Jose Butori Lopes de Faria

• Abstract

  Renal fibrosis is the final result of different renal insults. At late stages, it is associated with end stage renal disease (ESRD). Although knowledge on mechanisms involved in the progression of renal disease to fibrosis has advanced significantly treatment and prevention of this condition remain insufficient, since the number of people with ESRD continue to grow. Microvascular chronic …

  Contribution of AMPK pathway to renal fibrosis and pathogenesis of diabetic nephropathy and retinopathy, AP.TEM

• Abstract

  Hyperglycemia-induced oxidative stress causes an accumulation of extracellular matrix markers (ECM) that can progress to fibrosis and end stage renal disease, which is characteristic of diabetic nephropathy (DN). As part of our thematic project (2008/57560-0), we have observed that treatment with cocoa enriched in polyphenols as well as treatment with cocoa with a low polyphenol content w…

  Can theobromine stimulate SIRT1 (silent information regulator 1) and reduce Diabetes-associated oxidative stress and renal fibrosis?, AP.R

• Abstract

  Diabetes mellitus (DM) affects about 20 million of individuals in Brazil. Roughly, a third of these individuals will develop renal and retinal diseases. Although in the last decade the understanding of the pathogenesis and treatment of these conditions has advanced considerably, the number of individuals who develop end-stage renal disease and blindness secondary to diabetes is still risi…

  Effects of green tea (Camellia sinensis), cocoa and nitric oxide donor on diabetic nephropathy and retinopathy: contribution of the reduction of oxidative stress and inflammation and elevation of nitric oxide, AP.TEM

(Only some records are available in English at this moment)

• Contribution of irisin / AMPK to renal fibrosis in diabetes mellitus: an in vitro study, BP.TT

• Abstract

  Diabetic nephropathy (DN) is a serious and frequent complication in individuals with diabetes mellitus (DM). Clinical studies suggest that physical exercise is able to prevent and improve kidney disease in individuals with DM. Recent observations suggest that irisin, a myocin produced by muscle and stimulated by physical exercise, may be the link between muscle tissue and kidneys in renal…

  Does the elevation of irisin induced by physical exercise contribute to renal protection in experimental Diabetes?, BP.IC

• Abstract

  Renal fibrosis is the final result of different renal insults. At late stages, it is associated with End Stage Renal Disease (ESRD). Although knowledge on mechanisms involved in the progression of renal disease to fibrosis has advanced significantly treatment and prevention of this condition remain insufficient, since the number of people with ESRD continue to grow. Microvascular chronic …

  AMPK pathway contribution to renal fibrosis and pathogenesis of Diabetic Nefropathy and Retinopathy, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Oxidative stress induced by hyperglycaemia causes alteration in the glomerular filtration barrier, thereby leading to albuminuria, which is characteristic of diabetic nephropathy (DN). Podocytes are an important component of the integrity of the glomerular filtration barrier. Treatment with antioxidants diminishes diabetes-induced podocyte apoptosis and is therefore a potential therapeuti…

  Effect of early outgrowth cells in apoptosis of cultured podocytes exposed to high glucose or hydrogen peroxide, BE.EP.PD