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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-androgenic activities of diuron and its metabolites in male Nile tilapia (Oreochromis niloticus)

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Boscolo Pereira, Thiago Scremin [1] ; Pereira Boscolo, Camila Nomura [1] ; Humberto da Silva, Danilo Gruenig [2] ; Batlouni, Sergio Ricardo [3] ; Schlenk, Daniel [4] ; de Almeida, Eduardo Alves [2]
Total Authors: 6
[1] Univ Estadual Paulista, Dept Anim Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista, IBILCE, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista CAUNESP, Dept Aquaculture, BR-14884900 Jaboticabal, SP - Brazil
[4] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 - USA
Total Affiliations: 4
Document type: Journal article
Source: AQUATIC TOXICOLOGY; v. 164, p. 10-15, JUL 2015.
Web of Science Citations: 14

Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a widely used herbicide which has been frequently detected in surface waters throughout the world. In vivo bioassay guided fractionation studies indicated that diuron may have estrogenic activity augmented by biotransformation. This study evaluated the effects of diuron and three of its metabolites on plasma hormone concentrations and spermatogenesis of the freshwater fish Nile tilapia (Oreochromis niloticus). Sexually mature male fish were exposed for 25 days to diuron, as well to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 200 ng/L. Testosterone levels were decreased by diuron, but had limited effects on gonadal histology. Diuron metabolites, however, caused significant decreases in testosterone and in 11-ketotestosterone, gonadosomatic index, diameter of seminiferous tubules and in the mean percentages of germ cells (spermatids and spermatozoa). We conclude that these metabolites have antiandrogenic activity to male Nile tilapia, potentially causing reproductive impairment in male fish. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/52061-8 - Biochemical and estrogenic effects of Diuron and its metabolites, alone or in combination with alkylphenols in Nile Tilapia (Oreochromis niloticus)
Grantee:Eduardo Alves de Almeida
Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants