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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Raloxifene enhances peri-implant bone healing in osteoporotic rats

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Ramalho-Ferreira, G. [1, 2] ; Faverani, L. P. [1, 2] ; Prado, F. B. [3] ; Garcia, Jr., I. R. [1, 2] ; Okamoto, R. [4]
Total Authors: 5
[1] Univ Estadual Paulista UNESP, Dept Surg, Aracatuba Dent Sch, BR-16015050 Sao Paulo - Brazil
[2] Univ Estadual Paulista UNESP, Integrated Clin, Aracatuba Dent Sch, BR-16015050 Sao Paulo - Brazil
[3] Univ Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Dept Morphol, Sao Paulo - Brazil
[4] Univ Estadual Paulista UNESP, Dept Basic Sci, Aracatuba Dent Sch, BR-16015050 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: International Journal of Oral and Maxillofacial Surgery; v. 44, n. 6, p. 798-805, JUN 2015.
Web of Science Citations: 19

The aim of this study was to evaluate bone healing at the bone implant interface in rats with induced osteoporosis. The rats underwent a bilateral ovariectomy (OVX) and were fed a low calcium and phosphate diet. The OVX rats were divided into three groups: one was treated with raloxifene (OVX-RAL), one with alendronate (OVX-ALE), and one received no medication (OVX-NT). The control group rats (SHAM-DN) underwent sham surgery and were fed a normal diet. Each animal received one implant in each tibia: a machined surface implant in the right tibia and an implant with surface etching in the left tibia. All animals were euthanized after 42 days. Analysis of variance (ANOVA) and Tukey post hoc tests were applied to the biomechanics (reverse torque) and bone implant contact (BIC) data (P < 0.05). The RAL and ALE groups showed improved pen-implant bone healing. However, the ALE group showed no significant difference from the OVX-NT group. Surface treatment promoted higher corticalization at the bone implant interface, but showed the same characteristics of mature bone and bone neoformation in concentric laminations as the machined implant. There were no statistically significant differences in reverse torque (P = 0.861) or BIC (P = 0.745) between the OVX-RAL and SHAM-DN groups. Therefore, the use of raloxifene resulted in good biomechanical, BIC, and histological findings in the treatment of induced osteoporosis in rats. (AU)

FAPESP's process: 12/15912-2 - Evaluation of bone repair in the bone / implant interface in osteoporotic rats treated with raloxifene or alendronate: a histometrical, immunohistochemical, epifluorescence and biomecanical analysis
Grantee:Roberta Okamoto
Support Opportunities: Regular Research Grants
FAPESP's process: 12/15748-8 - Evaluation of bone healing at the bone-implant interface in rats with induced osteoporosis treated with raloxifene or alendronate - Histometric, immunohistochemical, biomechanical, and microscopy epifluorescence analysis.
Grantee:Gabriel Ramalho Ferreira
Support Opportunities: Scholarships in Brazil - Doctorate