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Filmes nanoestruturados de materiais de interesse biológico

Processo: 13/14262-7
Modalidade de apoio:Auxílio à Pesquisa - Temático
Data de Início da vigência: 01 de maio de 2014
Data de Término da vigência: 30 de abril de 2019
Área do conhecimento:Ciências Exatas e da Terra - Física - Física da Matéria Condensada
Pesquisador responsável:Osvaldo Novais de Oliveira Junior
Beneficiário:Osvaldo Novais de Oliveira Junior
Instituição Sede: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brasil
Pesquisadores principais:
Carlos José Leopoldo Constantino ; Debora Goncalves ; Debora Terezia Balogh ; Frank Nelson Crespilho
Pesquisadores associados:Felippe José Pavinatto ; Luciano Caseli ; Priscila Alessio Constantino
Auxílio(s) vinculado(s):18/17697-8 - 2018 MRS Fall Meetings & Exhibits, AR.EXT
17/03596-2 - Simulação de efeitos plasmônicos para sensoriamento, AV.EXT
17/04542-3 - Interação do triclosan com filmes de Langmuir como modelo de membrana celular, AV.EXT
 + mais auxílios vinculados 17/03879-4 - EMU concedido no projeto temático 2013/14262-7 - DLS, AP.EMU
16/12807-4 - Camadas de polímero com incorporação de nanopartículas metálicas: plataforma para construção de bio(sensores), AV.EXT
14/11410-8 - EMU concedido no processo 2013/14262-7: Streamline Renishaw, AP.EMU
14/12557-2 - EMU concedido no processo 2013/14262-7; reômetro interfacial, AP.EMU
14/11408-3 - EMU concedido no processo 2013/14262-7: microscópio confocal, AP.EMU
14/11407-7 - EMU concedido no projeto 2013/14262-7: elipsômetro espectrográfico com acessórios, AP.EMU
14/12556-6 - EMU concedido no processo 2013/14262-7: microscópio de imageamento por infravermelho, AP.EMU
14/25784-7 - Estratégias para a N-glicosilação de alcaloides de indocarbazol e sua interação com modelos de membrana, AV.EXT - menos auxílios vinculados
Bolsa(s) vinculada(s):19/04407-4 - Estudo da atividade superficial de lactonas alquiladas e sua interação em modelos de membrana celular, BP.IC
18/22091-1 - Filmes de langmuir e langmuir-blodgett de lipídios contendo pectinase para sensores de pectina, BP.MS
18/25943-9 - Estudo da interação de nitrofurantoína em modelos de membrana celular através de filmes de Langmuir, BP.IC
 + mais bolsas vinculadas 18/00878-0 - Estudo de jangadas lipídicas com a interação entre modelos de membrana e quitosana e colesterol oxidase, BP.PD
18/00291-9 - Filmes de Langmuir e Langmuir-Blodgett de lipídios contendo fenilalanina desidrogenase para sensores de fenilalanina, BP.MS
18/02898-8 - Bisfenol-A como poluente emergente: estudo de seus efeitos em modelos de membrana com diferentes composições, BP.IC
17/25587-5 - Projeto numérico de pinças ópticas nanofotônicas totalmente dielétricas para manipulação sem perdas de pequenas nanopartículas, BP.DR
18/01984-8 - Efeito do inseticida acefato em modelos simples de membranas lipídicas baseados em Filmes de Langmuir e GUVs: interação em nível molecular e efeitos morfológicos, BP.MS
18/03044-2 - Método gel polimérico aplicado na formação de vesículas unilamelares gigantes, BP.IC
