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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Coaxial nanofibers of chitosan-alginate-PEO polycomplex obtained by electrospinning

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Author(s):
Guerra Nista, Silvia Vaz [1] ; Bettini, Jefferson [2] ; Innocentini Mei, Lucia Helena [1]
Total Authors: 3
Affiliation:
[1] State Univ Campinas UNICAMP, Sch Chem Engn, Dept Mat Engn & Bioproc, Campinas, SP - Brazil
[2] Brazilian Nanotechnol Natl Lab, Electron Microscopy Lab, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Carbohydrate Polymers; v. 127, p. 222-228, AUG 20 2015.
Web of Science Citations: 34
Abstract

Electrospinning of mucoadhesive membranes is a new and promising field of investigation in the pharmaceutical and biomedical area. The present study explored the electrospinning of two mucoadhesive polymers, chitosan and alginate, to form a core-shell type nanofibers for future applications as controlled drug delivery. Due to the charged functional groups present in these natural polysaccharides, they can complex to,yield various nanodevices to be used in controlled release of several active ingredients. In this work, the core-shell type coaxial nanofibers formation was evidenced by the aid of transmission electron microscopy (TEM). Other characterization techniques as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Infrared spectroscopy (FTIR) and X-ray diffraction (XRD), strongly suggest the formation of different molecular structures of the membranes obtained by the complexation of chitosan and alginate. Swelling rate and weight loss tests followed by SEM analyses confirmed that the nanofiber structure of these membranes were kept even after incubating them for 24h in water. The results of this work confirmed that core-shell nanofibers made of chitosan and alginate polycomplex is possible to be obtained with success. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/04877-4 - High adhesive nanofibers membrane to oral delivery of drugs
Grantee:Lucia Helena Innocentini Mei
Support Opportunities: Regular Research Grants
FAPESP's process: 12/11904-5 - High adhesive nanofibers membrane to oral delivery of drugs.
Grantee:Silvia Vaz Guerra Nista
Support Opportunities: Scholarships in Brazil - Doctorate