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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases

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Author(s):
Ferreira, Caroline Marcantonio [1] ; Vieira, Angelica Thomaz [2] ; Ramirez Vinolo, Marco Aurelio [3] ; Oliveira, Fernando A. [4] ; Curi, Rui [5] ; Martins, Flaviano dos Santos [6]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, ICB 1, Inst Biomed Sci, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Genet, BR-31270901 Belo Horizonte, MG - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Biol Sci, Sect Physiol & Pharmacol, BR-09913030 Diadema, SP - Brazil
[5] Univ Sao Paulo, ICB 1, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
[6] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, BR-31270901 Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Review article
Source: CLINICAL & DEVELOPMENTAL IMMUNOLOGY; 2014.
Web of Science Citations: 64
Abstract

The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases. (AU)

FAPESP's process: 12/10653-9 - Role of short chain fatty acids and their receptor (GPR43) in the immune response to anaerobic bacteria in vivo and in vitro
Grantee:Marco Aurélio Ramirez Vinolo
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/50336-2 - Interaction among hypometabolism, calcium dynamics and neuronal excitability: implications in the degenerative process of Alzheimer's Disease
Grantee:Fernando Augusto de Oliveira Ribeiro
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/50410-8 - Effects of short-chain fatty acids produced by probiotic bacteria in the prophylaxis and treatment of allergic airway inflammation
Grantee:Caroline Marcantonio Ferreira
Support type: Research Grants - Young Investigators Grants