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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Study of in vitro degradation of brushite cements scaffolds

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Reno, Caroline de Oliveira [1] ; Pereta, Nicholas C. [1] ; Bertran, Celso A. [2] ; Motisuke, Mariana [1] ; de Sousa, Eliandra [1]
Total Authors: 5
[1] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Bioceram Lab, BR-12231280 Sao Paulo - Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Dept Phys Chem, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 25, n. 10, p. 2297-2303, OCT 2014.
Web of Science Citations: 8

An interest path to fabricate supports for tissue engineering is to foam calcium phosphate cement's pastes leading to an increase on material's total porosity and interconnectivity which facilitates cells' adhesion, proliferation and differentiation. The aim of this work is to develop scaffolds of brushite cement and to evaluate its in vitro degradation rate. Macroporosity was obtained by foaming the liquid phase with different non-ionic surfactants (Tween 80 and Lutensol ON-110). The foam stability was achieved by adding chitosan. The scaffolds were immersed in Ringers(A (R)) solution during 7, 14, 21 and 28 days and samples' microstructure, weight loss, mechanical resistance and apparent porosity were evaluated. Both scaffolds presented interconnected macropores with sizes ranging from 100 to 360 A mu m and total porosities higher than 60 %. These properties could facilitate cell infiltration, bone growth and vascularization. The scaffolds obtained in this work should be considered as promising materials for application in bone tissue engineering. (AU)

FAPESP's process: 12/21198-0 - Bioactive and reabsorbable calcium phosphate microspheres for drug delivery
Grantee:Caroline de Oliveira Renó
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/09240-9 - Calcium phosphate cement otimization for application in orthopedics and tissue engineering
Grantee:Mariana Motisuke
Support type: Regular Research Grants
FAPESP's process: 10/00863-0 - Processing and characterization of B-TCP/Al2O3 nanostructured scaffolds for biomedical applications
Grantee:Eliandra de Sousa Trichês
Support type: Regular Research Grants