT A. P.; ZANON, NEUSA M.; BONAGAMBA, LENI G. H.; MACHADO, BENEDITO H.; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C. C.. Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism. Journal of Applied Physiology, v. 122, n. 5, p. 1114-1124, MAY 2017. Web of Science Citations: 2. (08/06694-6, 12/18861-0, 12/24524-6)
MACHADO, JULIANO; MANFREDI, LEANDRO H.; SILVEIRA, WILIAN A.; GONCALVES, DAWIT A. P.; LUSTRINO, DANILO; ZANON, NEUSA M.; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C.. Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v. 72, p. 40-50, MAR 2016. Web of Science Citations: 10. (12/24524-6, 11/11003-5, 12/51456-1, 12/05697-7, 12/18861-0)
KHAN, MUZAMIL MAJID; LUSTRINO, DANILO; SILVEIRA, WILLIAN A.; WILD, FRANZISKA; STRAKA, TATJANA; ISSOP, YASMIN; O'CONNOR, EMILY; COX, DAN; REISCHL, MARKUS; MARQUARDT, TILL; et al. Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease. Proceedings of the National Academy of Sciences of the United States of America, v. 113, n. 3, p. 746-750, JAN 19 2016. Web of Science Citations: 35. (10/11083-6, 12/51456-1, 12/05697-7, 12/24524-6)
FORESTO, CAMILA SILVA; PAULA-GOMES, SILVIA; SILVEIRA, WILIAN ASSIS; GRACA, FLAVIA APARECIDA; KETTELHUT, ISIS DO CARMO; PINHEIRO GONCALVES, DAWIT ALBIEIRO; MATTIELLO-SVERZUT, ANA CLAUDIA. Morphological and molecular aspects of immobilization-induced muscle atrophy in rats at different stages of postnatal development: the role of autophagy. Journal of Applied Physiology, v. 121, n. 3, p. 646-660, SEP 1 2016. Web of Science Citations: 3. (13/08553-9, 12/18861-0, 12/24524-6, 10/11015-0)
SILVEIRA, W. A.; GONCALVES, D. A.; GRACA, F. A.; ANDRADE-LOPES, A. L.; BERGANTIN, L. B.; ZANON, N. M.; GODINHO, R. O.; KETTELHUT, I. C.; NAVEGANTES, L. C. C.. Activating cAMP/PKA signaling in skeletal muscle suppresses the ubiquitin-proteasome-dependent proteolysis: implications for sympathetic regulation. Journal of Applied Physiology, v. 117, n. 1, p. 11-19, JUL 2014. Web of Science Citations: 16. (10/11083-6, 08/06694-6, 12/18861-0, 12/24524-6, 10/11015-0)
PAULA-GOMES, S.; GONCALVES, D. A. P.; BAVIERA, A. M.; ZANON, N. M.; NAVEGANTES, L. C. C.; KETTELHUT, I. C.. Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling. Hormone and Metabolic Research, v. 45, n. 12, p. 849-855, NOV 2013. Web of Science Citations: 31. (10/12206-4, 08/06694-6, 12/18861-0)
GRACA, FLAVIA A.; GONCALVES, DAWIT A. P.; SILVEIRA, WILIAN A.; LIRA, EDUARDO C.; CHAVES, VALERIA ERNESTANIA; ZANON, NEUSA M.; GAROFALO, MARIA ANTONIETA R.; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C. C.. Epinephrine depletion exacerbates the fasting-induced protein breakdown in fast-twitch skeletal muscles. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 305, n. 12, p. E1483-E1494, DEC 2013. Web of Science Citations: 9. (10/11083-6, 08/06694-6, 10/11015-0, 12/24524-6, 09/07584-2)
GONCALVES, DAWIT A. P.; SILVEIRA, WILIAN A.; LIRA, EDUARDO C.; GRACA, FLAVIA A.; PAULA-GOMES, SILVIA; ZANON, NEUSA M.; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C. C.. Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 302, n. 1, p. E123-E133, JAN 2012. Web of Science Citations: 41. (10/11083-6, 08/06694-6, 09/07584-2, 10/11015-0)
MANFREDI, L. H.; LUSTRINO, D.; MACHADO, J.; SILVEIRA, W. A.; ZANON, N. M.; NAVEGANTES, L. C.; KETTELHUT, I. C.. Adrenodemedullation activates the Ca2+-dependent proteolysis in soleus muscles from rats exposed to cold. Journal of Applied Physiology, v. 122, n. 2, p. 317-326, FEB 2017. Web of Science Citations: 1. (08/06694-6, 12/05697-7, 12/24524-6)
FERREIRA, GRAZIELLA NASCIMENTO; ROSSI-VALENTIM, RAFAEL; BUZELLE, SAMYRA LOPES; PAULA-GOMES, SILVIA; ZANON, NEUSA MARIA; RISSATO GAROFALO, MARIA ANTONIETA; FRASSON, DANUBIA; CARVALHO NAVEGANTES, LUIZ CARLOS; CHAVES, VALERIA ERNESTANIA; KETTELHUT, ISIS DO CARMO. Differential regulation of glyceroneogenesis by glucocorticoids in epididymal and retroperitoneal white adipose tissue from rats. ENDOCRINE, v. 57, n. 2, p. 287-297, AUG 2017. Web of Science Citations: 1. (13/08553-9)
GONCALVES, DAWIT A. P.; LIRA, EDUARDO C.; BAVIERA, AMANDA M.; CAO, PEIRANG; ZANON, NEUSA M.; ARANY, ZOLTAN; BEDARD, NATHALIE; TANKSALE, PREETI; WING, SIMON S.; LECKER, STEWART H.; et al. Mechanisms Involved in 3 `,5 `-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle. Endocrinology, v. 150, n. 12, p. 5395-5404, DEC 2009. Web of Science Citations: 29. (08/06694-6, 09/07584-2)
LIRA, EDUARDO C.; GONCALVES, DAWIT A. P.; PARREIRAS-E-SILVA, LUCAS T.; ZANON, NEUSA M.; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C. C.. PHOSPHODIESTERASE-4 INHIBITION REDUCES PROTEOLYSIS AND ATROGENES EXPRESSION IN RAT SKELETAL MUSCLES. MUSCLE & NERVE, v. 44, n. 3, p. 371-381, 2011. Web of Science Citations: 11. (08/06694-6, 09/07584-2)
BAVIERA‚ A.M.; ZANON‚ N.M.; NAVEGANTES‚ L.C.C.; MIGLIORINI‚ R.H.; KETTELHUT‚ I.C.. Chemical sympathectomy further increases muscle protein degradation of acutely diabetic rats. MUSCLE & NERVE, v. 38, n. 2, p. 1027-1035, 2008.
