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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs

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Author(s):
Fernandes, Tiago [1] ; Barauna, Valerio G. [2] ; Negrao, Carlos E. [3, 1] ; Phillips, M. Ian [4] ; Oliveira, Edilamar M. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508900 Sao Paulo, SP - Brazil
[2] Fed Univ Esprito Santo, Dept Physiol Sci, Vitoria - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
[4] Keck Grad Inst, Lab Stem Cells, Claremont, CA - USA
Total Affiliations: 4
Document type: Review article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 309, n. 4, p. H543-H552, AUG 15 2015.
Web of Science Citations: 45
Abstract

Left ventricular (LV) hypertrophy is an important physiological compensatory mechanism in response to chronic increase in hemodynamic overload. There are two different forms of LV hypertrophy, one physiological and another pathological. Aerobic exercise induces beneficial physiological LV remodeling. The molecular/cellular mechanisms for this effect are not totally known, and here we review various mechanisms including the role of microRNA (miRNA). Studies in the heart, have identified antihypertrophic miRNA-1, -133, -26, -9, -98, -29, -378, and -145 and prohypertrophic miRNA-143, -103, -130a, -146a, -21, -210, -221, -222, -27a/b, -199a/b, -208, -195, -499, -34a/b/c, -497, -23a, and -15a/b. Four miRNAs are recognized as cardiac-specific: miRNA-1, -133a/b, -208a/b, and -499 and called myomiRs. In our studies we have shown that miRNAs respond to swimming aerobic exercise by 1) decreasing cardiac fibrosis through miRNA-29 increasing and inhibiting collagen, 2) increasing angiogenesis through miRNA-126 by inhibiting negative regulators of the VEGF pathway, and 3) modulating the renin-angiotensin system through the miRNAs-27a/b and -143. Exercise training also increases cardiomyocyte growth and survival by swimming-regulated miRNA-1, -21, -27a/b, -29a/c, -30e, -99b, -100, -124, -126, -133a/b, -143, -144, -145, -208a, and -222 and running-regulated miRNA-1, -26, -27a, -133, -143, -150, and -222, which influence genes associated with the heart remodeling and angiogenesis. We conclude that there is a potential role of these miRNAs in promoting cardioprotective effects on physiological growth. (AU)

FAPESP's process: 14/50673-4 - A new therapeutic approach to arterial repair and regeneration by exercise training and microRNAs targeted to vasorin
Grantee:Edilamar Menezes de Oliveira
Support type: Regular Research Grants
FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants