Abstract
Hereditary angioedema (HAE) is a rare disease with autosomal dominant inheritance, characterized by recurrent attacks of subcutaneous edema of upper airways and gastrointestinal tract. In its classic form, the HAE is caused by mutations in SERPING1 gene encoding the C1 inhibitor (C1-INH). HAE Type I results from the quantitative deficiency of C1-INH, whereas HAE type II is characterized b…