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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise Improves Immune Function, Antidepressive Response, and Sleep Quality in Patients with Chronic Primary Insomnia

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Passos, Giselle Soares [1] ; Poyares, Dalva [2] ; Santana, Marcos Goncalves [1] ; de Souza Teixeira, Alexandre Abilio [2] ; Lira, Fabio Santos [3] ; Youngstedt, Shawn D. [4, 5] ; Thomatieli dos Santos, Ronaldo Vagner [2] ; Tufik, Sergio [2] ; de Mello, Marco Tulio [2, 6]
Total Authors: 9
[1] Univ Fed Goias, Jatai, Go - Brazil
[2] Univ Fed Sao Paulo, Sao Paulo - Brazil
[3] Univ Estadual Paulista, Presidente Prudente, SP - Brazil
[4] Arizona State Univ, Coll Nursing & Hlth Innovat & Exercise & Wellness, Phoenix, AZ - USA
[5] Phoenix VA Hlth Care Syst, Phoenix, AZ - USA
[6] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Journal article
Web of Science Citations: 15

The aim of this study was to evaluate the effects of moderate aerobic exercise training on sleep, depression, cortisol, and markers of immune function in patients with chronic primary insomnia. Twenty-one sedentary participants (16 women aged 44.7 +/- 9 years) with chronic primary insomnia completed a 4-month intervention of moderate aerobic exercise. Compared with baseline, polysomnographic data showed improvements following exercise training. Also observed were reductions in depression symptoms and plasma cortisol. Immunologic assays revealed a significant increase in plasma apolipoprotein A (140.9 +/- 22 to 151.2 +/- 22mg/dL) and decreases in CD4 (915.6 +/- 361 to 789.6 +/- 310 mm(3)) and CD8 (532.4 +/- 259 to 435.7 +/- 204 mm(3)). Decreases in cortisol were significantly correlated with increases in total sleep time (r. = -0.51) and REMsleep (r. = -0.52). In summary, long-termmoderate aerobic exercise training improved sleep, reduced depression and cortisol, and promoted significant changes in immunologic variables. (AU)

FAPESP's process: 08/02862-1 - Effects of physical exercise on sleep quality of patients with primary chronic insomnia: a comparation of two different times of day
Grantee:Giselle Soares Passos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC