| Full text | |
| Author(s): |
Paoliello-Paschoalato, Adriana Balbina
[1, 2]
;
Marchi, Larissa Favaro
[1]
;
de Andrade, Micassio Fernandes
[1, 3]
;
Kabeya, Luciana Mariko
[1]
;
Donadi, Eduardo Antonio
[2]
;
Lucisano-Valim, Yara Maria
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | Evidence-based Complementary and Alternative Medicine; 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
Rheumatoid arthritis (RA) is a highly disabling disease that affects all structures of the joint and significantly impacts on morbidity and mortality in RA patients. RA is characterized by persistent inflammation of the synovial membrane lining the joint associated with infiltration of immune cells. Eighty to 90% of the leukocytes infiltrating the synovia are neutrophils. The specific role that neutrophils play in the onset of RA is not clear, but recent studies have evidenced that they have an important participation in joint damage and disease progression through the release of proteolytic enzymes, reactive oxygen species (ROS), cytokines, and neutrophil extracellular traps, in particular during frustrated phagocytosis of immune complexes (ICs). In addition, the local and systemic activation of the complement system contributes to the pathogenesis of RA and other IC-mediated diseases. This review discusses (i) the participation of Fc gamma and complement receptors in mediating the effector functions of neutrophils in RA; (ii) the contribution of the complement system and ROS-dependent and ROS-independent mechanisms to joint damage in RA; and (iii) the use of plant extracts, dietary compounds, and isolated natural compounds in the treatment of RA, focusing on modulation of the effector functions of neutrophils and the complement system activity and/or activation. (AU) | |
| FAPESP's process: | 12/23541-4 - In vitro evaluation of antioxidant and anti-inflammatory derivatives 3-phenylcoumarins in human neutrophils stimulated and in animal models of arthritis. |
| Grantee: | Micássio Fernandes de Andrade |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 07/00840-8 - Study of the mechanism of action of coumarin derivatives on the myeloperoxidase activity: investigation about metabolization of these compounds to phenoxyl free radicals, implications on the oxidative stress and modulation of leukocyte functions |
| Grantee: | Luciana Mariko Kabeya |
| Support Opportunities: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 13/20810-7 - Systematic study of the molecular mechanisms involved in the inhibition of the oxidative metabolism of the stimulated neutrophils by the Baccharis dracunculifolia, 3-phenylcoumarin derivatives and 3,5,7-triidroxiflavonaimplications on the RA therapeutics |
| Grantee: | Yara Maria Lucisano Valim |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/02487-3 - Study of the mechanism of action of coumarin derivatives on the myeloperoxidase activity: investigation about metabolization of these compounds to phenoxyl free radicals, implications on the oxidative stress and modulation of leukocyte functions |
| Grantee: | Yara Maria Lucisano Valim |
| Support Opportunities: | Regular Research Grants |