Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unraveling the Biosynthesis of Pilocarpine in Pilocarpus microphyllus

Christine, Alexandra [1] ; Sawaya, Helena Frankland [1] ; Costa, Yanna Dias [1] ; Mazzafera, Paulo [1]
Total Authors: 4
[1] State Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NATURAL PRODUCT COMMUNICATIONS; v. 10, n. 5, p. 721-724, MAY 2015.
Web of Science Citations: 1

Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids related to pilocarpine have been reported in the previous years, little is still known about its biosynthetic route. At most, histidine has been reported as the precursor of pilocarpine. Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllophiline and anhydropilosine) were supplied to P. microphyllus leaves and the alkaloid profile analyzed by UPLC-MS, we suggest a biosynthesis pathway for pilocarpine. Further experiments using labeled precursors associated with transcriptome data may allow us to understand the whole biosynthesis pathway and its genetic control. (AU)

FAPESP's process: 09/00773-4 - Isolation and identification of imidazole alkaloids in JABORANDI (Pilocarpus microphyllus) and evaluation of their biological ACIVITY
Grantee:Alexandra Christine Helena Frankland Sawaya
Support type: Regular Research Grants