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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up

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Author(s):
Dias Goncalves, Tiago Eduardo [1] ; Santos Zimmermann, Glaucia [1, 2] ; Cristina Figueiredo, Luciene [1] ; de Carvalho Souza, Monique [1] ; Ferreira da Cruz, Daniele [1] ; Ferreira Bastos, Marta [1] ; Pereira da Silva, Helio Doyle [3] ; Mendes Duarte, Poliana [1]
Total Authors: 8
Affiliation:
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
[2] Univ Fed Santa Catarina, Dept Dent, Florianopolis, SC - Brazil
[3] Univ Barcelona, Dept Publ Hlth, Biostat Unit, Barcelona - Spain
Total Affiliations: 3
Document type: Journal article
Source: Journal of Clinical Periodontology; v. 42, n. 5, p. 431-439, MAY 2015.
Web of Science Citations: 21
Abstract

AimThis study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) and serum levels of adipokines in patients with chronic periodontitis (CP) with or without obesity. MethodsTwenty patients with obesity and 20 patients without obesity, all with CP, received SRP. Serum and GCF levels of resistin, adiponectin, leptin, tumour necrosis factor {[}TNF]- and interleukin {[}IL]-6 were evaluated by enzyme-linked immunosorbent assay at baseline, 3, 6 and 12months post-therapy. ResultsSRP reduced the amounts of TNF- in deep sites and increased the concentration of adiponectin in shallow sites of non-obese patients (p<0.05). SRP increased the concentrations of TNF- and leptin in patients with obesity (p<0.05). GCF levels of TNF- were higher in patients with obesity than in patients without obesity at all time-points (p<0.05). There were no changes in serum levels of any adipokines for any group after therapy (p>0.05). Patients with obesity exhibited higher serum levels of leptin at all time-points and IL-6 at 3months post-therapy (p<0.05). ConclusionsObesity may modulate systemic and periodontal levels of adipokines in favour of pro-inflammation, independently of periodontal therapy. SRP did not affect the circulating levels of adipokines in patients with or without obesity. (AU)

FAPESP's process: 11/14875-3 - Effects of basic periodontal therapy on clinical parameters and levels of adipocytokines in obese subjects with chronic periodontitis
Grantee:Tiago Eduardo Dias Gonçalves
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/01072-5 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants