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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of carbon nanotubes network toxicity in zebrafish (danio rerio) model

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de Souza Filho, Jose [1] ; Matsubara, Elaine Y. [2] ; Franchi, Leonardo Pereira [3] ; Martins, Igor Pinheiro [1] ; Ramires Rivera, Luis Miguel [1] ; Rosolen, Jose Mauricio [2] ; Grisolia, Cesar Koppe [1]
Total Authors: 7
[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, Brasilia, DF - Brazil
[2] Univ Sao Paulo, FFCLRP, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Environmental Research; v. 134, n. SI, p. 9-16, OCT 2014.
Web of Science Citations: 16

This is a detailed in vivo study of the biological response to carbon nanotubes network as probed by the zebrafish model. First, we prepared pristine carbon nanotubes (CNTs) by methanol chemical vapor deposition in the presence of Mn and Co as catalysts, followed by purification in acid, which furnished curved tubes with diameters lying between 10 and 130 nm. The CNT network consisted of pristine CNTs dispersed in water in the presence of a surfactant. The CNT network pellets corresponded to agglomerated multi-walled CNTs with an average diameter of about 500 nm. Although the same pristine CNTs had been previously found to exert genotoxic effects in vitro, here we verified that the CNT network was not genotoxic in vivo. Indeed, Raman spectroscopy and microscopy conducted in the intestine of the zebrafish revealed complete clearance of the CNT network as well as minimal disturbances, such as aneurysms, hyperemia, and reversible inflammatory focus in the zebrafish gills. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/07681-5 - Development and study of micro/nanostructurated materials of interest for Lithium ion battery and capacitors
Grantee:Jose Mauricio Rosolen
Support type: Regular Research Grants
FAPESP's process: 10/10863-8 - Cytotoxic and genotoxic effects of nanoparticles in cell lines in vitro.
Grantee:Leonardo Pereira Franchi
Support type: Scholarships in Brazil - Doctorate