Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction

Author(s)

Torina, Anali Galluce ^[1] ; Reichert, Karla ^[1] ; Lima, Fany ^[1] ; de Souza Vilarinho, Karlos Alexandre ^[1] ; Martins de Oliveira, Pedro Paulo ^[2] ; Pereira do Carmo, Helison Rafael ^[1] ; de Carvalho, Daniela Diogenes ^[1] ; Abdalla Saad, Mario Jose ^[3] ; Sposito, Andrei Carvalho ^[3] ; Petrucci, Orlando ^{[1, 2]}

Affiliation

^[1] State Univ Campinas UNICAMP, Fac Med Sci, Lab Myocardial Ischemia Reperfus, Campinas, SP - Brazil

^[2] State Univ Campinas UNICAMP, Fac Med Sci, Dept Surg, Discipline Cardiac Surg, Campinas, SP - Brazil

^[3] State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP - Brazil

• Document type: Journal article
• Source: PLoS One; v. 10, n. 3 MAR 27 2015.
• Web of Science Citations: 12

Abstract

Background The inflammatory response has been implicated in the pathogenesis of left ventricular (LV) remodeling after myocardial infarction (MI). An anthraquinone compound with anti-inflammatory properties, diacerein inhibits the synthesis and activity of pro-inflammatory cytokines, such as tumor necrosis factor and interleukins 1 and 6. The purpose of this study was to investigate the effects of diacerein on ventricular remodeling in vivo. Methods and Results Ligation of the left anterior descending artery was used to induce MI in an experimental rat model. Rats were divided into two groups: a control group that received saline solution (n = 16) and a group that received diacerein (80 mg/kg) daily (n = 10). After 4 weeks, the LV volume, cellular signaling, caspase 3 activity, and nuclear factor kappa B (NF-kappa B) transcription were compared between the two groups. After 4 weeks, end-diastolic and end-systolic LV volumes were reduced in the treatment group compared to the control group (p < .01 and p < .01, respectively). Compared to control rats, diacerein-treated rats exhibited less fibrosis in the LV (14.65% +/- 7.27% vs. 22.57% +/- 8.94%; p < .01), lower levels of caspase-3 activity, and lower levels of NF-kappa B p65 transcription. Conclusions Treatment with diacerein once a day for 4 weeks after MI improved ventricular remodeling by promoting lower end-systolic and end-diastolic LV volumes. Diacerein also reduced fibrosis in the LV. These effects might be associated with partial blockage of the NF-kappa B pathway. (AU)

• FAPESP's process: 11/14550-7 - The diacerein properties on the left ventricle remodeling after acute myocardial infarction: experimental study
• Grantee: Orlando Petrucci Jr
• Support Opportunities: Regular Research Grants