17/20493-2 - Estudo de metaloenzimas por eletroquímica acoplada à espectroscopia vibracional, BP.DR
17/22186-0 - Efeito e formato de nanoparticulas metálicas na sua interação com biomoléculas e/ou vesículas gigantes de fosfolipidios, BP.PD
17/15605-6 - Imunossensor flexível para detecção de cortisol em amostras não-invasivas de saliva, BP.IC
17/16563-5 - Amoxicilina como poluente emergente: seus efeitos em modelos de membrana com diferentes composições, BP.IC
17/15219-9 - Estudos de Raman amplificado em superfície (SERS) de biomoléculas, BP.IC
17/12096-3 - Fabricação de eletrodos interdigitados impressos para biossensores para detecção de biomarcadores de câncer, BP.IC
17/03503-4 - Interação molecular entre quitosanas e modelos de membrana celular investigada por espectroscopia vibracional não linear, BP.PD
16/24366-2 - Sensores fotoeletroquímicos e eletroquímicos a base de pontos quânticos para detectar gases tóxicos e biomarcadores, BP.PD
16/24694-0 - Desenvolvimento de uma plataforma universal para a fabricação de transistores eletroquímicos orgânicos e sua aplicação em biossensores, BP.MS
17/04712-6 - Estudo das interações do fármaco cloridrato de gencitabina com modelos de membranas lipídicas, BP.IC
16/25806-6 - Interação entre biomoléculas e nanoestruturas: eletroquímica, interfaces e superfícies, BP.PD
16/23619-4 - Miniaturização de línguas eletrônicas baseadas em técnicas eletroquímicas, BP.IC
16/23665-6 - Otimização do sistema de controle de dispositivos miniaturizados de medição múltipla de espectroscopia de impedância, BP.IC
16/09634-0 - Interação entre modelos de biomembrana baseados em filmes de Langmuir e vesículas unilamelares gigantes (GUVs) com herbicidas triazínicos e detecção via espectroscopia SERS., BP.DR
16/09633-4 - Mecanismo de ação do composto bioativo Artepillin C em sistemas miméticos de membranas e membranas citoplasmáticas de células tumorais, BP.PD
16/12311-9 - Efeito transversal magneto-óptico Kerr para o desenho e desenvolvimento de biosessores, BP.PD
16/06424-5 - Eletroformação de vesículas unilamelares gigantes aplicadas como sistemas miméticos de biomembranas, BP.PD
16/09358-3 - Miniaturização de línguas eletrônicas baseadas em espectroscopia de impedância, BP.IC
16/06612-6 - Biossensor impresso e implantável fabricado com biopolímeros para monitoramento de longa duração, BP.PD
15/16857-3 - Uso de modelos de membrana para estudar o mecanismo de ação de peptídeos antimicrobianos e efeitos da dimerização e ciclização, BP.PD
15/16604-8 - Automação da aquisição de dados de impedância em sensores e biossensores, BP.IC
15/10751-9 - Interação entre o pesticida carbendazim e sistemas-modelo simples de membrana biológica baseados em filmes de Langmuir e GUVs: o papel desempenhado pela insaturação da cadeia hidrofóbica, BP.IC
15/01770-0 - Desenvolvimento de instrumentos analíticos baseados em línguas eletrônicas para detecção simultânea de ameaças bacterianas, BP.PD
14/17260-8 - Foto-oxidação lipídica em membranas biomiméticas: de efeitos moleculares a impacto em fotomedicina, BP.PD
14/12567-8 - Estruturas peptídicas auto-organizadas: preparação, caracterização e interação com sistemas modelos de membrana, BP.PD
14/15100-3 - Filmes finos nanoestruturados para aplicação em sensores de polifenóis, BP.IC
14/03748-9 - Peptídeos antimicrobianos cíclicos: importância da estrutura cíclica no mecanismo de ação de duas diferentes estruturas., BP.PD
13/04246-4 - Imobilização da dapsona em sistemas biomiméticos: filmes automontados e monocamadas de Langmuir e Langmuir-Blodgett, BP.PD
12/15543-7 - Biossensores para detectar Escherichia coli usando o conceito de línguas eletrônicas, BP.PD - menos bolsas vinculadas
Assunto(s):Técnicas biossensoriais  Filmes finos  Filmes ultrafinos  Filmes Langmuir-Blodgett  Técnica de automontagem  Nanotecnologia  Espectroscopia Raman 
Palavra(s)-Chave do Pesquisador:biossensores | espectroscopia Raman | filmes automontados por adsorção física | Filmes Langmuir-Blodgett | filmes nanoestruturados | modelos de membrana celular | Filmes Finos e Ultrafinos - Langmuir-Blodgett e LbL

Resumo

Este projeto integrará quatro grupos de diferentes instituições para investigar filmes nanoestruturados de interesse biológico, com ênfase em três tópicos: i) uso de filmes de Langmuir, Langmuir-Blodgett (LB) e vesículas como modelos de membranas celulares, ii) biossensores e iii) detecção de moléculas isoladas (SMD, single molecule detection). Os filmes serão fabricados com as técnicas LB e automontagem por adsorção física, a partir de uma variedade de materiais, e caracterizados por medidas elétricas, microscopias e espectroscopias ópticas (já disponíveis nos Grupos participantes), além de microscopia confocal, reometria de interfaces e elipsometria, com equipamentos a serem adquiridos. Com a expansão do parque de equipamentos e integração de esforços dos Grupos pretende-se abordar problemas científicos relevantes para a nanobiotecnologia. A elipsometria espectroscópica, por exemplo, permite obter parâmetros como constante dielétrica complexa, coeficiente de absorção e espessura dos diferentes tipos de filmes. Já a microscopia por FTIR acoplada à eletroquímica permitirá elucidar os mecanismos de interação entre biomoléculas e superfícies sólidas in situ, contribuindo para o design de novos biodispositivos para diagnóstico. Nos modelos de membrana, o intuito é correlacionar propriedades das moléculas de interesse biológico com suas funções fisiológicas. Para os biossensores, uma plataforma genérica baseada em filmes nanoestruturados será usada para detectar antígenos ou anticorpos em análise clínica de doenças negligenciadas e câncer. Os dados serão processados por métodos de visualização de informação e reconhecimento de padrões. Em SMD, será empregada a espectroscopia de espalhamento Raman amplificado em superfície (SERS) visando à detecção de moléculas de interesse biológico. Em todos os problemas abordados, buscar-se-á sinergia entre os Grupos de pesquisa. (AU)

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Publicações científicas (194)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
ESTEVAM-ALVES, REGINA; DIAS FERREIRA, PAULO HENRIQUE; COATRINI, ANDREY C.; OLIVEIRA, JR., OSVALDO N.; FONTANA, CARLA RAQUEL; MENDONCA, CLEBER RENATO. Femtosecond Laser Patterning of the Biopolymer Chitosan for Biofilm Formation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 17, n. 8, . (11/12399-0, 16/05345-4, 13/14262-7)
MEJIA-SALAZAR, JORGE R.; CAMACHO, SABRINA A.; CONSTANTINO, CARLOS J. L.; OLIVEIRA JUNIOR, OSVALDO N.. New trends in plasmonic (bio)sensing. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 779-801, . (13/01897-4, 13/14262-7, 16/12311-9)
PEREIRA, ANDRESSA R.; DE SOUZA, JOAO C. P.; GONCALVES, ANDRESSA D.; PAGNONCELLI, KAMILA C.; CRESPILHO, FRANK N.. Bioelectrooxidation of Ethanol Using NAD-Dependent Alcohol Dehydrogenase on Oxidized Flexible Carbon Fiber Arrays. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 1698-1707, . (15/16672-3, 13/14262-7, 13/19908-2)
GIRON-SEDAS, J. A.; REYES GOMEZ, F.; ALBELLA, PABLO; MEJIA-SALAZAR, J. R.; OLIVEIRA, JR., OSVALDO N.. Giant enhancement of the transverse magneto-optical Kerr effect through the coupling of epsilon-near-zero and surface plasmon polariton modes. Physical Review B, v. 96, n. 7, . (13/14262-7, 16/12311-9)
GIRON-SEDAS, J. A.; MEJIA-SALAZAR, J. R.; GRANADA, J. C.; OLIVEIRA, JR., OSVALDO N.. Repulsion of polarized particles near a magneto-optical metamaterial. Physical Review B, v. 94, n. 24, . (13/14262-7, 16/12311-9)
MIYAZAKI, CELINA MASSUMI; SHIMIZU, FLAVIO MAKOTO; MEJIA-SALAZAR, J. R.; OLIVEIRA, JR., OSVALDO N.; FERREIRA, MARYSTELA. Surface plasmon resonance biosensor for enzymatic detection of small analytes. Nanotechnology, v. 28, n. 14, . (13/14262-7, 16/12311-9, 14/15093-7, 12/15543-7, 14/17519-1)
AUGUSTO SILVA, HEVELIN REGIANE; DE SOUZA, GABRIELLE MESSIAS; FERNANDES, JOSE DIEGO; LEOPOLDO CONSTANTINO, CARLOS JOSE; WINKELSTROTER, LIZZIANE KRETLI. Unravelling the effects of the food components ascorbic acid and capsaicin as a novel anti-biofilm agent against Escherichia coli. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, . (17/05989-1, 13/14262-7)
CURCINO DA SILVA, SILESIA DE FATIMA; FOSCHINI, MAURICIO; TOZONI, JOSE ROBERTO; OLIVEIRA JR, OSVALDO N.; CAMPANA, PATRICIA TARGON; MARLETTA, ALEXANDRE. Decoupling Temperature-Volume Effects on Poly[2-Methoxy-5-(2 `-Ethylhexyloxy)-1,4-Phenylene-Vinylene] Films at the beta-Relaxation Temperature. Journal of Physical Chemistry A, v. 124, n. 26, p. 5496-5501, . (13/14262-7)
ZIGLIO, ANALINE C.; SARDELA, MAURO R.; GONCALVES, DEBORA. Wettability, surface free energy and cellulose crystallinity for pine wood (Pinus sp.) modified with chili pepper extracts as natural preservatives. Cellulose, v. 25, n. 10, p. 6151-6160, . (13/14262-7, 14/02766-3)
MACEDO, LUCYANO J. A.; LIMA, FITIPE C. D. A.; AMORIM, RODRIGO G.; FREITAS, RAUL O.; YADAV, ANUR; IOST, RODRIGO M.; BALASUBRAMANIAN, KANNAN; CRESPILHO, FRANK N.. Interplay of non-uniform charge distribution on the electrochemical modification of graphene. NANOSCALE, v. 10, n. 31, p. 15048-15057, . (13/14262-7, 15/16672-3)
KHALID, MOHD.; HASSAN, AYAZ; HONORATO, ANA M. B.; CRESPILHO, FRANK N.; VARELA, HAMILTON. Nano-flocks of a bimetallic organic framework for efficient hydrogen evolution electrocatalysis. CHEMICAL COMMUNICATIONS, v. 54, n. 78, p. 11048-11051, . (13/14262-7, 13/16930-7, 15/16672-3, 16/25806-6, 17/00433-5)
