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Fundação Antonio Prudente (FAP). A C Camargo Cancer Center (Institutional affiliation from the last research proposal) Birthplace: Brazil
Israel Tojal da Silva in research grants and scholarships supported by FAPESP.
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Background: Somatic hypermutation (SHM) of immunoglobulin variable (V) regions in B cells is the molecular basis for the diversification of antibodies in response to pathogens and vaccines and, therefore, for robust long-term humoral immunity. Mutations are generated by activation-induced cytidine deaminase (AID) which converts cytosines to uracils preferentially at WRCH motifs (where W =…
Immune based therapeutics such as checkpoint inhibitors have proven to work across several cancer types and the potential impact novel immuno-oncology targets can have on inducing anti-cancer responses, either as standalone, or as combination/adjuvant therapies is great. Thus, our central overriding scientific focus is to discover and validate immunoregulatory targets with the potential t…
The use of molecular biomarkers has great potential to drive precision oncology. Although promising, they are not yet widely available in the clinical routine of most medical centers and their high cost can make them unaffordable for most patients. Thus, the development of new fast and low-cost approaches becomes increasingly necessary. In this context, the use of modern techniques of Art…
INCiTO-INOTE will continue to support the scientific program previously created by the INCiTO, exploring bench-to-bedside-to-bench concepts, in order to face the challenges that are still limiting cancer prevention, diagnosis and treatment. The Institute will explore its large experience in genetics, epigenetics “comics”, bioinformatics and biomarkers to focus in areas where it can be wor…
Retrotransposable or Mobile Elements (MEs) comprise a constant threat to host genome due to their spontaneous mutational capabilities in DNA. To ensure such a level of propagation, a family of nucleic acid-modifying enzymes acts to mobilize the deleterious effects of the MEs. However, what could be regarded as a mechanism of protection to the integrity of the genome may be a source of chr…
Surgical site infection, reoperation, and readmission reflect the clinical deterioration of the patient and are indicators that measure the quality of care. In patients diagnosed with tumors in the upper airways (TVAS), clinical deterioration represents a significant burden in the oncological journey. Therefore, early detection will allow timely interventions and provide better outcomes f…
Race refers to a population with common genetic and phenotypic features that separate them from other populations. Population studies suggest biological differences between races, in multiple aspects, such as: mutations, obesity, chronic inflammation and immune system, being, therefore, a relevant factor to be considered in the emergence and progression of diseases. Melanoma and non-small…
The human microbiome is the group established between the interactions of body sites and the microbes communities that reside within. With the advances in molecular technologies, the existence of a great microorganisms diversity that wasn't detected before was revealed. Thus, new evidence of the role of microorganisms in host health was emerging. The study of the interaction between micro…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 11 / 10 | All research grants and scholarships |
| Associated processes | |