Pericardial Fat Is Associated with Coronary Artery Calcification in Non-Dialysis Dependent Chronic Kidney Disease Patients

Author(s)

Harada, Paulo H. N. ^[1] ; Canziani, Maria E. ^[2] ; Lima, Leonardo M. ^[1] ; Kamimura, Maria ^[2] ; Rochitte, Carlos E. ^[3] ; Lemos, Marcelo M. ^[2] ; Cuppari, Lilian ^[2] ; Kalil Filho, Roberto ^[1] ; Draibe, Sergio A. ^[2] ; Santos, Raul D. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Lipid Clin Heart Inst InCor, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Div Nephrol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Cardiovasc Magnet Resonance & Computed Tomog Sect, Heart Inst InCor, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS One; v. 9, n. 12 DEC 5 2014.
• Web of Science Citations: 4

Abstract

Pericardial fat (PF) a component of visceral adipose tissue has been consistently related to coronary atherosclerosis in the general population. This study evaluated the association between PF and coronary artery calcification (CAC) in non-dialysis dependent chronic kidney disease (CKD) patients. This is a post-hoc cross sectional analysis of the baseline of a prospective cohort of 117 outward CKD patients without manifest coronary artery disease (age, 56.9 +/- 11.0 years, 64.1% males, 95.1% hypertensives, 25.2% diabetics, 15.5% ever smokers, CKD stage 2 to 5 with estimated glomerular filtration rate 36.8 +/- 18.1 ml/min). CAC scores, PF volume and abdominal visceral fat (AVF) areas were measured by computed tomography. The association of PF as a continuous variable with the presence of CAC was analyzed by multivariate logistic regression. CAC (calcium score >0) was present in 59.2% patients. Those presenting CAC were on average 10 years older, had a higher proportion of male gender (78.7% vs. 42.9%, p<0.001), and had higher values of waist circumference (95.9 +/- 10.7 vs. 90.2 +/- 13.2 cm, p=0.02), PF volumes (224.8 +/- 107.6 vs. 139.1 +/- 85.0 cm(3), p<0.01) and AVF areas (109.2 +/- 81.5 vs. 70.2 +/- 62.9 cm(2), p=0.01). In the multivariate analysis, adjusting for age, gender, diabetes, smoking and, left ventricular concentric hypertrophy, PF was significantly associated with the presence of CAC (OR: 1.88 95% CI: 1.03-3.43 per standard deviation). PF remained associated with CAC even with additional adjustments for estimated glomerular filtration rate or serum phosphorus (OR: 1.85 95% CI: 1.00-3.42, p=0.05). PF is independently associated with CAC in non-dialysis dependent CKD patients. (AU)

• FAPESP's process: 11/14201-2 - Evaluation of subclinical atherosclerosis in individuals with makedly elevated HDL-cholesterol levels
• Grantee: Leonardo Mateus de Lima
• Support Opportunities: Scholarships in Brazil - Scientific Initiation