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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zinc Prevents Sickness Behavior Induced by Lipopolysaccharides after a Stress Challenge in Rats

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Kirsten, Thiago B. [1, 2] ; Galvao, Marcella C. [1] ; Reis-Silva, Thiago M. [1] ; Queiroz-Hazarbassanov, Nicolle [1] ; Bernardi, Maria M. [2]
Total Authors: 5
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo - Brazil
[2] Univ Estadual Paulista, Environm & Expt Pathol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 10, n. 3 MAR 16 2015.
Web of Science Citations: 9

Sickness behavior is considered part of the specific beneficial adaptive behavioral and neuroimmune changes that occur in individuals in response to infectious/inflammatory processes. However, in dangerous and stressful situations, sickness behavior should be momentarily abrogated to prioritize survival behaviors, such as fight or flight. Taking this assumption into account, we experimentally induced sickness behavior in rats using lipopolysaccharides (LPS), an endotoxin that mimics infection by gram-negative bacteria, and then exposed these rats to a restraint stress challenge. Zinc has been shown to play a regulatory role in the immune and nervous systems. Therefore, the objective of this study was to examine the effects of zinc treatment on the sickness response of stress-challenged rats. We evaluated 22-kHz ultrasonic vocalizations, open-field behavior, tumor necrosis factor a (TNF-alpha), corticosterone, and brain-derived neurotrophic factor (BDNF) plasma levels. LPS administration induced sickness behavior in rats compared to controls, i.e., decreases in the distance traveled, average velocity, rearing frequency, self-grooming, and number of vocalizations, as well as an increase in the plasma levels of TNF-alpha, compared with controls after a stressor challenge. LPS also decreased BDNF expression but did not influence anxiety parameters. Zinc treatment was able to prevent sickness behavior in LPS-exposed rats after the stress challenge, restoring exploratory/motor behaviors, communication, and TNF-alpha levels similar to those of the control group. Thus, zinc treatment appears to be beneficial for sick animals when they are facing risky/stressful situations. (AU)

FAPESP's process: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships
Grantee:João Palermo Neto
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/07007-8 - Possible prevention or treatment of impairments induced by an early prenatal exposure to lipopolysaccharide in an experimental model of autism
Grantee:Thiago Berti Kirsten
Support type: Scholarships in Brazil - Post-Doctorate