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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action

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de Melo Carrasco, Leticia Dias [1, 2] ; Mello Sampaio, Jorge Luiz [2] ; Carmona-Ribeiro, Ana Maria [1, 2]
Total Authors: 3
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05513970 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 16, n. 3, p. 6337-6352, 2015.
Web of Science Citations: 10

The growing challenge of antimicrobial resistance to antibiotics requires novel synthetic drugs or new formulations for old drugs. Here, cationic nanostructured particles (NPs) self-assembled from cationic bilayer fragments and polyelectrolytes are tested against four multidrug-resistant (MDR) strains of clinical importance. The non-hemolytic poly(diallyldimethylammonium) chloride (PDDA) polymer as the outer NP layer shows a remarkable activity against these organisms. The mechanism of cell death involves bacterial membrane lysis as determined from the leakage of inner phosphorylated compounds and possibly disassembly of the NP with the appearance of multilayered fibers made of the NP components and the biopolymers withdrawn from the cell wall. The NPs display broad-spectrum activity against MDR microorganisms, including Gram-negative and Gram-positive bacteria and yeast. (AU)

FAPESP's process: 11/00046-5 - Interactions between membranes, biomolecules and surfaces
Grantee:Ana Maria Carmona-Ribeiro
Support type: Regular Research Grants
FAPESP's process: 12/24534-1 - Supramolecular assemblies of cationic lipid, antibiotics and polymers: preparation, characterization and activity against multiresistant bacteria and fast-growing mycobacteria
Grantee:Letícia Dias de Melo Carrasco
Support type: Scholarships in Brazil - Doctorate