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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times

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Author(s):
Xavier-Neto, Jose [1, 2] ; Sousa Costa, Angela M. [1] ; Figueira, Ana Carolina M. [1] ; Caiaffa, Carlo Donato [1] ; do Amaral, Fabio Neves [1, 3] ; Cerqueira Peres, Lara Maldanis [1, 4] ; Pires da Silva, Barbara Santos [1, 3] ; Santos, Luana Nunes [1] ; Moise, Alexander R. [5] ; Castilo, Hozana Andrade [1]
Total Authors: 10
Affiliation:
[1] Brazilian Ctr Res Energy & Mat, Brazilian Natl Lab Biosci, BR-13083970 Campinas, SP - Brazil
[2] Brazilian Assoc Synchrotron Light Technol, Brazilian Natl Lab Biosci, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, Dept Cell & Dev Biol, Inst Biomed Sci, BR-05508 Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, Dept Pharmacol, Fac Med Sci, Campinas - Brazil
[5] Univ KS, Sch Pharm, Dept Pharmacol & Toxicol, Kansas City, KS - USA
Total Affiliations: 5
Document type: Review article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS; v. 1849, n. 2, SI, p. 94-111, FEB 2015.
Web of Science Citations: 22
Abstract

Retinoic acid (RA) is a terpenoid that is synthesized from vitamin A/retinol (ROL) and binds to the nuclear receptors retinoic acid receptor (RAR)/retinoid X receptor (RXR) to control multiple developmental processes in vertebrates. The available clinical and experimental data provide uncontested evidence for the pleiotropic roles of RA signaling in development of multiple embryonic structures and organs such eyes, central nervous system, gonads, lungs and heart. The development of any of these above-mentioned embryonic organ systems can be effectively utilized to showcase the many strategies utilized by RA signaling. However, it is very likely that the strategies employed to transfer RA signals during cardiac development comprise the majority of the relevant and sophisticated ways through which retinoid signals can be conveyed in a complex biological system. Here, we provide the reader with arguments indicating that RA signaling is exquisitely regulated according to specific phases of cardiac development and that RA signaling itself is one of the major regulators of the timing of cardiac morphogenesis and differentiation. We will focus on the role of signaling by RA receptors (RARs) in early phases of heart development. This article is part of a Special Issue entitled: Nuclear receptors in animal development (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/12008-6 - Studies of structure and function of aldehyde dehydrogenases involved in cellular signaling pathways and detoxification
Grantee:Fábio Neves do Amaral
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/14859-0 - Study on the molecular mechanisms of the orphan nuclear receptor COUP-TFII action during cardiac chambers development
Grantee:Carlo Donato Simões Caiaffa Feliciano de Carvalho
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/15273-7 - The role of nuclear receptors in the atrial specification
Grantee:Bárbara Santos Pires da Silva
Support type: Scholarships in Brazil - Master