HERBERT WINNISCHOFER; ELIZANGELA C. CESCA; ALEJANDRO E. P. MENDOZA; IOLANDA P. ARAÚJO; EDUARD WESTPHAL; DANIELA Z. MEZALIRA; DÉBORA T. BALOGH; OSVALDO N. OLIVEIRA JR.. Heterostructured Langmuir-Blodgett Films of Ruthenium Bipyridine with 1,3,4-Naphthooxadiazole-Derived Amphiphile Complex as a Charge Storage Electrode. Journal of the Brazilian Chemical Society, v. 31, n. 11, p. 2371-2384, . (13/14262-7)
ALI, MIAN A.; HASSAN, AYAZ; SEDENHO, GRAZIELA C.; GONCALVES, RENATO V.; CARDOSO, DANIEL R.; CRESPILHO, FRANK N.. Operando Electron Paramagnetic Resonance for Elucidating the Electron Transfer Mechanism of Coenzymes. Journal of Physical Chemistry C, v. 123, n. 26, p. 16058-16064, . (13/14262-7, 15/16672-3, 16/25806-6, 17/01189-0, 15/22973-6)
KUMAR, RAJESH; MACEDO, JR., WAGNER C.; SINGH, RAJESH K.; TIWARI, VIDHU S.; CONSTANTINO, CARLOS J. L.; MATSUDA, ATSUNORI; MOSHKALEV, STANISLAV A.. Nitrogen-Sulfur Co-Doped Reduced Graphene Oxide-Nickel Oxide Nanoparticle Composites for Electromagnetic Interference Shielding. ACS APPLIED NANO MATERIALS, v. 2, n. 7, p. 4626-4636, . (17/22186-0, 13/14262-7)
LEMMA, TIBEBE; MARQUES RUIZ, GILIA CRISTINE; OLIVEIRA, JR., OSVALDO N.; CONSTANTINO, CARLOS J. L.. The pesticide picloram affects biomembrane models made with Langmuir monolayers. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 181, p. 953-958, . (13/14262-7, 16/06424-5)
KHALID, MOHD; HASSAN, AYAZ; HONORATO, ANA M. B.; CRESPILHO, FRANK N.; VARELA, HAMILTON. 8-Hydroxyquinoline-5-sulfonic acid on reduced graphene oxide layers as a metal-free electrode material for supercapacitor applications. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 847, . (13/14262-7, 15/16672-3, 13/16930-7, 16/25806-6, 17/00433-5)
ROBSON CHACON CASTOLDI; LINCOLN JOSÉ MANGANARO; SORAIA CAROLLINE FERREIRA; MARCELO JOSÉ ALVES; CARLOS AUGUSTO DE-CARVALHO-FILHO; THIAGO ALVES GARCIA; GUILHERME AKIO TAMURA OZAKI; HELIARD RODRIGUES DOS SANTOS CAETANO; ÉVERTON ALEX CARVALHO ZANUTO; INÊS CRISTINA GIOMETTI; et al. Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 37, n. 4, p. 1416-1421, . (13/14262-7)
ANDRE, RAFAELA S.; SHIMIZU, FLAVIO M.; MIYAZAKI, CELINA M.; RIUL, JR., ANTONIO; MANZANI, DANILO; RIBEIRO, SIDNEY J. L.; OLIVEIRA, JR., OSVALDO N.; MATTOSO, LUIZ H. C.; CORREA, DANIEL S.. Hybrid layer-by-layer (LbL) films of polyaniline, graphene oxide and zinc oxide to detect ammonia. SENSORS AND ACTUATORS B-CHEMICAL, v. 238, p. 795-801, . (14/16789-5, 13/14262-7, 12/23880-3, 12/15543-7)
DELEZUKA, JORGE A. M.; PAVINATTO, ADRIANA; MORAES, MARLI L.; SHIMIZU, FLAVIO M.; RODRIGUES, VALQUIRIA C.; CAMPANA-FILHO, SERGIO P.; RIBEIRO, SIDNEY J. L.; OLIVEIRA, JR., OSVALDO N.. Silk fibroin organization induced by chitosan in layer-by-layer films: Application as a matrix in a biosensor. Carbohydrate Polymers, v. 155, p. 146-151, . (13/14262-7)
FOLLMANN, HEVELINE D. M.; OLIVEIRA, JR., OSVALDO N.; LAZARIN-BIDOIA, DANIELLE; NAKAMURA, CELSO V.; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL. Multifunctional hybrid aerogels: hyperbranched polymer-trapped mesoporous silica nanoparticles for sustained and prolonged drug release. NANOSCALE, v. 10, n. 4, p. 1704-1715, . (13/14262-7, 15/06671-0, 14/03511-9)
DE SOUZA, JOAO C. P.; IOST, RODRIGO M.; CRESPILHO, FRANK N.. Nitrated carbon nanoblisters for high-performance glucose dehydrogenase bioanodes. BIOSENSORS & BIOELECTRONICS, v. 77, p. 860-865, . (13/04663-4, 13/14262-7)
DE SOUZA, JOAO C. P.; SILVA, WANDERSON O.; LIMA, FABIO H. B.; CRESPILHO, FRANK N.. Enzyme activity evaluation by differential electrochemical mass spectrometry. CHEMICAL COMMUNICATIONS, v. 53, n. 60, p. 8400-8402, . (13/14262-7, 15/16672-3, 13/16930-7, 16/13323-0)
THAPA, ANSHU; SOARES, ANDREY COATRINI; SOARES, JULIANA COATRINI; AWAN, IRAM TAJ; VOLPATI, DIOGO; MELENDEZ, MATIAS ELISEO; GUERREIRO FREGNANI, JOSE HUMBERTO TAVARES; CARVALHO, ANDRE LOPES; OLIVEIRA, JR., OSVALDO N.. Carbon Nanotube Matrix for Highly Sensitive Biosensors To Detect Pancreatic Cancer Biomarker CA19-9. ACS APPLIED MATERIALS & INTERFACES, v. 9, n. 31, p. 25878-25886, . (13/14262-7)
WILSON, DEIVY; MATERON, ELSA M.; IBANEZ-REDIN, GISELA; FARIA, RONALDO C.; CORREA, DANIEL S.; OLIVEIRA, JR., OSVALDO N.. Electrical detection of pathogenic bacteria in food samples using information visualization methods with a sensor based on magnetic nanoparticles functionalized with antimicrobial peptides. Talanta, v. 194, p. 611-618, . (13/14262-7, 17/12174-4, 15/01770-0)
PEREIRA, TAMIRES DOS SANTOS; MAURUTO DE OLIVEIRA, GABRIELA C.; SANTOS, FABRICIO APARECIDO; RAYMUNDO-PEREIRA, PAULO A.; OLIVEIRA, JR., OSVALDO N.; JANEGITZ, BRUNO CAMPOS. Use of zein microspheres to anchor carbon black and hemoglobin in electrochemical biosensors to detect hydrogen peroxide in cosmetic products, food and biological fluids. Talanta, v. 194, p. 737-744, . (17/17572-8, 16/01919-6, 13/14262-7, 16/18270-2, 15/19099-2, 16/04743-6)
MACEDO, LUCYANO J. A.; CRESPILHO, FRANK N.. Multiplex Infrared Spectroscopy Imaging for Monitoring Spatially Resolved Redox Chemistry. Analytical Chemistry, v. 90, n. 3, p. 1487-1491, . (13/14262-7, 15/16672-3)
RAYMUNDO-PEREIRA, PAULO A.; CAMPOS, ANDERSON M.; VICENTINI, FERNANDO C.; JANEGITZ, BRUNO C.; MENDONCA, CAMILA D.; FURINI, LEONARDO N.; BOAS, NAIZA V.; CALEGARO, MARCELO L.; CONSTANTINO, CARLOS J. L.; MACHADO, SERGIO A. S.; et al. Sensitive detection of estriol hormone in creek water using a sensor platform based on carbon black and silver nanoparticles. Talanta, v. 174, p. 652-659, . (16/01919-6, 14/05197-0, 13/14262-7, 16/12759-0, 15/19099-2, 12/17689-9)
RAYMUNDO-PEREIRA, PAULO A.; CAMPOS, ANDERSON M.; MENDONCA, CAMILA D.; CALEGARO, MARCELO L.; MACHADO, SERGIO A. S.; OLIVEIRA, JR., OSVALDO N.. Printex 6L Carbon Nanoballs used in Electrochemical Sensors for Simultaneous Detection of Emerging Pollutants Hydroquinone and Paracetamol. SENSORS AND ACTUATORS B-CHEMICAL, v. 252, p. 165-174, . (16/01919-6, 14/05197-0, 13/14262-7, 16/12759-0, 12/17689-9)
FOLLMANN, HEVELINE D. M.; NAVES, ALLINY F.; ARAUJO, RAFAEL A.; DUBOVOY, VIKTOR; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL; OLIVEIRA, JR., OSVALDO N.. Hybrid Materials and Nanocomposites as Multifunctional Biomaterials. CURRENT PHARMACEUTICAL DESIGN, v. 23, n. 26, p. 3794-3813, . (13/14262-7, 15/06671-0, 14/03511-9)
PAZIN, WALLANCE MOREIRA; MARQUES RUIZ, GILIA CRISTINE; DE OLIVEIRA, JR., OSVALDO NOVAIS; LEOPOLDO CONSTANTINO, CARLOS JOSE. Interaction of Artepillin C with model membranes: Effects of pH and ionic strength. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 2, p. 410-417, . (13/14262-7, 16/09633-4)
LUZ, ROBERTO A. S.; CRESPILHO, FRANK N.. Gold nanoparticle-mediated electron transfer of cytochrome c on a self-assembled surface. RSC ADVANCES, v. 6, n. 67, p. 62585-62593, . (13/04663-4, 13/14262-7, 15/16672-3, 09/17898-4)
MENDONCA, CARLOS M. N.; BALOGH, DEBORA T.; BARBOSA, SIMONE C.; SINTRA, TANIA E.; VENTURA, SONIA P. M.; MARTINS, LUIS F. G.; MORGADO, PEDRO; FILIPE, EDUARDO J. M.; COUTINHO, JOAO A. P.; OLIVEIRA, JR., OSVALDO N.; et al. Understanding the interactions of imidazolium-based ionic liquids with cell membrane models. Physical Chemistry Chemical Physics, v. 20, n. 47, p. 29764-29777, . (13/14262-7)
PIRES, FILIPA; GERALDO, VANANELIA P. N.; ANTUNES, ANDREA; MARIETTA, ALEXANDRE; OLIVEIRA, JR., OSVALDO N.; RAPOSO, MARIA. On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 173, p. 312-319, . (13/14262-7)
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Patente(s) depositada(s) como resultado deste projeto de pesquisa

BIOSSENSOR PARA DETECÇÃO DE PAPILOMAVÍRUS HUMANO (HPV-16), PROCESSO DE PRODUÇÃO DE BIOSSENSOR E KIT DE DETECÇÃO PARA HPV-16 BR102019021171-7 - Fundação Pio XII (FP) ; Universidade de São Paulo (USP) . OSVALDO NOVAIS DE OLIVEIRA JUNIOR / ANA CAROLINA DE CARVALHO PETERS / ANDRÉ LOPES CARVALHO / ANDREY COATRINI SOARES / JOSÉ HUMBERTO TAVARES GUERREIRO FREGNANI / JULIANA COATRINI SOARES / LIDIA MARIA REBOLHO BATISTA ARANTES / MATIAS ELISEO MELENDEZ / RUI MANUEL VIEIRA REIS / VALQUIRIA DA CRUZ RODRIGUES - 08 de outubro de 2019

CÉLULA ELETROQUÍMICA PARA ESPECTROSCOPIA DE INFRAVERMELHO, ESPECTRÔMETRO UTILIZANDO A MESMA E SISTEMA DE ESPECTROSCOPIA DE INFRAVERMELHO BR1020190012935 - Universidade de São Paulo (USP) . Frank Nelson Crespilho ; Lucyano Jefferson Alves De Macêdo - 22 de janeiro de 2019

GENOSSENSOR DE DNA PARA DETECÇÃO DO BIOMARCADOR MGMT E SEU USO PARA DIAGNÓSTICO DE CÂNCER ESPINOCELULAR DE CABEÇA E PESCOÇO BR1020200232878 - Fundação Pio XII (FP) ; Universidade de São Paulo (USP) . LIDIA MARIA REBOLHO BATISTA ARANTES / OSVALDO NOVAIS DE OLIVEIRA JUNIOR / ANDRÉ LOPES CARVALHO / BRUNA PEREIRA SORROCHE / FLÁVIO MAKOTO SHIMIZU / MATIAS ELISEO MELENDEZ / OLIVIA CARR / PAULO AUGUSTO RAYMUNDO PEREIRA / PAULO BARBEITAS MIRANDA / RAFAEL DE OLIVEIRA PEDRO / RUI MANUEL VIEIRA REIS - 13 de novembro de 2020

BIOSSENSOR PARA DETECÇÃO DO BIOMARCADOR PCA3 BR1020200240757 - Fundação Pio XII (FP) ; Universidade de São Paulo (USP) . ANDRÉ LOPES CARVALHO / MATIAS ELISEO MELENDEZ / RUI MANUEL VIEIRA REIS / OSVALDO NOVAIS DE OLIVEIRA JUNIOR / ALEXANDRE CESAR SANTOS / ANDREY COATRINI SOARES / ELINEY FERREIRA LIMA / JULIANA COATRINI SOARES / VALQUIRIA DA CRUZ RODRIGUES - 25 de novembro de 2020