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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial

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Author(s):
Miranda, Tamires Szeremeske [1] ; Feres, Magda [1] ; Perez-Chaparro, Paula Juliana [1] ; Faveri, Marcelo [1] ; Figueiredo, Luciene Cristina [1] ; Tamashiro, Neila Sumie [1] ; Bastos, Marta Ferreira [1] ; Duarte, Poliana Mendes [1]
Total Authors: 8
Affiliation:
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Clinical Periodontology; v. 41, n. 9, p. 890-899, SEP 2014.
Web of Science Citations: 30
Abstract

Aim: To evaluate the clinical and microbiological effects of the use of metronidazole (MTZ) + amoxicillin (AMX) as adjuncts to scaling and root planing (SRP) for the treatment of chronic periodontitis (ChP) in type 2 diabetic subjects. Material and Methods: Fifty-eight type 2 diabetic subjects (n = 29/group) with generalized ChP were randomly assigned to receive SRP alone or with MTZ {[} 400 mg/thrice a day (TID)]+AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by qPCR for the presence of seven periodontal pathogens. Subjects were monitored at baseline, 3, 6 and 12 months post-therapies. Results: The group receiving SRP+MTZ+AMX presented greater mean probing depth (PD) reduction and clinical attachment gain, a lower number of sites with PD >= 5 mm (primary outcome variable) and a reduced number of subjects with = 9 of these residual pockets than the control group at 1-year post-therapy (p < 0.05). The antibiotic-treated group also presented reduced levels and greater decreases of the three red complex species, Eubacterium nodatum and Prevotella intermedia, compared to the control group at 1 year (p < 0.05). Conclusions: The adjunctive use of MTZ+AMX significantly improved the clinical and microbiological outcomes of SRP in the treatment of type 2 diabetic subjects with ChP. (AU)

FAPESP's process: 11/14872-4 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Tamires Szeremeske de Miranda
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/01072-5 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants