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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory and sympathetic chemoreflex regulation by Kolliker-Fuse neurons in rats

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Author(s):
Damasceno, Roselia S. [1] ; Takakura, Ana C. [2] ; Moreira, Thiago S. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY; v. 467, n. 2, p. 231-239, FEB 2015.
Web of Science Citations: 5
Abstract

Chemoreceptor activation increases phrenic nerve activity (PNA) and sympathetic nerve activity (SNA). The dorsolateral pontine neurons, including the parabrachial nucleus and the Kolliker-Fuse (KF) region project to several brainstem areas involved in autonomic and respiratory regulation. Here the objective was to further test the hypothesis that the KF region could contribute to central and peripheral sympathetic chemoreflex activation. In urethane-anesthetized sino-aortic denervated or intact and vagotomized male Wistar rats (N = 7-8/group), hypercapnia (end-expiratory CO2 from 5 to 10 %) or KCN increased mean arterial pressure (MAP), splanchnic SNA, and PNA frequency and amplitude. Bilateral injection of muscimol (GABA-A agonist; 2 mM-50 nl) into the KF region increased resting PNA amplitude and reduced resting PNA frequency, without significant changes in resting MAP and SNA. Bilateral blockade of the KF region reduced the rise in MAP, sSNA, and PNA frequency and amplitude produced by hypercapnia or hypoxia. Our data suggest that the KF neurons could integrate and modulate breathing and sympathetic outflow during chemoreceptor activation. (AU)

FAPESP's process: 10/09776-3 - Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region
Grantee:Ana Carolina Thomaz Takakura
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 10/19336-0 - Pontine mechanisms involved in cardiorespiratory control during central or peripheral chemoreceptors activation
Grantee:Thiago dos Santos Moreira
Support type: Regular Research Grants
FAPESP's process: 10/15692-7 - Involvement of the Kolliker-Fuse in cardiorespiratory control during activation of central and peripheral chemoreceptors
Grantee:Rosélia dos Santos Damasceno
Support type: Scholarships in Brazil - Doctorate