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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Directed Metalation of 1-Ester-Substituted Indolizines: Base/Electrophile-Controlled Regioselective Functionalization

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Amaral, Monica F. Z. J. [1] ; Baumgartner, Amanda A. [1] ; Vessecchi, Ricardo [2] ; Clososki, Giuliano C. [1]
Total Authors: 4
[1] Univ Sao Paulo, Nucleo Pesquisas Prod Nat & Sintet, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ORGANIC LETTERS; v. 17, n. 2, p. 238-241, JAN 16 2015.
Web of Science Citations: 22

A variety of C-2 and C-5 difunctionalized indolizines have been prepared through the reaction of 1-ester-substituted indolizines with organometallic bases followed by a reaction with different electrophiles. Metalation takes place under mild conditions allowing the isolation of a number of difunctionalized indolizines in good yields. The regioselectivity of the reaction appears to be governed by the nature of the base and electrophile. (AU)

FAPESP's process: 13/04766-8 - Applycation of new organometallic reagents in the functionalization of substances of synthetic interest
Grantee:Giuliano Cesar Clososki
Support type: Regular Research Grants
FAPESP's process: 11/20742-6 - Application of organometallic reagents in the functionalization of indolizines of synthetic interest
Grantee:Mônica Franco Zannini Junqueira Toledo
Support type: Scholarships in Brazil - Doctorate