Pimentel, Gustavo D.
Carvalheira, Jose B. C.
Total Authors: 3
 Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Internal Med, Sao Paulo - Brazil
 Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 - USA
Total Affiliations: 2
Molecular and Cellular Endocrinology;
n. 1-2, SI,
NOV 25 2014.
Web of Science Citations:
The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)