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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus

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Author(s):
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Vasconcelos, Andrea Rodrigues [1] ; Kinoshita, Paula Fernanda [1] ; Yshii, Lidia Mitiko [1] ; Marques Orellana, Ana Maria [1] ; Boehmer, Ana Elisa [1] ; Lima, Larissa de Sa [1] ; Alves, Rosana [1] ; Andreotti, Diana Zukas [1] ; Marcourakis, Tania [2] ; Scavone, Cristoforo [1] ; Kawamoto, Elisa Mitiko [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, Mol Neuropharmacol Lab, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Clin & Toxicol Anal, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NEUROBIOLOGY OF AGING; v. 36, n. 5, p. 1914-1923, MAY 2015.
Web of Science Citations: 12
Abstract

Chronic neuroinflammation is a common characteristic of neurodegenerative diseases, and lipopolysaccharide (LPS) signaling is linked to glutamate-nitric oxide-Na,K-ATPase isoforms pathway in central nervous system (CNS) and also causes neuroinflammation. Intermittent fasting (IF) induces adaptive responses in the brain that can suppress inflammation, but the age-related effect of IF on LPS modulatory influence on nitric oxide-Na,K-ATPase isoforms is unknown. This work compared the effects of LPS on the activity of alpha(1), alpha(2,3) Na,K-ATPase, nitric oxide synthase gene expression and/or activity, cyclic guanosine monophosphate, 3-nitrotyrosineecontaining proteins, and levels of thiobarbituric acidereactive substances in CNS of young and older rats submitted to the IF protocol for 30 days. LPS induced an agerelated effect in neuronal nitric oxide synthase activity, cyclic guanosine monophosphate, and levels of thiobarbituric acidereactive substances in rat hippocampus that was linked to changes in a2,3-Na,KATPase activity, 3-nitrotyrosine proteins, and inducible nitric oxide synthase gene expression. IF induced adaptative cellular stress-response signaling pathways reverting LPS effects in rat hippocampus of young and older rats. The results suggest that IF in both ages would reduce the risk for deficits on brain function and neurodegenerative disorders linked to inflammatory response in the CNS. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/10303-5 - TRAF6 and alfa-synuclein interaction and the subsequent modulation of signaling pathways
Grantee:Lidia Mitiko Yshii
Support type: Scholarships in Brazil - Post-Doctorate