Ronaldo Aloise Pilli
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Professor Pilli holds BSc (1976) and PhD (1981)degrees from University of Campinas and post-doctoral training at University of California, Berkeley (1982-84). He has been visiting professor at Georg-August Universitat, Gottingen, Germany (1994) and at Warwick University, UK (2005). He is currently professor of Chemistry at University of Campinas working on synthetic chemistry, particularly organic synthesis of natural products and natural product-inspired compounds for biological studies. He has also several patents applications on the synthesis of pharmaceutical active ingredients such as methyl phenidate, tamoxifen, levobupivacine and fluoxetine. He has served the Brazilian Chemical Society as secretary of the division of Organic Chemistry and on the editorial board of Quimica Nova and the Journal of the Brazilian Chemical Society and as head of the Institute of Chemistry and Vice-chancellor for Research at University of Campinas. Professor Pilli has received the Union Carbide Award (1989), the Silver Jubilee Award from the International Foundation for Science, Sweden (1999), the National Medal for Scientific Achievement (2006), the Zeferino Vaz Award from the University of Campinas (2008), the Simão Mathias Award from the Brazilian Chemical Society (2012) and is a member of the São Paulo Science Academy (2012). He has been involved with outreach programs (Chemistry in Action, Science&Arts Program and Brazilian Chemistry Olympiad) and is currently the head of the outreach program of the "Multidisciplinary Center for Obesity and Related Diseases" funded by FAPESP. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Brazil must strengthen medicinal chemistry to achieve progress in drug discovery |
- Planning and synthesis of inhibitors based on biological targets: the case of neglected kinases, AP.R
Abstract
This research proposal deals with the synthesis of heterocyclic compounds to be investigated as chemical probes and inhibitors of the neglected kinases LOK/STK10, VRK1 and VRK2 as well as the synthesis of brazilin and its analogues in order to probe their cytotoxic activities against cancer cell lines both in the non-encapsulated and associated with AcDex nanoparticles. The structures o...
- Protein Kinase Chemical Biology Center: supporting drug development through open-access research, AP.PITE
Abstract
Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas...
- OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Abstract
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected...
- A biomimetic approach to the total synthesis of Stemona alkaloids, AP.R
Abstract
The total synthesis of representatives of the Stemona alkaloids is proposed based on a biossynthetic rationale. Our synthetic efforts will be directed to the synthesis of racemic tuberostemospironine, stemolactam R, tuberostemospiroline, croomine and sessilifoliamide J. Our approach is based on the intramolecular tandem vinylogous Mannich cyclization reaction of a silyloxyfuran and an i...
- Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM
Abstract
This research proposal aims the preparation and unambiguous structural characterization of about 100 natural and synthetic organic compounds belonging to the δ-lactone and δ-lactam families (mostly, α, β-unsaturated ones), butenolide diterpenes, 1,4-quinones of the caulibugulone family and (β-hydroxy-α-methylenic esters together with their biological evaluation against: i) a panel of ni...
- International workshop on nanomaterials and functional materials, AO.R
(Only some records are available in English at this moment)
- Organocatalytic approaches to the enantioselective synthesis of Stemona alkaloids, BP.PD
Abstract
We aim to investigate organocatalyzed approaches to the asymmetric synthesis of alkaloids isolated from herbal extracts of plants of the Stemonaceae family which have been employed in the asian folk medicine. We plan to develop methodologies for the enantioselective synthesis of alkaloids from the stemoamide, tuberostemospironine and parvistemoline groups based on the chemistry of cyc...
- Development of nanocarriers based on dendrimers and polymer nanoparticles for selective delivery of goniothalamin, piplartine and Monastrol, BP.PD
Abstract
Biodegradable and biocompatible dendrimers and acetalated dextran (Ac-DEX) polymeric nanoparticles hold great promise as nanocarriers for the delivery of bioactivecompounds for anticancer therapy. The advantages of using these nanomaterials as drug delivery systems include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific ...
- Synthesis of glibenclamide new derivatives in order to obtain potential antihyperglycemic drugs, BP.PD
Abstract
The research proposal aims to prepare a small library of analogues of Glibenclamide in order to be in vivo evaluated as anti-hyperglicemic agents. Analogues containing the piperazine moiety as a spacer between the amide and phenylsulfonil groups of Glibenclamide will be prepared. The use of flow chemistry methodology will be considered for scaling up the synthesis. (AU)
- Total synthesis of CRYPTOPYRANMOSCATONES B2 and B4, BP.PD
Abstract
This project has as its main objective the structural elucidation of the natural products Cryptopyranmoscatones B2 and B4 isolated from the Brazilian biodiversity. The synthetic route involves asymmetric Mukaiyama aldol reactions, Krische allylation, cross metathesis and cyclization using the Tsuji-Trost reaction as key steps. We also aim the evaluation of the antineoplastic activity of...
(Only some records are available in English at this moment)
- Polynorbornene-Goniothalamin and Polynorbornene-Piplartine conjugates for cancer therapy, BE.EP.PD
Abstract
Natural products have been the major source of inspiration for the development of novel drugs for cancer treatments. In particular, several studies have highlighted the potential of goniothalamin (GTN) and piplartine (PPT), natural products found in plants, for cancer therapy. However, their low water solubility, and significant toxicity towards healthy cells can severely limit their ap...
- Total Synthesis of Eremantholide A and C, BE.EP.PD
Abstract
In connection with our interests in the total synthesis of brazilian natural products, this project aims the total synthesis of (+)-Eremantholide A and the first total synthesis of (-)-Eremantholide C. Our novel asymmetric route to both complex natural products is based on a biomimetic approach, starting from a germacrane-type sesquiterpene already reported, which is derived from commer...
- Synthesis and structural validation of phosdiecin a, BE.EP.DD
Abstract
The research deals with the total syntheses of phosdiecin A, a polyketide isolated from from a culture of the marine Streptomyces sp. SS99BA-2 collected in São Sebastião Channel, Brazil. The interest to unravel the true identity of this molecule by total synthesis in collaboration with Prof. Krische from the University of Texas at Austin through catalytic asymmetric carbonyl addition me...
- Synthesis of Dihydrocoumarins-C-Aryl glucosides as potential SGLT2 inhibitors using asymmetric Photoredox catalysis, BE.EP.PD
Abstract
This project is about the synthesis of novel di-hydrocoumarin-C-aryl glucosides as potential anti-hyperglycemic agents for the treatment of type 2 diabetes. Such compounds can be synthesized by means of a asymmetric photochemical beta-arylation of Michael acceptors, using chiral Lewis acids. If this methodology does not provide the desired compounds, a secondary approach is the use of t...
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 16 / 11 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 63 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 92 / 42 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 47 |
| Citations | 874 |
| Cit./Article | 18.6 |
| Data from Web of Science | |
DE ASSIS, FRANCISCO F.; HUANG, XIAOQIANG; AKIYAMA, MIDORI; PILLI, RONALDO A.; MEGGERS, ERIC. Visible-Light-Activated Catalytic Enantioselective beta-Alkylation of alpha, beta-Unsaturated 2-Acyl Imidazoles Using Hantzsch Esters as Radical Reservoirs. Journal of Organic Chemistry, v. 83, n. 18, p. 10922-10932, SEP 21 2018. Web of Science Citations: 0. (13/07607-8, 17/06836-4)
HUANG, XIAOQIANG; AKIYAMA, MIDORI; MEGGERS, ERIC. . Journal of Organic Chemistry, v. 83, n. 18, p. 10922-10932, SEP 21 2018. Web of Science Citations: 0. (13/07607-8, 17/06836-4)
DELLA-FELICE, FRANCO; PILLI, RONALDO A.; SAROTTI, ARIEL M.. Computer-Guided Total Synthesis of Natural Products. Recent Examples and Future Perspectives. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 1041-1075, MAY 2018. Web of Science Citations: 1. (13/07607-8, 16/12541-4, 14/25474-8)
OLIVEIRA, F. L.; HUBER, P. C.; ALMEIDA, W. P.; SABINO, J. R.; APARICIO, R.. Tris[2-(1,3-thiazol-2-yl-kappa N)-1H-benzimidazole-kappa N-3]zinc(II) dinitrate ethanol hemisolvate monohydrate at 100 K. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, v. 69, n. 2, p. 119+, FEB 2013. Web of Science Citations: 0. (10/20861-2, 09/51602-5)
NACIUK, FABRICIO F.; MILAN, JULIO C.; ANDREAO, ALMIR; MIRANDA, PAULO C. M. L.. Exploitation of a Tuned Oxidation with N-Haloimides in the Synthesis of Caulibugulones A-D. Journal of Organic Chemistry, v. 78, n. 10, p. 5026-5030, MAY 17 2013. Web of Science Citations: 7. (09/51602-5)
CARNEIRO, VANIA M. T.; AVILA, CAROLINA M.; BALUNAS, MARCY J.; GERWICK, WILLIAM H.; PILLI, RONALDO A.. Coibacins A and B: Total Synthesis and Stereochemical Revision. Journal of Organic Chemistry, v. 79, n. 2, p. 630-642, JAN 17 2014. Web of Science Citations: 17. (10/08673-6, 09/51602-5, 11/00457-5)
PASTRE, JULIO C.; BROWNE, DUNCAN L.; O'BRIEN, MATTHEW; LEY, STEVEN V.. Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia. ORGANIC PROCESS RESEARCH & DEVELOPMENT, v. 17, n. 9, p. 1183-1191, SEP 2013. Web of Science Citations: 46. (12/05909-4)
MURRAY, PHILIP R. D.; BROWNE, DUNCAN L.; PASTRE, JULIO C.; BUTTERS, CHRIS; GUTHRIE, DUNCAN; LEY, STEVEN V.. Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen. ORGANIC PROCESS RESEARCH & DEVELOPMENT, v. 17, n. 9, p. 1192-1208, SEP 2013. Web of Science Citations: 81. (12/05909-4)
NEWBY, JAMES A.; BLAYLOCK, D. WAYNE; WITT, PAUL M.; PASTRE, JULIO C.; ZACHAROVA, MARIJA K.; LEY, STEVEN V.; BROWNE, DUNCAN L.. Design and Application of a Low-Temperature Continuous Flow Chemistry Platform. ORGANIC PROCESS RESEARCH & DEVELOPMENT, v. 18, n. 10, p. 1211-1220, OCT 2014. Web of Science Citations: 25. (12/05909-4)
TONETO NOVAES, LUIZ FERNANDO; AVILA, CAROLINA MARTINS; PELIZZARO-ROCHA, KARIN JULIANE; VENDRAMINI-COSTA, DEBORA BARBOSA; DIAS, MARINA PEREIRA; BARBOSA TRIVELLA, DANIELA BARRETO; DE CARVALHO, JOAO ERNESTO; FERREIRA-HALDER, CARMEN VERISSIMA; PILLI, RONALDO ALOISE. (-)-Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies. CHEMMEDCHEM, v. 10, n. 10, p. 1687-1699, OCT 2015. Web of Science Citations: 5. (10/08673-6, 09/51602-5, 12/09254-2, 12/24385-6, 13/08896-3, 10/17544-5)
BARCELOS, ROSIMEIRE COURA; PELIZZARO-ROCHA, KARIN JULIANE; PASTRE, JULIO CEZAR; DIAS, MARINA PEREIRA; FERREIRA-HALDER, CARMEN VERISSIMA; ALOISE PILLI, RONA IDO. A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 87, p. 745-758, NOV 24 2014. Web of Science Citations: 12. (12/24385-6, 10/16990-1, 09/51602-5, 10/15496-3)
DE SOUZA, GABRIELA F. P.; NOVAES, LUIZ F. T.; AVILA, CAROLINA M.; NASCIMENTO, LUCAS F. R.; VELLOSO, LICIO A.; PILLI, RONALDO A.. (-)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus. Molecules, v. 20, n. 3, p. 5038-5049, 2015. Web of Science Citations: 2. (13/07607-8, 12/09254-2, 10/08673-6)
TONETO NOVAES, LUIZ FERNANDO; DREKENER, ROBERTA LOPES; AVILA, CAROLINA MARTINS; PILLI, RONALDO ALOISE. Total synthesis of cryptomoscatones D1 and D2: stereochemical assignment of cryptomoscatone D1. Tetrahedron, v. 70, n. 37, p. 6467-6473, SEP 16 2014. Web of Science Citations: 18. (09/51602-5)
MARTINS, LUCIMARA J.; FERREIRA, BRUNO R. V.; ALMEIDA, WANDA P.; LANCELLOTTI, MARCELO; COELHO, FERNANDO. An easy access to halogenated and non-halogenated spiro-hexadienones. Tetrahedron Letters, v. 55, n. 38, p. 5264-5267, SEP 17 2014. Web of Science Citations: 7. (11/20033-5, 09/18390-4, 09/51602-5)
PASTRE, JULIO C.; BROWNE, DUNCAN L.; LEY, STEVEN V.. Flow chemistry syntheses of natural products. CHEMICAL SOCIETY REVIEWS, v. 42, n. 23, p. 8849-8869, 2013. Web of Science Citations: 368. (12/05909-4)
BARCELOS, ROSIMEIRE COURA; PASTRE, JULIO CEZAR; CAIXETA, VANESSA; VENDRAMINI-COSTA, DEBORA BARBOSA; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE. Synthesis of methoxylated goniothalamin, aza-goniothalamin and gamma-pyrones and their in vitro evaluation against human cancer cells. Bioorganic & Medicinal Chemistry, v. 20, n. 11, p. 3635-3651, JUN 1 2012. Web of Science Citations: 27. (10/16990-1, 09/51602-5)
VENDRAMINI-COSTA, DEBORA BARBOSA; DALTRO DE CASTRO, ILTON BARROS; TASCA GOIS RUIZ, ANA LUCIA; MARQUISSOLO, CILENE; PILLI, RONALDO ALOISE; DE CARVALHO, JOAO ERNESTO. Effect of goniothalamin on the development of Ehrlich solid tumor in mice. Bioorganic & Medicinal Chemistry, v. 18, n. 18, p. 6742-6747, SEP 15 2010. Web of Science Citations: 41. (09/51602-5)
DE FÁTIMA‚ Â.; KOHN‚ L.K.; DE CARVALHO‚ J.E.; PILLI‚ R.A.. Cytotoxic activity of ( S)-goniothalamin and analogues against human cancer cells. Bioorganic & Medicinal Chemistry, v. 14, n. 3, p. 622-631, 2006.
HUANG, XIAOQIANG. . Journal of Organic Chemistry, v. 83, n. 18, p. 10922-10932, SEP 21 2018. Web of Science Citations: 8. (13/07607-8, 17/06836-4)
WANG, JIE; SHANG, MING; LUNDBERG, HELENA; FEU, KARLA S.; HECKER, SCOTT J.; QIN, TIAN; BLACKMOND, DONNA G.; BARAN, PHIL S.. Cu-Catalyzed Decarboxylative Borylation. ACS CATALYSIS, v. 8, n. 10, p. 9537-9542, OCT 2018. Web of Science Citations: 23. (17/08128-7)
MEIRELLES, MATHEUS A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; PILLI, RONALDO A.. Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells. CHEMMEDCHEM, v. 14, n. 15, JULY 2019. Web of Science Citations: 0. (13/07607-8, 18/02093-0, 17/06146-8)
DELLA-FELICE, FRANCO; SAROTTI, ARIEL M.; KRISCHE, MICHAEL J.; PILLI, RONALDO A.. Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling. Journal of the American Chemical Society, v. 141, n. 35, p. 13778-13782, SEP 4 2019. Web of Science Citations: 0. (13/07607-8, 17/18487-4, 14/25474-8, 16/12541-4)
SHANG, MING; FEU, KARLA S.; VANTOUROUT, JULIEN C.; BARTON, LISA M.; OSSWALD, HEATHER L.; KATO, NOBUTAKA; GAGARING, KERSTIN; MCNAMARA, CASE W.; CHEN, GANG; HU, LIANG; et al. Modular, stereocontrolled C-beta-H/C-alpha-C activation of alkyl carboxylic acids. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, n. 18, p. 8721-8727, APR 30 2019. Web of Science Citations: 1. (17/08128-7)
BRAGA, CAROLYNE B.; PERLI, GABRIEL; BECHER, TIAGO B.; OMELAS, CATIA. Biodegradable and pH-Responsive Acetalated Dextran (Ac-Dex) Nanoparticles for NIR Imaging and Controlled Delivery of a Platinum-Based Prodrug into Cancer Cells. MOLECULAR PHARMACEUTICS, v. 16, n. 5, p. 2083-2094, MAY 2019. Web of Science Citations: 0. (18/02093-0, 17/24488-3, 17/06146-8)
DELLA-FELICE, FRANCO; DE ASSIS, FRANCISCO F.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Palladium-Catalyzed Formation of Substituted Tetrahydropyrans: Mechanistic Insights and Structural Revision of Natural Products. SYNTHESIS-STUTTGART, v. 51, n. 7, p. 1545-1560, APR 2019. Web of Science Citations: 0. (13/07607-8, 16/12541-4, 14/25474-8)
VENDRAMINI-COSTA, DEBORA BARBOSA; SPINDOLA, HUMBERTO MOREIRA; DE MELLO, GLAUCIA COELHO; ANTUNES, EDSON; PILLI, RONALDO ALOISE; DE CARVALHO, JOAO ERNESTO. Anti-inflammatory and antinociceptive effects of racemic goniothalamin, a styryl lactone. Life Sciences, v. 139, p. 83-90, OCT 15 2015. Web of Science Citations: 16. (12/18281-3, 09/51602-5)
VENDRAMINI-COSTA, DEBORA BARBOSA; MONTEIRO, KARIN MAIA; IWAMOTO, LEILANE HESPPORTE; JORGE, MICHELLE PEDROZA; TINTI, SIRLENE VALERIO; PILLI, RONALDO ALOISE; DE CARVALHO, JOAO ERNESTO. Gastroprotective effects of goniothalamin against ethanol and indomethacin-induced gastric lesions in rats: Role of prostaglandins, nitric oxide and sulfhydryl compounds. Chemico-Biological Interactions, v. 224, p. 206-212, DEC 5 2014. Web of Science Citations: 13. (12/18281-3, 09/51602-5)
PILLI, RONALDO A.; DE ASSIS, FRANCISCO F.. Organic Synthesis: New Vistas in the Brazilian Landscape. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 895-941, 2018. Web of Science Citations: 0. (13/07607-8, 16/12541-4, 16/08569-0, 17/06836-4)
NOVAES, LUIZ F. T.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies. Journal of Organic Chemistry, v. 80, n. 24, p. 12027-12037, DEC 18 2015. Web of Science Citations: 22. (13/07607-8, 09/51602-5)
-FELICE, FRANCO DELLA; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Catalytic Asymmetric Synthesis and Stereochemical Revision of (+)-Cryptoconcatone H. Journal of Organic Chemistry, v. 82, n. 17, p. 9191-9197, SEP 1 2017. Web of Science Citations: 7. (13/07607-8, 16/12541-4, 14/25474-8)
VIVAS, M. G.; GERMINO, J. C.; BARBOZA, C. A.; SIMON, DEBORAH DE A.; VAZQUEZ, P. A. M.; DE BONI, L.; ATVARS, T. D. Z.; MENDONCA, C. R.. Revealing the Dynamic of Excited State Proton Transfer of a pi-Conjugated Salicylidene Compound: An Experimental and Theoretical Study. Journal of Physical Chemistry C, v. 121, n. 2, p. 1283-1290, JAN 19 2017. Web of Science Citations: 8. (11/12399-0, 09/51602-5, 13/16245-2)
VENDRAMINI-COSTA, DEBORA BARBOSA; FRANCESCONE, RALPH; POSOCCO, DAVID; HOU, VIVIANTY; DMITRIEVA, OXANA; HENSLEY, HARVEY; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE; GRIVENNIKOV, SERGEI I.. Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis. Carcinogenesis, v. 38, n. 1, p. 51-63, JAN 2017. Web of Science Citations: 12. (14/05189-7, 09/51602-5)
BRITO, GILMAR A.; PIROVANI, RODRIGO V.. Stemoamide: Total and Formal Synthesis. A Review. ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, v. 50, n. 3, p. 245-259, 2018. Web of Science Citations: 4. (12/23569-6, 10/00219-4)
FERNANDES, DANIARA C.; SIMONI, DEBORAH DE ALENCAR; RODRIGUES, JR., MANUEL T.; SANTOS, MARILIA S.; COELHO, FERNANDO. Crystal structure of 3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydrocyclopenta[b]indole-2-car boxylic acid. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 71, n. 6, p. O395-U248, JUN 2015. Web of Science Citations: 1. (13/07600-3, 09/51602-5)
FONSECA, EMANUELLA M. B.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; DIAS, MARIANA P.; BAZZO, NATALIA L.; MANDAPATI, KISHORE R.; DE OLIVEIRA, FABIO L.; FERREIRA-HALDER, CARMEN V.; PILLI, RONALDO A.; MIRANDA, PAULO C. M. L.; et al. Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorganic & Medicinal Chemistry, v. 23, n. 15, p. 4462-4471, AUG 1 2015. Web of Science Citations: 4. (11/03054-9, 11/15792-4, 09/51602-5, 10/17544-5)
RAITZ, ISMAEL; DE SOUZA FILHO, ROBERTO Y.; DE ANDRADE, LORENA P.; CORREA, JOSE R.; NETO, BRENNO A. D.; PILLI, RONALDO A.. Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative. ACS OMEGA, v. 2, n. 7, p. 3774-3784, JUL 2017. Web of Science Citations: 2. (13/07607-8, 16/12541-4, 09/51602-5)
BRITO, GILMAR A.; DELLA-FELICE, FRANCO; LUO, GUOSHUN; BURNS, ALEXANDER S.; PILLI, RONALDO A.; RYCHNOVSKY, SCOTT D.; KRISCHE, MICHAEL J.. Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling. ORGANIC LETTERS, v. 20, n. 13, p. 4144-4147, JUL 6 2018. Web of Science Citations: 2. (17/18487-4, 17/00734-5)
LUNA-FREIRE, KRISTERSON R.; SCARAMAL, JOAO PAULO S.; RESENDE, JACKSON A. L. C.; TORMENA, CLAUDIO F.; OLIVEIRA, FABIO L.; APARICIO, RICARDO; COELHO, FERNANDO. An asymmetric substrate-controlled Morita-Baylis-Hillman reaction as approach for the synthesis of pyrrolizidinones and pyrrolizidines. Tetrahedron, v. 70, n. 20, p. 3319-3326, MAY 20 2014. Web of Science Citations: 5. (11/20033-5, 09/51602-5)
BRUDER, MARJORIE; VENDRAMINI-COSTA, DEBORA BARBOSA; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE. Design, synthesis and in vitro evaluation against human cancer cells of 5-methyl-5-styryl-2,5-dihydrofuran-2-ones, a new series of goniothalamin analogues. Bioorganic & Medicinal Chemistry, v. 21, n. 17, p. 5107-5117, SEP 1 2013. Web of Science Citations: 17. (09/51602-5)
LIRA, LUCAS M.; VASILEV, DIMITAR; PILLI, RONALDO A.; WESSJOHANN, LUDGER A.. One-pot synthesis of organophosphate monoesters from alcohols. Tetrahedron Letters, v. 54, n. 13, p. 1690-1692, MAR 27 2013. Web of Science Citations: 13. (09/51602-5)
NOVAES, LUIZ F. T.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Total synthesis and stereochemical assignment of cryptolatifolione. RSC ADVANCES, v. 5, n. 66, p. 53471-53476, 2015. Web of Science Citations: 7. (09/51602-5)
CARNEIRO, VANIA M. T.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; BERALDO, VIVIANE L.; DIAS, MARIANA P.; SOBREIRA, TIAGO J. P.; APARICIO, RICARDO; PILLI, RONALDO A.. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 97, p. 42-54, JUN 5 2015. Web of Science Citations: 4. (13/07607-8, 11/00457-5, 09/51602-5, 10/17544-5)
PIROVANI, RODRIGO V.; BRITO, GILMAR A.; BARCELOS, ROSIMEIRE C.; PILLI, RONALDO A.. Enantioselective Total Synthesis of (+)-Lyngbyabellin M. MARINE DRUGS, v. 13, n. 6, p. 3309-3324, JUN 2015. Web of Science Citations: 6. (13/07607-8, 10/00219-4, 09/51602-5, 10/00336-0)
BARCELOS, ROSIMEIRE COURA; PASTRE, JULIO CEZAR; VENDRAMINI-COSTA, DEBORA BARBOSA; CAIXETA, VANESSA; LONGATO, GIOVANNA BARBARINI; MONTEIRO, PAULA ARAUJO; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE. Design and Synthesis of N-Acylated Aza-Goniothalamin Derivatives and Evaluation of Their in vitro and in vivo Antitumor Activity. CHEMMEDCHEM, v. 9, n. 12, p. 2725-2743, DEC 2014. Web of Science Citations: 17. (10/16990-1, 12/18281-3, 09/51602-5)
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