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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endothelial Progenitor Cells in Tumor Angiogenesis: Another Brick in the Wall

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Marcola, Marina [1] ; Rodrigues, Camila Eleuterio [2]
Total Authors: 2
[1] Univ Sao Paulo, Inst Biosci, Dept Physiol, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Med Invest Lab 12, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 28

Until 15 years ago, vasculogenesis, the formation of new blood vessels from undifferentiated cells, was thought to occur only during embryonic development. The discovery of circulating cells that are able to promote vascular regeneration and repair-the so-called endothelial progenitor cells (EPCs)-changed that, and EPCs have since been studied extensively. It is already known that EPCs include many subtypes of cells that play a variety of roles in promoting vascular growth. Some EPCs are destined to differentiate into endothelial cells, whereas others are capable of promoting and sustaining angiogenesis through paracrine mechanisms. Vasculogenesis and angiogenesis might constitute complementary mechanisms for postnatal neovascularization, and EPCs could be at the core of this process. Although the formation of new blood vessels from preexisting vasculature plays a beneficial role in many physiological processes, such as wound healing, it also contributes to tumor growth and metastasis. However, many aspects of the role played by EPCs in tumor angiogenesis remain unclear. This review aims to address the main aspects of EPCs differentiation and certain characteristics of their main function, especially in tumor angiogenesis, as well as the potential clinical applications. (AU)

FAPESP's process: 11/01304-8 - Effect of melatonin on the subpopulations of cultured endothilial cells
Grantee:Marina Marçola Pereira de Freitas
Support type: Scholarships in Brazil - Doctorate