| Full text | |
| Author(s): |
Castoldi, Angela
[1]
;
de Aguiar, Cristhiane Favero
[1]
;
Moraes-Vieira, Pedro Manoel
[2]
;
Saraiva Camara, Niels Olsen
[3, 1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Dept Imunol, BR-05508900 Sao Paulo, SP - Brazil
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Metab & Diabet, Boston, MA 02205 - USA
[3] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | CURRENT PROTEIN & PEPTIDE SCIENCE; v. 16, n. 7, p. 655-671, 2015. |
| Web of Science Citations: | 9 |
| Abstract | |
Homeostasis of the immune system depends on several factors. The gastrointestinal tract plays an important role in maintaining our immune system. With this aim, the intestinal immune system interacts with epithelial barrier molecules, especially tight junction proteins, that are key molecules involved in controlling paracellular permeability to increase the protection barrier against external antigens or possibly to respond to commensal microorganisms. During intestinal inflammatory diseases, the expression of innate immune receptors in intestinal epithelial cells and infiltration of immune cells are related, but it is still unclear how the immune system induces modulation of paracellular permeability. In this review, we provide an overview of the understanding of how the immune system modulates the expression of tight junctions to maintain the mucosal immune system. (AU) | |
| FAPESP's process: | 14/10828-9 - Function of intestinal lamina propria NKT cells |
| Grantee: | Cristhiane Favero de Aguiar |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches |
| Grantee: | Niels Olsen Saraiva Câmara |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/16794-3 - Influence of gut microbiota on NKT cells profile in an experimental model of colitis |
| Grantee: | Cristhiane Favero de Aguiar |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/02218-6 - A study of the signaling pathways induced by RBP4 in macrophages and dendritic cells in obesity-induced insulin resistance |
| Grantee: | Angela Castoldi |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 11/15682-4 - Sepsis and Obesity: study of the relationship between obesity and immune regulation in an experimental model of sepsis |
| Grantee: | Angela Castoldi |
| Support Opportunities: | Scholarships in Brazil - Doctorate |