(-)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus

Author(s)

de Souza, Gabriela F. P. ^[1] ; Novaes, Luiz F. T. ^[2] ; Avila, Carolina M. ^[2] ; Nascimento, Lucas F. R. ^[1] ; Velloso, Licio A. ^[1] ; Pilli, Ronaldo A. ^[2]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Lab Cell Signaling, BR-13084761 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13084971 Sao Paulo - Brazil

• Document type: Journal article
• Source: Molecules; v. 20, n. 3, p. 5038-5049, 2015.
• Web of Science Citations: 2

Abstract

A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant. (AU)

• FAPESP's process: 12/09254-2 - Synthesis of the tarchonanthuslactone, analogues and evaluation of anticancer and antidiabetic activity
• Grantee: Luiz Fernando Toneto Novaes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 10/08673-6 - Studies toward the Synthesis of Analogues of Fostriecin and Total Synthesis and Structural Elucidation of Coibacinas A and B
• Grantee: Carolina Martins Avila de Sant'Ana
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC