Immunophenotypic Profile and Increased Risk of Hos... - BV FAPESP
Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Full text
Author(s):
Ono, E. [1] ; dos Santos, A. M. [2] ; Viana, P. O. [1] ; Dinelli, M. I. S. [1] ; Sass, N. [3] ; De Oliveira, L. [3] ; Goulart, A. L. [2] ; de Moraes-Pinto, M. I. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pediat, Div Neonatal Med, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AMERICAN JOURNAL OF TRANSPLANTATION; v. 15, n. 6, p. 1654-1665, JUN 2015.
Web of Science Citations: 9
Abstract

Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women. (AU)

FAPESP's process: 08/06232-2 - The immune system in children born to renal transplant recipient women: Phenotypic and functional evaluation at birth and during the second half of the first year of life
Grantee:Erika Ono Kawaoku
Support Opportunities: Scholarships in Brazil - Doctorate