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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats

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da Cunha, Marcelo Rodrigues [1, 2] ; Menezes, Fernanda Araujo [1] ; dos Santos, Geovane Ribeiro [2] ; Lopes Pinto, Clovis Antonio [2] ; Barraviera, Benedito [3] ; Amaro Martins, Virginia da Conceicao [4] ; de Guzzi Plepis, Ana Maria [4] ; Ferreira Junior, Rui Seabra [3]
Total Authors: 8
[1] Ctr Univ Padre Anchieta UniAnchieta, Lab Anat, BR-13207270 Jundiai, SP - Brazil
[2] Fac Med Jundiai FMJ, Dept Morfol & Patol Basica, BR-13202550 Jundiai, SP - Brazil
[3] Univ Estadual Paulista Julio de Mesquista Filho U, CEVAP, BR-18610307 Botucatu, SP - Brazil
[4] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 11

Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair. (AU)

FAPESP's process: 09/53846-9 - Recent acquisition of preparative high-performance liquid chromatograph for the purification and isolation of serine proteinases to produce fibrin sealant
Grantee:Benedito Barraviera
Support type: Multi-user Equipment Program
FAPESP's process: 12/02689-3 - Use of fibrin sealant associated with hydroxyapatite in repair of bone defects induced in rat calvaria
Grantee:Fernanda de Araujo Menezes
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/08101-8 - In vivo imaging of nerve regeneration following ventral root replantation with fluo-stained fibrin sealant associated with mesenchymal stem cells
Grantee:Rui Seabra Ferreira Junior
Support type: Regular Research Grants
FAPESP's process: 09/06280-0 - Sexual, ontogenetic and enviromental variation in the venom of Crotalus durissus terrificus and Bothrops jararaca on Botucatu region - Sao Paulo State - Brazil: Pharmacological, Biochemical and Enzymatical Characterization.
Grantee:Rui Seabra Ferreira Junior
Support type: Regular Research Grants