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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of steroid hormones and morphine treatment in the modulation of opioid receptor gene expression in brain structures in the female rat

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Cruz, Wesley Soares [1] ; Pereira, Lucas Assis [1] ; Cezar, Luana Carvalho [1] ; Camarini, Rosana [2] ; Felicio, Luciano Freitas [3] ; Bernardi, Maria Martha [1, 4] ; Teodorov, Elizabeth [4]
Total Authors: 7
[1] Univ Paulista, UNIP, Inst Ciencias Saude, BR-04026002 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med Vet & Zootecnia, BR-05508270 Sao Paulo - Brazil
[4] Univ Fed ABC, Ctr Matemat Computacao & Cognicao, BR-09210971 Santo Andre - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SPRINGERPLUS; v. 4, JUL 16 2015.
Web of Science Citations: 2

This study determined the effects of acute treatment with morphine on the expression of the Oprm1, Oprk1, and Oprd1 genes (which encode mu, kappa, and delta receptors, respectively) in the striatum, hypothalamus, and periaqueductal gray (PAG) in ovariectomized female rats treated with estrogen. Ovariectomized female rats were divided into five equal groups. Two groups received estrogen (50 mu g/kg, 54 h before testing) and saline (ES group) or 3.5 mg/kg morphine (EM group) 2 h before euthanasia. The SS group received saline solution 54 and 2 h before the experiments. The SM group received saline 54 h and 3.5 mg/kg morphine 2 h before the experiments. The W group remained undisturbed. The genes expression were evaluated. Oprm1 and Oprk1 expression were activated, respectively, in the hypothalamus and PAG and in the striatum and PAG by morphine only in estrogen-treated animals. Oprd1 expression in the hypothalamus and PAG was activated by morphine in both estrogen-treated and -nontreated animals. The Oprm1 and Oprk1 gene response to morphine might depend on estrogen, whereas the Oprd1 gene response to morphine might not depend on estrogen, supporting the hypothesis of a functional role for ovarian hormones in opioid receptor-mediated functional adaptations in the female brain. (AU)

FAPESP's process: 13/01610-7 - Subsistence and reproduction: opioidergic modulation of behavioral selection during lactation
Grantee:Luciano Freitas Felicio
Support type: Regular Research Grants