Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort

Author(s)

Fernandes, Ariana Ester ^{[1, 2]} ; de Melo, Maria Edna ^{[1, 2]} ; Hiwatashi Fujiwara, Clarissa Tamie ^{[1, 2]} ; Pioltine, Marina Brosso ^{[1, 2]} ; Matioli, Sergio Russo ^[3] ; Santos, Aritania ^[2] ; Cercato, Cintia ^[1] ; Halpern, Alfredo ^[1] ; Mancini, Marcio C. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Fac Med, League Childhood Obes, Serv Endocrinol & Metab, BR-05403000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Lab Carbohydrates & Radioimmunoassay LIM 18, BR-01246903 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Biol, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ENDOCRINE; v. 49, n. 3, p. 653-658, AUG 2015.
• Web of Science Citations: 5

Abstract

Polymorphisms near the MC4R gene may be related to an increased risk for obesity, but studies of variations in this gene and its relation to cardiometabolic profiles and food intake are scarce and controversial. The aim of this study is to evaluate the influence of the variants rs12970134 and rs17782313 near the MC4R gene in food intake, binge eating (BE) behavior, anthropometric parameters, body composition, metabolic profile, and cardiometabolic risk factors in obese children and adolescents. This is a cross-sectional study that included obese children and adolescents. We evaluated anthropometric, metabolic parameters and cardiometabolic risk factors, including hypertension, impaired fasting glucose, hypertriglyceridemia, and low HDL-cholesterol. BE was assessed through the BE scale, and a 24-h recall was used to evaluate total caloric intake and percentage of macronutrients and types of dietary fat. The MC4R variants rs12970134 and rs17782313 were genotyped using TaqMan assay. To assess the magnitude of risk, a logistic regression adjusted for Z-BMI, age, and gender was performed, adopting the significance level of 0.05. The study included 518 subjects (52.1 % girls, 12.7 +/- A 2.7 years old, Z-BMI = 3.24 +/- A 0.57). Carriers of the variant rs17782313 exhibit increased triglyceride levels (108 +/- A 48 vs. 119 +/- A 54, p = 0.034) and an increased risk of hypertriglyceridemia (OR 1.985, 95 % CI 1.288-3.057, p = 0.002). There was no association of the SNP rs12970134 with clinical, metabolic, or nutritional parameters. The variant rs12970134 and rs17782313 did not influence food intake or the presence of BE. The variant rs17782313 is associated with an increased risk of hypertriglyceridemia in obese children and adolescents. (AU)

• FAPESP's process: 11/23340-6 - Effect of polymorphisms in LEP, LEPR and MC4R genes over eating behavior in obese children and adolescents
• Grantee: Marcio Corrêa Mancini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/05320-8 - Effect of the allelic variations in melanocortin-4 receptor gene on feeding behavior in obese children and adolescents
• Grantee: Ariana Ester Fernandes
• Support Opportunities: Scholarships in Brazil - Master