| Full text | |
| Author(s): |
Heredia-Vieira, Silvia C.
[1]
;
Simonet, Ana M.
[2]
;
Vilegas, Wagner
[3]
;
Macias, Francisco A.
[2]
Total Authors: 4
|
| Affiliation: | [1] Univ Estadual Paulista, UNESP, Fac Pharmaceut Sci, BR-14801902 Sao Paulo - Brazil
[2] Univ Cadiz, Fac Ciencias, Inst Biomol INBIO, Dept Quim Organ, Grp Alelopatia, Puerto Real 11510, Cadiz - Spain
[3] Univ Estadual Paulista, UNESP, BR-11330900 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 78, n. 1, p. 77-84, JAN 2015. |
| Web of Science Citations: | 9 |
| Abstract | |
A phytochemical study of a Serjania marginata leaf extract with antiulcer activity afforded 15 compounds, including the new 3-O-alpha-L-arabinopyranosyl(1 -> 3)-alpha-L-rhamnopyranosyl(1 -> 2){[}beta-D-glucopyranosyl(1 -> 4)]-alpha-L-arabinopyranosyloleanolic acid (1) and 7,5 `'-anhydroapigenin 8-C-alpha-(2,6-dideoxy-5-hydroxy-ribo-hexopyranosyl)-4'-O-beta-D-glucopy ranoside (4). The structures of the new compounds were determined by spectroscopic analysis, including 1D and 2D NMR techniques, mass spectrometry, and chemical methods. Compound 4 is a C-hexopyranosylapigenin with an unusual cyclic ether linkage between C-5 `' and C-7 of apigenin. The isolated proanthocyanidins have high antioxidant activities, and these compounds are probably responsible for the gastroprotective effect of the extract. (AU) | |
| FAPESP's process: | 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases |
| Grantee: | Wagner Vilegas |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 11/08880-4 - Standardized extracts for the treatment of chronic diseases |
| Grantee: | Silvia Cristina Heredia Vieira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |