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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nature-inspired enzymatic cascades to build valuable compounds

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Sigrist, Renata [1] ; da Costa, Bruna Zucoloto [1] ; Marsaioli, Anita Jocelyne [1] ; de Oliveira, Luciana Gonzaga [1]
Total Authors: 4
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: BIOTECHNOLOGY ADVANCES; v. 33, n. 5, SI, p. 394-411, SEP-OCT 2015.
Web of Science Citations: 18

Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp.
Grantee:Renata Sigrist
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/10378-5 - Purification and functional characterization of copper mine microbial oxidoreductases enzymes
Grantee:Bruna Zucoloto da Costa
Support type: Scholarships in Brazil - Doctorate