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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Riboflavin derivatives for enhanced photodynamic activity against Leishmania parasites

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Author(s):
Silva, Alexandre Vieira [1, 2] ; Lopez-Sanchez, Almudena [3] ; Junqueira, Helena Couto [1] ; Rivas, Luis [3] ; Baptista, Mauricio S. [1] ; Orellana, Guillermo [2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Chem, Sao Paulo - Brazil
[2] Univ Complutense Madrid, Dept Organ Chem, E-28040 Madrid - Spain
[3] CSIC, Ctr Invest Biol, Dept Physicochem Biol, Madrid 28040 - Spain
Total Affiliations: 3
Document type: Journal article
Source: Tetrahedron; v. 71, n. 3, p. 457-462, JAN 21 2015.
Web of Science Citations: 6
Abstract

Riboflavin derivatives with various substituents (O-acyl, N-methyl, N-alkylcarboxyalkyl or N-alkyl(trialkyl) ammonium) have been prepared and spectroscopically characterized (absorption, emission and fluorescence quantum yields). Their quantum yields of photosensitized singlet molecular oxygen production (Phi(Delta) 0.24-0.58) and octanol/water partition coefficients (P-ow <= 0.01-11) were measured. Preliminary studies indicate that all derivatives display higher phototoxicity against the human protozoan parasite Leishmania than the parent riboflavin, with negligible toxicity in the absence of light. Their photodynamic action shows a higher correlation with Pow than with Phi(Delta), opening up their potential application to cutaneous diseases treatment. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support type: Research Projects - Thematic Grants