RUDOLF, RUEDIGER; KHAN, MUZAMIL M.; LUSTRINO, DANILO; LABEIT, SIEGFRIED; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C. C.. Alterations of cAMP-dependent signaling in dystrophic skeletal muscle. FRONTIERS IN PHYSIOLOGY, v. 4, 2013. Web of Science Citations: 13. (12/05697-7, 12/24524-6)
AHMADIAN, MARYAM; DUNCAN, ROBIN E.; VARADY, KRISTA A.; FRASSON, DANUBIA; HELLERSTEIN, MARC K.; BIRKENFELD, ANDREAS L.; SAMUEL, VARMAN T.; SHULMAN, GERALD I.; WANG, YUHUI; KANG, CHULHO; et al. Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity. Diabetes, v. 58, n. 4, p. 855-866, APR 2009. Web of Science Citations: 105.
NAVEGANTES‚ LCC; MACHADO‚ CR; RESANO‚ NMZ; MIGLIORINI‚ RH; KETTELHUT‚ IC. ß2-Agonists and cAMP inhibit protein degradation in isolated chick (Gallus domesticus) skeletal muscle. BRITISH POULTRY SCIENCE, v. 44, n. 1, p. 149-154, 2003.
BAVIERA, AMANDA MARTINS; ZANON, NEUSA MARIA; NAVEGANTES, LUIZ CARLOS C.; KETTELHUT, ISIS CARMO. Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle. Molecular and Cellular Endocrinology, v. 315, n. 1-2, p. 104-112, FEB 5 2010. Web of Science Citations: 31. (08/06694-6)
FRASSON, DANUBIA; BOSCHINI, RENATA POLESSI; CHAVES, VALERIA ERNESTANIA; SOARES MARTINS DOS SANTOS, MARIA EMILIA; GOMES, SILVIA DE PAULA; VALENTIM, RAFAEL ROSSI; RISSATO GAROFALO, MARIA ANTONIETA; CARVALHO NAVEGANTES, LUIZ CARLOS; MIGLIORINI, RENATO HELIOS; KETTELHUT, ISIS DO CARMO. The sympathetic nervous system regulates the three glycerol-3P generation pathways in white adipose tissue of fasted, diabetic and high-protein diet-fed rats. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 61, n. 10, p. 1473-1485, OCT 2012. Web of Science Citations: 8. (10/12206-4, 06/00448-8)
PORTO DECHANDT, CARLOS ROBERTO; FERRARI, GUSTAVO DUARTE; DOS SANTOS, JONATHAS RODRIGO; CORTES DE OLIVEIRA, JOSE ANTONIO; PATRICIO SILVA-JR, RUI MILTON; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; GARCIA-CAIRASCO, NORBERTO; ALBERICI, LUCIANE CARLA. Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy. FRONTIERS IN NEUROLOGY, v. 10, OCT 1 2019. Web of Science Citations: 0. (14/03989-6, 18/10089-2, 16/23509-4, 15/22327-7, 19/00849-2)
MACHADO, JULIANO; SILVEIRA, WILIAN A.; GONCALVES, DAWIT A.; SCHAVINSKI, ALINE ZANATTA; KHAN, MUZAMIL M.; ZANON, NEUSA M.; DIAZ, MAURICIO BERRIEL; RUDOLF, RUEDIGER; KETTELHUT, ISIS C.; NAVEGANTES, LUIZ C.. alpha-Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles. MOLECULAR METABOLISM, v. 28, p. 91-106, OCT 2019. Web of Science Citations: 0. (09/54014-7, 11/11003-5, 12/24524-6, 18/10089-2, 12/18861-0)
GONCALVES, DAWIT A.; SILVEIRA, WILIAN A.; MANFREDI, LEANDRO H.; GRACA, FLAVIA A.; ARMANI, ANDREA; BERTAGGIA, ENRICO; O'NEILL, BRIAN T.; LAUTHERBACH, NATALIA; MACHADO, JULIANO; NOGARA, LEONARDO; et al. Insulin/IGF1 signalling mediates the effects of beta(2)-adrenergic agonist on muscle proteostasis and growth. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 10, n. 2, p. 455-475, APR 2019. Web of Science Citations: 1. (18/10089-2, 12/18861-0, 12/24524-6, 10/11015-0)