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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternally acquired IgG immunity in neonates born to renal transplanted women

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Viana, Patricia Oliveira [1] ; Ono, Erika [1] ; Saraiva Dinelli, Maria Isabel [1] ; Costa-Carvalho, Beatriz Tavares [1] ; Nunes dos Santos, Amelia Miyashiro [1] ; Sass, Nelson [2] ; de Moraes-Pinto, Maria Isabel [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Vaccine; v. 33, n. 27, p. 3104-3109, JUN 17 2015.
Web of Science Citations: 4

Neonates born to renal transplanted women are exposed in utero to immunosuppressors and to antenatal conditions that may predispose the neonate to a high risk of prematurity and intrauterine growth retardation. These factors might interfere with the transfer of maternal IgG immunity. Total IgG levels and specific antibodies to measles, varicella, tetanus, Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (serotypes 4,6B,9V,14,18C,19F and 23F) were evaluated on maternal and cord blood samples of 23 sets of renal transplanted women and their newborns and 32 sets of healthy women-newborns at term. Total IgG levels were measured by nephelometry and specific antibodies, by ELISA. Renal transplanted mothers had lower median tetanus antibodies (0.67 IU/mL) than controls (1.53 IU/mL; p = 0.017). Neonates from renal transplanted mothers had lower median tetanus antibodies (0.95 IU/mL) than controls (1.97 IU/mL, p = 0.008). Antibodies to measles, varicella, Hib and the 7 serotypes of S. pneumoniae were similar between groups. Maternal antibodies were associated with an increase in neonatal antibodies for all antigens; gestational age was associated with an increase in Hib neonatal antibodies. Preeclampsia was associated with a decrease in neonatal total IgG and serotype 4 S. pneumoniae antibodies; chronic hypertension was associated with a decrease in neonatal serotype 6B S. pneumoniae antibodies. As neonates from transplanted women may be born with lower tetanus antibodies than controls, efforts should be made to keep maternal vaccines up-to-date. Clinical antenatal care with control of preeclampsia, chronic hypertension and prevention of premature delivery might also contribute to neonatal antibody levels to specific antigens at birth. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/11670-9 - Children born to renal transplant recipients: immunologic assessment, placental antibody transfer and response to vaccination
Grantee:Maria Isabel de Moraes Pinto
Support Opportunities: Regular Research Grants
FAPESP's process: 09/01179-9 - Placental antibody transfer in children born to renal transplant recipient women
Grantee:Patrícia Oliveira Viana
Support Opportunities: Scholarships in Brazil - Doctorate