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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors

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Author(s):
Gaester, Karen [1, 2] ; Fonseca, Luiz A. M. [3] ; Luiz, Olinda [3] ; Assone, Tatiane [1, 2] ; Fontes, Adriele Souza [1, 2] ; Costa, Fernando [1, 2] ; Duarte, Alberto J. S. [1, 2] ; Casseb, Jorge [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, Sao Paulo - Brazil
[2] Inst Trop Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 4, OCT 17 2014.
Web of Science Citations: 11
Abstract

Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk for HPV-related diseases. The mean of this study is to determine the prevalence ofHPV in the oral tract of HIV-1-positive male subjects and its association with risk factors. A total of 283 oral wash samples from HIV-1-positive men were tested. The oral fluid samples were used for DNA extraction and conventional PCR amplification; HPV genotyping was performed by hybridization. HPV genotyping revealed that nine samples (3.5%) were positive for HPV DNA; the major high-risk HPV types identified were 51 and 66. Worldwide studies have shown a variable prevalence of oral HPV. The diversity of genotypes and the high prevalence of multiple infections in HIV-infected subjects can be better explained by the effects of HIV-induced immunosuppression. The most important risk factors are unprotected sexual intercourse, but other factors for this infection have been described elsewhere including smoking, age and HIV-positive serostatus. In this study, smoking was the most important risk factor for acquiring oral HPV in HIV-1-infected subjects in Brazil. (AU)

FAPESP's process: 10/07076-4 - Prevalence and in vitro specific immune response to human papillomavirus (HPV) in HIV-1-infected men in the São Paulo City, Brazil.
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants
FAPESP's process: 11/16094-9 - Prevalence of HPV in oral fluid and its risk factors in HIV-1-infected men.
Grantee:Karen Eliane de Oliveira Gaester
Support Opportunities: Scholarships in Brazil - Master