Israel Tojal da Silva in research grants and scholarships supported by FAPESP.
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The use of molecular biomarkers has great potential to drive precision oncology. Although promising, they are not yet widely available in the clinical routine of most medical centers and their high cost can make them unaffordable for most patients. Thus, the development of new fast and low-cost approaches becomes increasingly necessary. In this context, the use of modern techniques of Art…
Immune based therapeutics such as checkpoint inhibitors have proven to work across several cancer types and the potential impact novel immuno-oncology targets can have on inducing anti-cancer responses, either as standalone, or as combination/adjuvant therapies is great. Thus, our central overriding scientific focus is to discover and validate immunoregulatory targets with the potential t…
The overall response rate (ORR) in patients treated with immune checkpoints varies greatly and ranges from 30% (Head and Neck cancer) to as high as 60% as a first line therapy in malignant melanoma. Non-small cell lung cancer (NSCLC) patients treated with checkpoint inhibition therapy is up to 45% as first line therapy. The elucidation of the factors responsible for treatment failure is f…
Retrotransposable or Mobile Elements (MEs) comprise a constant threat to host genome due to their spontaneous mutational capabilities in DNA. To ensure such a level of propagation, a family of nucleic acid-modifying enzymes acts to mobilize the deleterious effects of the MEs. However, what could be regarded as a mechanism of protection to the integrity of the genome may be a source of chr…
Race refers to a population with common genetic and phenotypic features that separate them from other populations. Population studies suggest biological differences between races, in multiple aspects, such as: mutations, obesity, chronic inflammation and immune system, being, therefore, a relevant factor to be considered in the emergence and progression of diseases. Melanoma and non-small…
The human microbiome is the group established between the interactions of body sites and the microbes communities that reside within. With the advances in molecular technologies, the existence of a great microorganisms diversity that wasn't detected before was revealed. Thus, new evidence of the role of microorganisms in host health was emerging. The study of the interaction between micro…
Gastric Adenocarcinomas (GAs) are highly aggressive neoplasms with a high incidence in Brazil. The highest world rates of GA's mortality are due to few clinical signs of the disease in its early stages, which leads to late detection in most cases. Because of strong genetic and environmental component in GA etiology, the search for the causing somatic mutations processes that contribute …
| 3 / 3 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 4 / 3 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
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