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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

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Author(s):
de Sousa, Michelle Cardoso [1] ; Vieira, Rafael Brizola [1] ; dos Santos, Danielle Sa [1] ; Talge Carvalho, Claudio Antonio [2] ; Afonso Camargo, Samira Esteves [1] ; Gasparoto Mancini, Maria Nadir [1] ; de Oliveira, Luciane Dias [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Dept Restorat Dent, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 60, n. 4, p. 600-605, APR 2015.
Web of Science Citations: 11
Abstract

Background: The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS). Methods: Saliva samples were collected from 30 patients with DS and control group (age: 1424 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed. Results: Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p < 0.05). Conversely, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p > 0.05). Conclusion: Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/51228-6 - Evaluation of antioxidants and biomarkers of oxidative stress in the saliva of patients with Down's syndrome
Grantee:Luciane Dias de Oliveira
Support Opportunities: Regular Research Grants